Fospropofol
- Generic Name
- Fospropofol
- Drug Type
- Small Molecule
- Chemical Formula
- C13H21O5P
- CAS Number
- 258516-89-1
- Unique Ingredient Identifier
- LZ257RZP7K
- Background
Fospropofol is a water soluble prodrug and is converted to propofol in the liver. Fospropofol is a short acting hypnotic/sedative/anesthetic agent. Unlike propofol, does not cause injection-site pain as it is unable to activate TRPA1. FDA approved in December 2008.
Fospropofol is a Schedule IV controlled substance in the United States under the Controlled Substances Act.
- Indication
For monitored anaesthesia care sedation in patients undergoing diagnostic procedures like bronchoscopy and colonscopy or minor surgical procedures like arthroscopy and bunionectomy.
- Associated Therapies
- Monitored anesthesia care sedation
Clinical Study of Fospropofol Disodium for Injection in the Painless Endoscopic Diagnosis and Treatment
- Conditions
- Efficacy and Safety
- Interventions
- First Posted Date
- 2024-12-13
- Last Posted Date
- 2024-12-13
- Lead Sponsor
- Affiliated Hospital of Nantong University
- Target Recruit Count
- 426
- Registration Number
- NCT06732427
- Locations
- 🇨🇳
Yongtao Gao, Nantong, Jiangsu, China
Efficacy and Safety of Fospropofol in Adult Laparoscopic Surgery: A Clinical Trial
- First Posted Date
- 2024-08-27
- Last Posted Date
- 2025-04-16
- Lead Sponsor
- Hui Xu
- Target Recruit Count
- 373
- Registration Number
- NCT06573489
- Locations
- 🇨🇳
Tongji Hospital, Wuhan, Hubei, China
ED90 of Fospropofol Disodium in Induction and Maintenance of Anesthesia
- First Posted Date
- 2024-04-03
- Last Posted Date
- 2024-07-03
- Lead Sponsor
- Tongji Hospital
- Target Recruit Count
- 330
- Registration Number
- NCT06344325
- Locations
- 🇨🇳
Tongji hospital, Wuhan, Hubei, China
Safety and Efficacy of Fospropofol vs Propofol During Invasive Mechanical Ventilation.
- Conditions
- Invasive Mechanical Ventilation
- Interventions
- First Posted Date
- 2024-02-15
- Last Posted Date
- 2024-02-15
- Lead Sponsor
- Henan Provincial People's Hospital
- Target Recruit Count
- 200
- Registration Number
- NCT06261996
Efficacy and Safety of Fospropofol for Same-day Bidirectional Endoscopy in Elderly Patients
- Conditions
- Elderly Patients
- Interventions
- First Posted Date
- 2024-02-09
- Last Posted Date
- 2024-02-09
- Lead Sponsor
- Shanghai 6th People's Hospital
- Target Recruit Count
- 256
- Registration Number
- NCT06251999
Efficacy and Safety of Fospropofol Disodium Versus Propofol for Deep Sedation in Critically Ill Patients
- Conditions
- Critical Illness
- Interventions
- First Posted Date
- 2023-05-23
- Last Posted Date
- 2023-07-05
- Lead Sponsor
- Xiaobo Yang, MD
- Target Recruit Count
- 60
- Registration Number
- NCT05870514
- Locations
- 🇨🇳
Wuhan Union Hospital, Wuhan, Hubei, China
Efficacy and Safety of Fospropofol Disodium Versus Propofol for Sedation in Mechanically Ventilated ICU Patients
- Conditions
- Critical Illness
- Interventions
- First Posted Date
- 2022-08-08
- Last Posted Date
- 2023-09-21
- Lead Sponsor
- Xiaobo Yang, MD
- Target Recruit Count
- 60
- Registration Number
- NCT05491278
- Locations
- 🇨🇳
Department of Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
Preventing Propofol Injection Pain: Prospective Randomized Trial Comparing Propofol Versus Fospropofol
- Conditions
- Complication of InjectionPain
- Interventions
- Drug: Propofol/Lidocaine
- First Posted Date
- 2011-07-25
- Last Posted Date
- 2017-12-29
- Lead Sponsor
- NYU Langone Health
- Target Recruit Count
- 116
- Registration Number
- NCT01401049
- Locations
- 🇺🇸
NYU Langone Medical Center, New York, New York, United States
Evaluate The Effectiveness Of Fospropofol (Lusedra®) For Induction Of Anesthesia
- Conditions
- Interstitial Cystitis
- Interventions
- First Posted Date
- 2011-06-22
- Last Posted Date
- 2012-10-03
- Lead Sponsor
- Grace Shih, MD
- Registration Number
- NCT01378754
Fospropofol for Sedation During Elective Awake Intubation
- First Posted Date
- 2011-02-03
- Last Posted Date
- 2017-04-18
- Lead Sponsor
- The Cleveland Clinic
- Registration Number
- NCT01289483
- Locations
- 🇺🇸
Cleveland Clinic, Cleveland, Ohio, United States
Drug Development Updates
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