Spironolactone
- Generic Name
- Spironolactone
- Brand Names
- Aldactazide, Aldactone, Carospir, Qaialdo
- Drug Type
- Small Molecule
- Chemical Formula
- C24H32O4S
- CAS Number
- 52-01-7
- Unique Ingredient Identifier
- 27O7W4T232
- Background
Spironolactone is a potassium-sparing diuretic. It binds to mineralocorticoid receptors and functions as aldosterone antagonists. It promotes sodium and water excretion and potassium retention. Spironolactone was originally developed purely for this ability before other pharmacodynamic properties of the drug were discovered. It is indicated to treat several conditions, including heart failure, edema, hyperaldosteronism, and hypertension. Off-label uses of spironolactone include hirsutism, female pattern hair loss, and adult acne vulgaris.
Spironolactone was developed in 1957, marketed in 1959, and approved by the FDA on January 21, 1960.
- Indication
Spironolactone is indicated for the treatment of the following conditions:
As spironolactone has antiandrogenic activity, its off-label uses include the treatment of hirsutism, female pattern hair loss, and adult acne vulgaris.
- Associated Conditions
- Edema, Hypertension, Primary Aldosteronism, Primary Hyperaldosteronism, Secondary hyperaldosteronism, Chronic heart failure with reduced ejection fraction (NYHA Class III), Chronic heart failure with reduced ejection fraction (NYHA Class IV), Idiopathic hyperaldosteronism, Refractory Edema
- Associated Therapies
- Perioperative drug treatment, Maintenance therapy
Spironolactone in Diabetic Nephropathy
- Conditions
- Diabetic Nephropathy
- First Posted Date
- 2006-04-25
- Last Posted Date
- 2006-04-25
- Lead Sponsor
- Steno Diabetes Center Copenhagen
- Target Recruit Count
- 48
- Registration Number
- NCT00317954
- Locations
- 🇩🇰
Steno Diabetes Center, Gentofte, Denmark
Examining the Effect of Different Diuretics on Fluid Retention in Diabetics Treated With Rosiglitazone.
- Conditions
- Diabetes Mellitus
- First Posted Date
- 2006-03-24
- Last Posted Date
- 2016-09-15
- Lead Sponsor
- GlaxoSmithKline
- Target Recruit Count
- 388
- Registration Number
- NCT00306696
- Locations
- 🇬🇧
GSK Investigational Site, London, United Kingdom
Mineralocorticoid Receptor in the Treatment of Severe Depression
- Conditions
- Major Depression
- First Posted Date
- 2006-02-23
- Last Posted Date
- 2017-05-30
- Lead Sponsor
- Universitätsklinikum Hamburg-Eppendorf
- Target Recruit Count
- 65
- Registration Number
- NCT00295347
- Locations
- 🇩🇪
University Hospital Hamburg-Eppendorf, Hamburg, Germany
Is Spironolactone Safe and Effective in the Treatment of Cardiovascular Disease in Mild Chronic Renal Failure?
- Conditions
- Chronic Kidney DiseaseCardiovascular Disease
- Interventions
- Drug: Placebo
- First Posted Date
- 2006-02-14
- Last Posted Date
- 2008-05-21
- Lead Sponsor
- University Hospital Birmingham
- Target Recruit Count
- 120
- Registration Number
- NCT00291720
- Locations
- 🇬🇧
University Hospital Birmingham, Birmingham, West Midlands, United Kingdom
Cardiovascular Protective Effect of Spironolactone in Hemodialysis
- Conditions
- Hemodialysis
- First Posted Date
- 2006-01-16
- Last Posted Date
- 2006-01-16
- Lead Sponsor
- Universidad de los Andes, Chile
- Registration Number
- NCT00277693
- Locations
- 🇨🇱
Clinica Davila, Santiago, Chile
Spironolactone to Decrease Potassium Wasting in Hypercalciurics on Thiazides Diuretics
- Conditions
- Idiopathic HypercalciuriaHypokalemia Caused by Thiazide Diuretics
- First Posted Date
- 2006-01-13
- Last Posted Date
- 2009-12-03
- Lead Sponsor
- Indiana University School of Medicine
- Target Recruit Count
- 10
- Registration Number
- NCT00276289
- Locations
- 🇺🇸
Indiana University Department of Medicine, Division of Nephrology, Indianapolis, Indiana, United States
Spironolactone Combined With Captopril and Carvedilol for the Treatment of Pulmonary Arterial Hypertension
- Conditions
- Hypertension, Pulmonary
- First Posted Date
- 2005-10-18
- Last Posted Date
- 2008-06-30
- Lead Sponsor
- Hebei Medical University
- Registration Number
- NCT00240656
- Locations
- 🇨🇳
The First Hospital of Hebei Medical University, Shijiazhuang, Hebei, China
Clinical Trial Studying the Effects of Spironolactone on Heart and Skeletal Muscle Function in Chronic Alcoholics
- First Posted Date
- 2005-09-26
- Last Posted Date
- 2010-10-20
- Lead Sponsor
- University of Aarhus
- Target Recruit Count
- 40
- Registration Number
- NCT00226109
- Locations
- 🇩🇰
Department of Medicine V (gastroenterology and hepatology), Aarhus, Denmark
Impact of Medical and Surgical Therapy on Functional Mitral Regurgitation
- Conditions
- Heart DiseasesCardiovascular DiseasesCoronary Disease
- First Posted Date
- 2005-09-23
- Last Posted Date
- 2014-02-19
- Lead Sponsor
- Baylor Research Institute
- Target Recruit Count
- 250
- Registration Number
- NCT00224809
- Locations
- 🇺🇸
Baylor Research Institute, Dallas, Texas, United States
Spironolactone in Patients With Single Ventricle Heart
- First Posted Date
- 2005-09-21
- Last Posted Date
- 2017-11-06
- Lead Sponsor
- Emory University
- Target Recruit Count
- 12
- Registration Number
- NCT00211081
- Locations
- 🇺🇸
Emory Clinic, Atlanta, Georgia, United States
Drug Development Updates
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