Esketamine
- Generic Name
- Esketamine
- Brand Names
- Spravato
- Drug Type
- Small Molecule
- Chemical Formula
- C13H16ClNO
- CAS Number
- 33643-46-8
- Unique Ingredient Identifier
- 50LFG02TXD
- Background
Major depressive disorder (MDD) is a significant cause of disability worldwide and the most common illness preceding suicide. On March 5, 2019, the nasal spray drug, esketamine, also known as Spravato (by Janssen Pharmaceuticals), was approved by the FDA for treatment-resistant major depression.
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- Indication
Esketamine is indicated in combination with an oral antidepressant for the treatment of treatment-resistant depression in adults. It is also indicated for the treatment of depressive symptoms in adults with major depressive disorder experiencing acute suicidal ideation or behaviour.
- Associated Conditions
- Major Depressive Disorder (MDD), Major depressive disorder, recurrent episode, Pain
- Associated Therapies
- Intubation
Mini-dose Esketamine-dexmedetomidine Supplemented Analgesia and Long-term Outcomes
- Conditions
- Interventions
- First Posted Date
- 2023-02-08
- Last Posted Date
- 2023-02-09
- Lead Sponsor
- Peking University First Hospital
- Target Recruit Count
- 199
- Registration Number
- NCT05718544
- Locations
- 🇨🇳
Peking University First Hospital, Beijing, Beijing, China
Effect of Subanesthetic Dose of Esketamine on Sleep Quality and Recovery of Gastrointestinal Function in Patients Undergoing General Anesthesia Laparoscopic Uterine Surgery in the Early Postoperative Period
- Conditions
- Interventions
- First Posted Date
- 2023-02-08
- Last Posted Date
- 2024-05-21
- Lead Sponsor
- Zhuan Zhang
- Target Recruit Count
- 138
- Registration Number
- NCT05715671
- Locations
- 🇨🇳
the Affiliated Hospital of Yangzhou University, Yangzhou, Jiangsu, China
Effect of Low-dose Esketamine on Maternal Depression at 3 Years After Childbirth
- Conditions
- Interventions
- First Posted Date
- 2023-01-26
- Last Posted Date
- 2024-12-05
- Lead Sponsor
- Peking University First Hospital
- Target Recruit Count
- 364
- Registration Number
- NCT05698394
- Locations
- 🇨🇳
Women's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China
🇨🇳Hunan Provincial Maternal and Child Health Care Hospital, Changsha, Hunan, China
🇨🇳Women's Hospital of Nanjing Medical University, Nanjing, Jiangsu, China
Remiazolam Combined With Esketamine in Painless Bidirectional Endoscopy in Children
- Conditions
- Interventions
- First Posted Date
- 2023-01-17
- Last Posted Date
- 2023-08-21
- Lead Sponsor
- Tongji Hospital
- Target Recruit Count
- 106
- Registration Number
- NCT05686863
- Locations
- 🇨🇳
Tongji Hospital, Wuhan, Hubei, China
Effects of Esketamine on Acute Abdominal Pain After TACE in Patients With Hepatocellular Carcinoma
- Conditions
- Interventions
- First Posted Date
- 2023-01-04
- Last Posted Date
- 2023-03-29
- Target Recruit Count
- 60
- Registration Number
- NCT05670561
- Locations
- 🇨🇳
The Second Affiliated Hospital, Chongqing Medical University, Chongqing, Chongqing, China
Remimazolam Versus Propofol for Painless Abortion
- Conditions
- Interventions
- First Posted Date
- 2022-12-02
- Last Posted Date
- 2022-12-02
- Target Recruit Count
- 100
- Registration Number
- NCT05635955
- Locations
- 🇨🇳
Maternal and Child Health Hospital of Hubei Province, Wuhan, Hubei, China
KetaMoHydBup: Pharmacokinetic Interaction of S-ketamine, Morphine, Hydromorphone and Buprenorphine
- Conditions
- Interventions
- First Posted Date
- 2022-10-07
- Last Posted Date
- 2022-10-07
- Lead Sponsor
- Elina Brinck
- Target Recruit Count
- 12
- Registration Number
- NCT05571176
VA Aripiprazole vs Esketamine for Treatment Resistant Depression
- First Posted Date
- 2022-09-26
- Last Posted Date
- 2024-01-05
- Lead Sponsor
- VA Office of Research and Development
- Registration Number
- NCT05554627
- Locations
- 🇺🇸
Central Arkansas VHS John L. McClellan Memorial Veterans Hospital, Little Rock, AR, Little Rock, Arkansas, United States
🇺🇸New Mexico VA Health Care System, Albuquerque, NM, Albuquerque, New Mexico, United States
🇺🇸Edward Hines Jr. VA Hospital, Hines, IL, Hines, Illinois, United States
Comparison of Analgesic and Sedative Effects of Esmketamine and Remifentanil Combined With Propofol Respectively in Septic Shock Patients With Invasive Mechanical Ventilation
- Conditions
- Interventions
- First Posted Date
- 2022-09-23
- Last Posted Date
- 2022-09-23
- Lead Sponsor
- The First Hospital of Jilin University
- Target Recruit Count
- 120
- Registration Number
- NCT05551910
The Effects of Intraoperative Esketamine on Postoperative Pain and Mood in Patients With Inflammatory Bowel Disease
- Conditions
- Interventions
- First Posted Date
- 2022-08-18
- Last Posted Date
- 2023-04-04
- Lead Sponsor
- Jinling Hospital, China
- Target Recruit Count
- 120
- Registration Number
- NCT05506787
- Locations
- 🇨🇳
Anesthesiology Department, Jinling Hospital Affiliated to Nanjing University, Nanjing, Jiangsu, China
Drug Development Updates
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