Fentanyl
- Generic Name
- Fentanyl
- Brand Names
- Abstral, Actiq, Duragesic, Effentora, Fentora, Instanyl, Lazanda, Sublimaze, Subsys, PecFent
- Drug Type
- Small Molecule
- Chemical Formula
- C22H28N2O
- CAS Number
- 437-38-7
- Unique Ingredient Identifier
- UF599785JZ
- Background
Fentanyl, a potent opioid agonist, was developed in the 1950s to fill a need for strong and rapid analgesia. Because of these characteristics, fentanyl is commonly used to treat chronic cancer pain or in anesthesia. Fentanyl is related to other opioids like morphine and oxycodone.
Fentanyl's high potency has also made it a common adulterant in illicit drugs, especially heroin. In 2017, 47600 overdose deaths in the United States involved some opioid (over 2/3 of all overdose deaths). Opioid overdoses kill an average of 11 Canadians daily.
Fentanyl was FDA approved in 1968.
- Indication
Fentanyl intravenous or intramuscular injections are indicated for short term analgesia during induction, maintenance, and recovery from general or regional anesthesia. These injections are also used with a neuroleptic for premedication, induction, and as an adjunct to maintenance of anesthesia. Finally, fentanyl intravenous or intramuscular injections are used with oxygen for anesthesia in high risk patients.
Fentanyl sublingual tablets, transmucosal lozenges, buccal tablets, sublingual sprays, transdermal systems, and nasal sprays are indicated for the management of breakthrough pain in opioid tolerant cancer patients who require around the clock pain management.
- Associated Conditions
- Cancer Related Pain (Breakthrough Pain), Severe, Chronic Pain
- Associated Therapies
- Anesthetic premedication therapy, Anesthetics Agent, General Anesthesia, Induction of anesthesia therapy, Maintenance of anesthesia therapy, Regional Anesthesia therapy
Rapip Study: Clinical Trial on Remifentanyl for Analgesia and Sedation of Ventilated Neonates and Infants
- First Posted Date
- 2007-01-08
- Last Posted Date
- 2010-06-25
- Lead Sponsor
- University of Cologne
- Target Recruit Count
- 24
- Registration Number
- NCT00419601
- Locations
- 🇩🇪
Clinic for Paediatrics, University of Cologne Kerpener Str. 62, Cologne, Germany
Intranasal Fentanyl Versus Placebo for Catheterization During a Voiding Cystourethrogram in Children
- First Posted Date
- 2006-11-30
- Last Posted Date
- 2010-12-13
- Lead Sponsor
- The Hospital for Sick Children
- Target Recruit Count
- 64
- Registration Number
- NCT00405444
- Locations
- 🇨🇦
The Hospital for Sick Children, Toronto, Ontario, Canada
Acute Neurological ICU Sedation Trial (ANIST)
- Conditions
- Sedation
- Interventions
- First Posted Date
- 2006-10-20
- Last Posted Date
- 2019-05-16
- Lead Sponsor
- Johns Hopkins University
- Target Recruit Count
- 35
- Registration Number
- NCT00390871
- Locations
- 🇺🇸
Johns Hopkins University, Baltimore, Maryland, United States
Efficacy and Safety of Intranasal Fentanyl in the Treatment of Breakthrough Pain (FT-018-IM)
- Conditions
- Cancer
- First Posted Date
- 2006-08-10
- Last Posted Date
- 2012-05-07
- Lead Sponsor
- Nycomed
- Target Recruit Count
- 100
- Registration Number
- NCT00362583
- Locations
- 🇩🇰
Nycomed, Roskilde, Denmark
Intranasal Fentanyl for the Treatment of Breakthrough Pain in Cancer Patients (FT-017-IM)
- Conditions
- CancerPain
- First Posted Date
- 2006-06-28
- Last Posted Date
- 2012-05-07
- Lead Sponsor
- Nycomed
- Target Recruit Count
- 150
- Registration Number
- NCT00345735
- Locations
- 🇩🇰
Nycomed, Roskilde, Denmark
Effect of Dexmedetomidine Upon Sleep Postoperatively
- Conditions
- Sleep
- First Posted Date
- 2006-06-06
- Last Posted Date
- 2014-07-14
- Lead Sponsor
- Duke University
- Registration Number
- NCT00333632
- Locations
- 🇺🇸
Duke University Medical Center, Durham, North Carolina, United States
Effects of Additional Fentanyl to Epidural Bupivacaine for Post-Thoracotomy Pain in Neonates
- First Posted Date
- 2006-02-03
- Last Posted Date
- 2009-09-16
- Lead Sponsor
- Children's Hospital of Philadelphia
- Target Recruit Count
- 32
- Registration Number
- NCT00286143
- Locations
- 🇺🇸
The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States
Postoperative Pain After Orthopedic Surgery: Does it Help to Give Fentanyl Before Start of Remifentanil Based Anesthesia?
- Conditions
- Pain, Postoperative
- First Posted Date
- 2005-10-18
- Last Posted Date
- 2011-07-06
- Lead Sponsor
- Ullevaal University Hospital
- Target Recruit Count
- 100
- Registration Number
- NCT00241332
- Locations
- 🇳🇴
Ullevaal University Hospital, Oslo, Norway
A Study of the Effect on Pain Control of Treatment With Fentanyl, Administered Through the Skin, Compared With Placebo in Patients With Osteoarthritis
- Conditions
- OsteoarthritisArthritis
- First Posted Date
- 2005-10-12
- Last Posted Date
- 2011-05-17
- Lead Sponsor
- Janssen Pharmaceutica N.V., Belgium
- Target Recruit Count
- 418
- Registration Number
- NCT00236366
Evaluation of the Efficacy and Safety of Fentanyl Delivered by Adhesive Skin Patch in Out-Patients With Chronic Cancer Pain
- Conditions
- Pain
- First Posted Date
- 2005-10-12
- Last Posted Date
- 2011-05-17
- Lead Sponsor
- Janssen Cilag S.A.S.
- Target Recruit Count
- 34
- Registration Number
- NCT00236327
Drug Development Updates
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