Spironolactone
- Generic Name
- Spironolactone
- Brand Names
- Aldactazide, Aldactone, Carospir, Qaialdo
- Drug Type
- Small Molecule
- Chemical Formula
- C24H32O4S
- CAS Number
- 52-01-7
- Unique Ingredient Identifier
- 27O7W4T232
- Background
Spironolactone is a potassium-sparing diuretic. It binds to mineralocorticoid receptors and functions as aldosterone antagonists. It promotes sodium and water excretion and potassium retention. Spironolactone was originally developed purely for this ability before other pharmacodynamic properties of the drug were discovered. It is indicated to treat several ...
- Indication
Spironolactone is indicated for the treatment of the following conditions:
As spironolactone has antiandrogenic activity, its off-label uses include the treatment of hirsutism, female pattern hair loss, and adult acne vulgaris.
- Associated Conditions
- Edema, Hypertension, Primary Aldosteronism, Primary Hyperaldosteronism, Secondary hyperaldosteronism, Chronic heart failure with reduced ejection fraction (NYHA Class III), Chronic heart failure with reduced ejection fraction (NYHA Class IV), Idiopathic hyperaldosteronism, Refractory Edema
- Associated Therapies
- Perioperative drug treatment, Maintenance therapy
The Effect of Spironolactone on Acute Kidney Injury in Patients Undergoing Coronary Angiography
- Conditions
- Interventions
- First Posted Date
- 2017-11-06
- Last Posted Date
- 2018-09-10
- Lead Sponsor
- Alhasan Mujtaba Abdul-Wahid
- Target Recruit Count
- 490
- Registration Number
- NCT03329443
- Locations
- 🇮🇶
Al-Sader Teaching Hospital, Basrah, Iraq
Exploring Mechanisms and Morphology of QT Interval Prolongation
- Conditions
- Interventions
- First Posted Date
- 2017-09-25
- Last Posted Date
- 2019-02-21
- Lead Sponsor
- Herlev and Gentofte Hospital
- Target Recruit Count
- 28
- Registration Number
- NCT03291145
- Locations
- 🇩🇰
Herlev-Gentofte Hospital, Herlev, Copenhagen, Denmark
The Impact of Fitness and Mineralocorticoid Receptor Blockade on Vascular Dysfunction in Adults With Type 1 Diabetes
- First Posted Date
- 2017-06-02
- Last Posted Date
- 2019-12-18
- Lead Sponsor
- University of Virginia
- Target Recruit Count
- 32
- Registration Number
- NCT03174288
- Locations
- 🇺🇸
University of Virginia, Charlottesville, Virginia, United States
Spironolactone With Patiromer in the Treatment of Resistant Hypertension in Chronic Kidney Disease
- Conditions
- Interventions
- First Posted Date
- 2017-03-06
- Last Posted Date
- 2021-05-12
- Lead Sponsor
- Relypsa, Inc.
- Target Recruit Count
- 295
- Registration Number
- NCT03071263
- Locations
- 🇧🇬
Investigator Site 1402, Sofia, Bulgaria
🇺🇸Investigator Site 1022, Chicago, Illinois, United States
🇺🇸Investigator Site 1023, Miami Lakes, Florida, United States
Hyperandrogenemia and Altered Day-night LH Pulse Patterns
- Conditions
- Interventions
- First Posted Date
- 2017-03-03
- Last Posted Date
- 2023-11-02
- Lead Sponsor
- University of Virginia
- Target Recruit Count
- 32
- Registration Number
- NCT03068910
- Locations
- 🇺🇸
University of Virginia Clinical Research Unit, Charlottesville, Virginia, United States
Colchicine and Spironolactone in Patients With MI / SYNERGY Stent Registry
- First Posted Date
- 2017-02-09
- Last Posted Date
- 2024-10-14
- Lead Sponsor
- Population Health Research Institute
- Target Recruit Count
- 7264
- Registration Number
- NCT03048825
- Locations
- 🇺🇸
Central Cardiology, Bakersfield, California, United States
🇺🇸Medstar Washington Hospital Center, Washington, District of Columbia, United States
🇺🇸University of Illinois, Chicago, Illinois, United States
Evaluating the Effect of Spironolactone on Hypertrophic Cardiomyopathy
- First Posted Date
- 2016-10-31
- Last Posted Date
- 2018-05-09
- Target Recruit Count
- 260
- Registration Number
- NCT02948998
- Locations
- 🇨🇳
Xinhua Hospital, Shanghai Jiao Tong University School of Medicne, Shanghai, Shanghai, China
Spironolactone Initiation Registry Randomized Interventional Trial in Heart Failure With Preserved Ejection Fraction
- Conditions
- Interventions
- First Posted Date
- 2016-09-15
- Last Posted Date
- 2024-10-22
- Lead Sponsor
- Uppsala University
- Target Recruit Count
- 2000
- Registration Number
- NCT02901184
- Locations
- 🇺🇸
University of Alabama at Birmingham, Birmingham, Alabama, United States
🇺🇸Advanced Cardiovascular LLC, Alexander City, Alabama, United States
🇺🇸Banner - University Medical Group, Tucson, Arizona, United States
Spironolactone After Liver Transplant
- First Posted Date
- 2016-08-30
- Last Posted Date
- 2022-04-21
- Lead Sponsor
- Wake Forest University Health Sciences
- Target Recruit Count
- 30
- Registration Number
- NCT02883400
- Locations
- 🇺🇸
CHS, Charlotte, North Carolina, United States
Sequential Nephron Blockade vs. Dual Blockade Renin-angiotensin System + Bisoprolol in Resistant Arterial Hypertension
- Conditions
- Interventions
- First Posted Date
- 2016-07-14
- Last Posted Date
- 2019-04-05
- Lead Sponsor
- Sao Jose do Rio Preto Medical School
- Target Recruit Count
- 72
- Registration Number
- NCT02832973
- Locations
- 🇧🇷
Juan Carlos Yugar-Toledo, São José do Rio Preto, São Paulo, Brazil
Drug Development Updates
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