Norepinephrine
- Generic Name
- Norepinephrine
- Brand Names
- Levophed
- Drug Type
- Small Molecule
- Chemical Formula
- C8H11NO3
- CAS Number
- 51-41-2
- Unique Ingredient Identifier
- X4W3ENH1CV
- Background
Precursor of epinephrine that is secreted by the adrenal medulla and is a widespread central and autonomic neurotransmitter. Norepinephrine is the principal transmitter of most postganglionic sympathetic fibers and of the diffuse projection system in the brain arising from the locus ceruleus. It is also found in plants and is used pharmacologically as a sympathomimetic.
- Indication
Mainly used to treat patients in vasodilatory shock states such as septic shock and neurogenic shock and has shown a survival benefit over dopamine. Also used as a vasopressor medication for patients with critical hypotension.
- Associated Conditions
- Cardiac Arrest, Severe hypotension, Shock, Acute, severe Hypotension
Comparative Efficacity of Ephedrine Versus Norepinephrine to Correct Anesthesia Induction Related Hypotension
- First Posted Date
- 2022-08-11
- Last Posted Date
- 2022-09-16
- Lead Sponsor
- Brugmann University Hospital
- Target Recruit Count
- 60
- Registration Number
- NCT05497700
- Locations
- 🇧🇪
CHU Brugmann, Brussels, Belgium
The Effect of Epinephrine, Norepinephrine and Phenylephrine on Intraoperative Hemodynamic Performance
- Conditions
- Cardiac Output, LowCardiac Output, HighPerfusion; Complications
- Interventions
- First Posted Date
- 2022-08-09
- Last Posted Date
- 2022-10-19
- Lead Sponsor
- Medical University of Vienna
- Target Recruit Count
- 225
- Registration Number
- NCT05492968
- Locations
- 🇦🇹
Medical University of Vienna, Vienna, Austria
Lung Ultrasound-guided Hemodynamic Optimization
- Conditions
- Lung UltrasoundGoal Directed TherapyNon-cardiac Surgery
- Interventions
- Procedure: pulmonary ultrasound after vascular filling
- First Posted Date
- 2022-08-01
- Last Posted Date
- 2022-08-26
- Lead Sponsor
- Centre Hospitalier Universitaire, Amiens
- Target Recruit Count
- 350
- Registration Number
- NCT05481723
- Locations
- 🇫🇷
CHU Amiens, Amiens, France
Effects of Vasopressors on Cerebral Hemodynamics in Patients With Carotid Endarterectomy (MRI Part)
- Conditions
- Carotid Endarterectomy
- Interventions
- First Posted Date
- 2022-06-10
- Last Posted Date
- 2023-08-24
- Lead Sponsor
- Beijing Tiantan Hospital
- Target Recruit Count
- 60
- Registration Number
- NCT05414877
Comparison Between Three Norepinephrine Bolus Doses for Management of Post-spinal Hypotension During Ceaserian Section for Patients With Preeclampsia
- Conditions
- Anesthesia; Adverse EffectCesarean Section Complications
- Interventions
- First Posted Date
- 2022-05-10
- Last Posted Date
- 2022-08-18
- Lead Sponsor
- Kasr El Aini Hospital
- Target Recruit Count
- 60
- Registration Number
- NCT05368415
- Locations
- 🇪🇬
Cairo university, Kasr Alainy hospital, Cairo, Egypt
Using Vasopressor Medication to Support Blood Pressure During Intubation Procedure
- Conditions
- Hypotension and ShockAnesthesia Intubation ComplicationRespiratory FailureIntubation ComplicationHypotension on Induction
- Interventions
- First Posted Date
- 2022-05-02
- Last Posted Date
- 2024-07-15
- Lead Sponsor
- Wright State University
- Target Recruit Count
- 42
- Registration Number
- NCT05355974
- Locations
- 🇺🇸
Miami Valley Hospital Premier Health, Dayton, Ohio, United States
Dopamine vs. Norepinephrine for Hypotension in Very Preterm Infants With Late-onset Sepsis
- Conditions
- Late-Onset Neonatal SepsisNeonatal HypotensionExtreme Prematurity
- Interventions
- First Posted Date
- 2022-04-26
- Last Posted Date
- 2024-11-08
- Lead Sponsor
- Mount Sinai Hospital, Canada
- Target Recruit Count
- 550
- Registration Number
- NCT05347238
- Locations
- 🇺🇸
Banner-University Medical Center Phoenix, Phoenix, Arizona, United States
🇺🇸Dayton Children's Hospital, Dayton, Ohio, United States
🇺🇸El Paso Children's Hospital, El Paso, Texas, United States
Therapeutic Study Evaluating the Efficacy of Noradrenaline in the Prevention of Hypotension Related to Intubation for Cardiac or Thoracic Surgery
- First Posted Date
- 2022-04-20
- Last Posted Date
- 2024-03-07
- Lead Sponsor
- Nantes University Hospital
- Target Recruit Count
- 211
- Registration Number
- NCT05335954
- Locations
- 🇫🇷
Chu de Nantes, Nantes, France
Effect of a FLUid Bolus or a Low Dose VAsopressor Infusion on Cardiovascular Collapse Among Critically Ill Adults Undergoing Tracheal Intubation.
- Conditions
- Critically Ill Adults in the ICU, Requiring Endotracheal Intubation
- Interventions
- First Posted Date
- 2022-04-08
- Last Posted Date
- 2025-01-17
- Lead Sponsor
- Tata Memorial Centre
- Target Recruit Count
- 200
- Registration Number
- NCT05318066
- Locations
- 🇮🇳
Tata Memorial Hospital, Mumbai, Maharashtra, India
Two Norepinephrine Rescue Bolus Doses for Management of Severe Post-spinal Hypotension During Elective Cesarean Delivery
- Conditions
- NorepinephrineCesarean DeliveryPostspinal Hypotension
- Interventions
- First Posted Date
- 2022-03-22
- Last Posted Date
- 2023-06-18
- Lead Sponsor
- Kasr El Aini Hospital
- Target Recruit Count
- 158
- Registration Number
- NCT05290740
- Locations
- 🇪🇬
Kasr Alaini Hospital, Cairo, Egypt
Drug Development Updates
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