Esketamine
- Generic Name
- Esketamine
- Brand Names
- Spravato
- Drug Type
- Small Molecule
- Chemical Formula
- C13H16ClNO
- CAS Number
- 33643-46-8
- Unique Ingredient Identifier
- 50LFG02TXD
- Background
Major depressive disorder (MDD) is a significant cause of disability worldwide and the most common illness preceding suicide. On March 5, 2019, the nasal spray drug, esketamine, also known as Spravato (by Janssen Pharmaceuticals), was approved by the FDA for treatment-resistant major depression.
...
- Indication
Esketamine is indicated in combination with an oral antidepressant for the treatment of treatment-resistant depression in adults. It is also indicated for the treatment of depressive symptoms in adults with major depressive disorder experiencing acute suicidal ideation or behaviour.
- Associated Conditions
- Major Depressive Disorder (MDD), Major depressive disorder, recurrent episode, Pain
- Associated Therapies
- Intubation
An Exploratory Study of Esketamine in Patients After Thoracoscopic Surgery
- First Posted Date
- 2022-07-14
- Last Posted Date
- 2023-08-16
- Target Recruit Count
- 80
- Registration Number
- NCT05458453
- Locations
- 🇨🇳
Department of Anesthesiology, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, Chongqing, China
🇨🇳The Second Affiliated Hospital, Chongqing Medical University, Chongqing, Chongqing, China
Long-Term Maintenance With Ketamine and Esketamine for Reduction of Suicide in High-Risk Patients With Depression
- First Posted Date
- 2022-07-08
- Last Posted Date
- 2023-01-25
- Lead Sponsor
- Massachusetts General Hospital
- Target Recruit Count
- 100
- Registration Number
- NCT05450432
- Locations
- 🇺🇸
Massachusetts General Hospital, Boston, Massachusetts, United States
Effect of Esketamine on Abdominal Pain During TACE-HAIC in Patients With Hepatocellular Carcinoma
- First Posted Date
- 2022-06-13
- Last Posted Date
- 2023-02-24
- Target Recruit Count
- 70
- Registration Number
- NCT05416073
- Locations
- 🇨🇳
The Second Affiliated Hospital, Chongqing Medical University, Chongqing, Chongqing, China
Effect of S-ketamine in Cesarean Section Combined Anesthesia
- First Posted Date
- 2022-06-10
- Last Posted Date
- 2023-02-24
- Target Recruit Count
- 120
- Registration Number
- NCT05414006
- Locations
- 🇨🇳
Department of Anesthesiology, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, Chongqing, China
Effects of Thoracic Paravertebral Block Combined With S-ketamine on Postoperative Pain and Cognitive Function After Thoracoscopic Surgery
- Conditions
- Interventions
- First Posted Date
- 2022-04-22
- Last Posted Date
- 2022-05-06
- Lead Sponsor
- The First Hospital of Qinhuangdao
- Target Recruit Count
- 110
- Registration Number
- NCT05341375
- Locations
- 🇨🇳
The First hosptial of Qinhuangdao, Qinhuangdao, China
Comparison of the Sedation Effect of Esketamine and Sevoflurane for Pediatric Ophthalmological Procedure
- First Posted Date
- 2022-04-11
- Last Posted Date
- 2024-03-26
- Lead Sponsor
- Eye & ENT Hospital of Fudan University
- Target Recruit Count
- 116
- Registration Number
- NCT05321160
- Locations
- 🇨🇳
Anesthesiology Department of Affiliated Eye and ENT Hospital, Fudan University, Shanghai, Shanghai, China
Effects of S-ketamine and Continuous Iliac Fascia Space Block on Perioperative Neurological Cognitive Impairment and Postoperative Rehabilitation in Elderly Patients With Hip Fracture
- Conditions
- Interventions
- First Posted Date
- 2022-03-31
- Last Posted Date
- 2022-03-31
- Lead Sponsor
- Yangzhou University
- Target Recruit Count
- 108
- Registration Number
- NCT05304559
- Locations
- 🇨🇳
Affiliated Hospital of Yangzhou University, Yangzhou, China
The Effect of S-ketamine Combined With Sufentanil for Postoperative Analgesia in Patients Following Cesarean Section
- Conditions
- Interventions
- First Posted Date
- 2022-03-29
- Last Posted Date
- 2023-02-28
- Lead Sponsor
- Ling Dong
- Target Recruit Count
- 216
- Registration Number
- NCT05299866
- Locations
- 🇨🇳
Qianfoshan Hospital, The First Hospital affiliated of Shandong First Medical University, Jinan, Shandong, China
Analgesic Effect of Intraoperative Intravenous S-Ketamine During Total Knee Arthroplasty Surgery
- Conditions
- Interventions
- First Posted Date
- 2022-03-21
- Last Posted Date
- 2023-02-28
- Lead Sponsor
- Ling Dong
- Target Recruit Count
- 144
- Registration Number
- NCT05289050
- Locations
- 🇨🇳
Qianfoshan Hospital, The First Hospital affiliated of Shandong First Medical University, Jinan, Shandong, China
A Study to Assess Feasibility of Using Clinician-directed and Digital Application Supported Cognitive Behavior Therapy (CBT) in Conjunction With Esketamine in Participants With Treatment-resistant Depression
- Conditions
- Interventions
- First Posted Date
- 2022-03-07
- Last Posted Date
- 2022-09-22
- Lead Sponsor
- Janssen Research & Development, LLC
- Registration Number
- NCT05268497
- Locations
- 🇺🇸
University of Chicago, Chicago, Illinois, United States
🇺🇸Sheppard Pratt Health System, Baltimore, Maryland, United States
🇺🇸Rush University Medical Center, Chicago, Illinois, United States
Drug Development Updates
Stay informed with timely notifications on clinical trials, regulatory changes, and research advancements related to this medication.