Esketamine
- Generic Name
- Esketamine
- Brand Names
- Spravato
- Drug Type
- Small Molecule
- Chemical Formula
- C13H16ClNO
- CAS Number
- 33643-46-8
- Unique Ingredient Identifier
- 50LFG02TXD
- Background
Major depressive disorder (MDD) is a significant cause of disability worldwide and the most common illness preceding suicide. On March 5, 2019, the nasal spray drug, esketamine, also known as Spravato (by Janssen Pharmaceuticals), was approved by the FDA for treatment-resistant major depression.
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- Indication
Esketamine is indicated in combination with an oral antidepressant for the treatment of treatment-resistant depression in adults. It is also indicated for the treatment of depressive symptoms in adults with major depressive disorder experiencing acute suicidal ideation or behaviour.
- Associated Conditions
- Major Depressive Disorder (MDD), Major depressive disorder, recurrent episode, Pain
- Associated Therapies
- Intubation
A Study to Assess the Pharmacokinetics, Safety, and Tolerability of Intranasally Administered Esketamine in Healthy Participants
- First Posted Date
- 2013-01-31
- Last Posted Date
- 2013-08-09
- Lead Sponsor
- Janssen Research & Development, LLC
- Target Recruit Count
- 58
- Registration Number
- NCT01780259
A Study of the Efficacy of Intravenous Esketamine in Adult Patients With Treatment-Resistant Depression
- First Posted Date
- 2012-07-13
- Last Posted Date
- 2020-06-02
- Lead Sponsor
- Janssen Research & Development, LLC
- Target Recruit Count
- 30
- Registration Number
- NCT01640080
Racemic Ketamine Versus S-ketamine With Arterial Spin Labeling (ASL)-MRI in Healthy Volunteers
- Conditions
- Interventions
- First Posted Date
- 2012-01-10
- Last Posted Date
- 2012-02-22
- Lead Sponsor
- Lund University
- Target Recruit Count
- 14
- Registration Number
- NCT01506921
- Locations
- 🇸🇪
Deprtment of radiology, SUS, Malmö, Malmö, Sweden
The Preemptive Analgetic Potency of Low Dose S-Ketamine
- First Posted Date
- 2009-12-01
- Last Posted Date
- 2012-10-02
- Lead Sponsor
- Medical University of Graz
- Target Recruit Count
- 60
- Registration Number
- NCT01022840
- Locations
- 🇦🇹
Medical University of Graz, Graz, Austria
🇦🇹Medical University Graz, Graz, Styria, Austria
Anesthetics and Auditory, Visceral, and Heat Evoked Potentials
- Conditions
- Interventions
- First Posted Date
- 2007-09-26
- Last Posted Date
- 2007-09-26
- Lead Sponsor
- Technical University of Munich
- Target Recruit Count
- 60
- Registration Number
- NCT00534586
- Locations
- 🇩🇪
Technische Universität München, Klinikum rechts der Isar, Department of Anesthesiology, Munich, Bavaria, Germany
Optimal Multimodal Analgesia in Laparoscopic Cholecystectomy
- Conditions
- First Posted Date
- 2005-09-21
- Last Posted Date
- 2005-09-21
- Lead Sponsor
- Hvidovre University Hospital
- Target Recruit Count
- 60
- Registration Number
- NCT00209885
- Locations
- 🇩🇰
Dept of Anaesthesia, Hvidovre Hospital, Copenhagen, Hvidovre, Denmark
Optimal Multimodal Analgesia in Abdominal Hysterectomy
- Conditions
- First Posted Date
- 2005-09-21
- Last Posted Date
- 2007-11-07
- Lead Sponsor
- Hvidovre University Hospital
- Target Recruit Count
- 60
- Registration Number
- NCT00209872
- Locations
- 🇩🇰
Dept. of Anaesthesia, Hvidovre Hospital, Copenhagen, Hvidovre, Denmark
Sensory Examination and Pharmacological Modulation of Oral Hyperexcitability in Patients With Atypical Odontalgia and Matched Healthy Controls
- Conditions
- First Posted Date
- 2005-06-21
- Last Posted Date
- 2006-06-20
- Lead Sponsor
- University of Aarhus
- Target Recruit Count
- 20
- Registration Number
- NCT00115102
- Locations
- 🇩🇰
Danish Pain Research Center, Aarhus, Denmark
Drug Development Updates
Stay informed with timely notifications on clinical trials, regulatory changes, and research advancements related to this medication.