Spironolactone is a potassium-sparing diuretic. It binds to mineralocorticoid receptors and functions as aldosterone antagonists. It promotes sodium and water excretion and potassium retention. Spironolactone was originally developed purely for this ability before other pharmacodynamic properties of the drug were discovered. It is indicated to treat several ...
Spironolactone is indicated for the treatment of the following conditions:
As spironolactone has antiandrogenic activity, its off-label uses include the treatment of hirsutism, female pattern hair loss, and adult acne vulgaris.
National Institutes of Health Clinical Center, Bethesda, Maryland, United States
University Hospital Erlangen-Nürnberg, Erlangen, Germany
University Hospital Frankfurt, Frankfurt, Germany
University Hospital Wuerzburg, Wuerzburg, Germany
Shibukawa Clinic, Shizuoka, Japan
University of São Paulo General Hospital, São Paulo, Brazil
Odense University Hospital, Odense C, Denmark
Orange Country Research Center, Tustin, California, United States
Montreal Heart Institute, Montreal, Quebec, Canada
Hotel-Dieu of Paris, Paris, France
Pfizer Investigational Site, New York, New York, United States
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