Fospropofol
- Generic Name
- Fospropofol
- Drug Type
- Small Molecule
- Chemical Formula
- C13H21O5P
- CAS Number
- 258516-89-1
- Unique Ingredient Identifier
- LZ257RZP7K
- Background
Fospropofol is a water soluble prodrug and is converted to propofol in the liver. Fospropofol is a short acting hypnotic/sedative/anesthetic agent. Unlike propofol, does not cause injection-site pain as it is unable to activate TRPA1. FDA approved in December 2008.
Fospropofol is a Schedule IV controlled substance in the United States under the Controlled Substances Act.
- Indication
For monitored anaesthesia care sedation in patients undergoing diagnostic procedures like bronchoscopy and colonscopy or minor surgical procedures like arthroscopy and bunionectomy.
- Associated Therapies
- Monitored anesthesia care sedation
A PK/PD Study of Fospropofol Disodium Compared With Propofol Injectable Emulsion
- First Posted Date
- 2010-12-15
- Last Posted Date
- 2017-01-27
- Lead Sponsor
- Eisai Inc.
- Target Recruit Count
- 36
- Registration Number
- NCT01260142
- Locations
- 🇺🇸
Duke University Medical Center, Durham, North Carolina, United States
A Dose-ranging Study to Evaluate the Safety and Efficacy of LUSEDRA (Fospropofol Disodium) as an Intravenous Sedative for Diagnostic or Therapeutic Colonoscopy in Adult Special Populations
- Conditions
- Sedation
- Interventions
- First Posted Date
- 2010-05-20
- Last Posted Date
- 2013-02-08
- Lead Sponsor
- Eisai Inc.
- Target Recruit Count
- 153
- Registration Number
- NCT01127438
- Locations
- 🇺🇸
Washington Hospital Center, Washington, District of Columbia, United States
🇺🇸Miami Research Associates, South Miami, Florida, United States
🇺🇸Research Associates of New York, LLP, New York, New York, United States
Comparison of AQUAVAN® Injection to DISOPRIVAN® Injectable Emulsion for Anesthesia During Coronary Artery Surgery
- Conditions
- Ischemic Coronary Artery DiseaseCoronary Artery Bypass Surgery
- Interventions
- First Posted Date
- 2005-09-21
- Last Posted Date
- 2010-06-11
- Lead Sponsor
- Eisai Inc.
- Target Recruit Count
- 16
- Registration Number
- NCT00209521
Drug Development Updates
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