Trametinib is an orally bioavailable mitogen-activated extracellular signal-regulated kinase 1 (MEK1) and MEK2 inhibitor. It was first approved by the FDA in May 2013 for the treatment of melanoma. It was later approved by Health Canada on July 18, 2013 and by the European Commission on June 30, 2014. Trametinib is currently approved to treat a variety of c...
Trametinib is indicated as monotherapy for the treatment of BRAF-inhibitor treatment-naïve patients with unresectable or metastatic melanoma with BRAF V600E or V600K mutations.
It is used in combination with dabrafenib for the:
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Siteman Cancer Center, Saint Louis, Missouri, United States
Massachusetts General Hospital, Boston, Massachusetts, United States
Rutgers Cancer Institute, New Brunswick, New Jersey, United States
Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia
Saint-Petersburg State University (SPSU) N.I.Pirogov Clinic of High Medical Technologies, Saint Petersburg, Russian Federation
Cleveland Clinic Taussig Cancer Institute, Cleveland, Ohio, United States
M D Anderson Cancer Center, Houston, Texas, United States
Stanford School of Medicine, Stanford, California, United States
Novartis Investigative Site, Wuhan, China
National Institutes of Health Clinical Center, Bethesda, Maryland, United States
Memorial Sloan Kettering Bergen (Limited Protocol Activities), Montvale, New Jersey, United States
Memorial Sloan Kettering Basking Ridge (Limited Protocol Activities), Basking Ridge, New Jersey, United States
Memorial Sloan Kettering Monmouth (Limited protocol activities), Middletown, New Jersey, United States
M D Anderson Cancer Center, Houston, Texas, United States
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