Colistin
- Generic Name
- Colistin
- Brand Names
- Cortisporin-TC
- Drug Type
- Small Molecule
- Chemical Formula
- C52H98N16O13
- CAS Number
- 1066-17-7
- Unique Ingredient Identifier
- Z67X93HJG1
- Background
Cyclic polypeptide antibiotic from Bacillus colistinus. It is composed of Polymyxins E1 and E2 (or Colistins A, B, and C) which act as detergents on cell membranes. Colistin is less toxic than Polymyxin B, but otherwise similar; the methanesulfonate is used orally.
- Indication
For the treatment of acute or chronic infections due to sensitive strains of certain gram-negative bacilli, particularly Pseudomonas aeruginosa.
- Associated Conditions
- Ear infection bacterial, External ear infection NOS
- Associated Therapies
- -
Nebulized Colistin for Gram Negative VAP Prevention.
- Conditions
- Interventions
- First Posted Date
- 2019-12-23
- Last Posted Date
- 2019-12-23
- Lead Sponsor
- University of Thessaly
- Target Recruit Count
- 152
- Registration Number
- NCT04208945
- Locations
- 🇬🇷
Evangelismos University Hospital of Athens, Athens, Greece
🇬🇷General Hospital of Volos Thessaly, Volos, Thessaly, Greece
🇬🇷University Hospital of Larisa, Larisa, Greece/Thessaly, Greece
A Randomized Controlled Trial Comparing Imipenem and Tigecycline Versus Imipenem and Tigecycline With GM-CSF for the Management of Spontaneous Bacterial Peritonitis Presenting With Septic Shock.
- Conditions
- Interventions
- First Posted Date
- 2019-12-23
- Last Posted Date
- 2021-02-16
- Lead Sponsor
- Institute of Liver and Biliary Sciences, India
- Target Recruit Count
- 90
- Registration Number
- NCT04208763
- Locations
- 🇮🇳
Institute of Liver and Biliary Sciences, New Delhi, Delhi, India
Study to Evaluate the Efficacy and Safety of Intravenous Sulbactam-ETX2514 in the Treatment of Patients With Infections Caused by Acinetobacter Baumannii-calcoaceticus Complex
- First Posted Date
- 2019-03-28
- Last Posted Date
- 2023-02-01
- Lead Sponsor
- Entasis Therapeutics
- Target Recruit Count
- 207
- Registration Number
- NCT03894046
- Locations
- 🇹🇷
Entasis Research Site 2, Ankara, Turkey
🇷🇺Entasis Research Site 3, Novosibirsk, Russian Federation
🇹🇷Entasis Research Site, Trabzon, Turkey
The Effect of Colistin Inhalation on Ventilator Associated Pneumonia
- Conditions
- Interventions
- First Posted Date
- 2018-08-09
- Last Posted Date
- 2018-08-09
- Lead Sponsor
- Nourhan Hassan Osama Thuraya Mohamed
- Target Recruit Count
- 40
- Registration Number
- NCT03622450
Combined Dry Powder Tobramycin and Nebulized Colistin Inhalation in CF Patients
- Conditions
- Interventions
- First Posted Date
- 2017-11-14
- Last Posted Date
- 2017-11-14
- Lead Sponsor
- University Hospital Tuebingen
- Target Recruit Count
- 26
- Registration Number
- NCT03341741
IV Colistin for Pulmonary Exacerbations: Improving Safety and Efficacy
- First Posted Date
- 2016-09-29
- Last Posted Date
- 2023-04-21
- Lead Sponsor
- National Jewish Health
- Target Recruit Count
- 51
- Registration Number
- NCT02918409
- Locations
- 🇺🇸
National Jewish Health, Denver, Colorado, United States
Impact of Treatment With Colistin on Mortality Bacteremia Multiresistant Acinetobacter Baumannii Sensitive Colistin in Patients Critical
- Conditions
- First Posted Date
- 2015-10-09
- Last Posted Date
- 2015-10-09
- Target Recruit Count
- 113
- Registration Number
- NCT02573064
Eradication of Antibiotic-resistant Bacteria Through Antibiotics and Fecal Bacteriotherapy
- First Posted Date
- 2015-06-16
- Last Posted Date
- 2017-12-07
- Lead Sponsor
- Stephen Harbarth
- Target Recruit Count
- 39
- Registration Number
- NCT02472600
- Locations
- 🇫🇷
Assistance Publique-Hôpitaux de Paris, Hôpital Beaujon, Clichy, France
🇳🇱Universitair Medisch Centrum Utrecht,, Utrecht, Netherlands
🇨🇭Geneva University Hospitals, Geneva, Switzerland
Efficacy and Mortality of a Loading Dose of Colistin in Critical Ill Patients
- First Posted Date
- 2014-04-21
- Last Posted Date
- 2018-03-13
- Lead Sponsor
- Hospital Barros Luco Trudeau
- Target Recruit Count
- 200
- Registration Number
- NCT02117986
- Locations
- 🇨🇱
Hospital Barros Luco Trudeau, Santiago, Region Metropolitana, Chile
🇨🇱Hospital de Puerto Montt, Puerto Montt, Chile
Colistin Pharmacokinetics in Continuous Renal Replacement Therapy
- First Posted Date
- 2014-03-07
- Last Posted Date
- 2014-03-07
- Lead Sponsor
- University of Zurich
- Target Recruit Count
- 10
- Registration Number
- NCT02081560
- Locations
- 🇨🇭
University Hospital of Zurich, Dept. of Pharmacology and Toxicology, Zurich, ZH, Switzerland
Drug Development Updates
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