Remimazolam
- Generic Name
- Remimazolam
- Brand Names
- Byfavo
- Drug Type
- Small Molecule
- Chemical Formula
- C21H19BrN4O2
- CAS Number
- 308242-62-8
- Unique Ingredient Identifier
- 7V4A8U16MB
- Background
Remimazolam is an ultra short-acting benzodiazepine used in the induction and maintenance of sedation during short (<30 minute) procedures. Recent trends in anesthesia-related drug development have touted the benefits of so-called "soft drugs" - these agents, such as remifentanil, are designed to be metabolically fragile and thus susceptible to rapid biotransformation and elimination as inactive metabolites. These "soft drugs" are useful in the context of surgical procedures, wherein a rapid onset/offset is desirable, enabling anesthesiologists to manipulate drug concentrations as needed. Remimazolam was the first "soft" benzodiazepine analog to be developed and was approved for use by the FDA in July 2020 under the brand name Byfavo.
- Indication
Remimazolam is indicated for the induction and maintenance of procedural sedation in adults undergoing procedures lasting 30 minutes or less.
- Associated Conditions
- Procedural Sedation
Effective Dose of Remimazolam for Sedation in Patients Undergoing Lower Extremity Surgery Under Spinal Anesthesia
- Conditions
- SedativesRemimazolamOrthopedic ProceduresAnesthesia, Spinal
- Interventions
- First Posted Date
- 2022-05-18
- Last Posted Date
- 2022-12-19
- Lead Sponsor
- Asan Medical Center
- Target Recruit Count
- 51
- Registration Number
- NCT05379777
- Locations
- 🇰🇷
Asan Medical Center, Seoul, Korea, Republic of
Remimazolam Versus Propopol Based Total Intravenous Anesthesia for Breast Surgery
- First Posted Date
- 2022-05-17
- Last Posted Date
- 2024-11-28
- Lead Sponsor
- Seoul National University Hospital
- Registration Number
- NCT05375747
- Locations
- 🇰🇷
Seoul National University Hospital, Seoul, Korea, Republic of
The Application of Remazolam in Gastroenteroscopy
- First Posted Date
- 2022-05-02
- Last Posted Date
- 2025-02-19
- Lead Sponsor
- Yangzhou University
- Target Recruit Count
- 83
- Registration Number
- NCT05357430
- Locations
- 🇨🇳
Affiliated Hospital of Yangzhou University, Yangzhou, Jiangsu, China
Quality of Recovery of Remimazolam Versus Sevoflurane in Transurethral Bladder Resection.
- First Posted Date
- 2022-05-02
- Last Posted Date
- 2023-03-09
- Lead Sponsor
- Kangbuk Samsung Hospital
- Target Recruit Count
- 36
- Registration Number
- NCT05356091
- Locations
- 🇰🇷
Eunah Cho, Seoul, Korea, Republic of
Remimazolam in the Extraction of Impacted Wisdom Teeth
- Conditions
- Dental AnxietySedation ComplicationAnterograde Amnesia
- Interventions
- First Posted Date
- 2022-04-27
- Last Posted Date
- 2023-04-07
- Lead Sponsor
- Peking Union Medical College Hospital
- Target Recruit Count
- 150
- Registration Number
- NCT05350085
- Locations
- 🇨🇳
Peking Union Medical College Hospital, Beijing, China
ED90 of Remimazolam Loading Dose for Sedation in Patients Under Monitored Anesthetic Care
- First Posted Date
- 2022-04-22
- Last Posted Date
- 2022-07-21
- Lead Sponsor
- Asan Medical Center
- Target Recruit Count
- 50
- Registration Number
- NCT05340335
- Locations
- 🇰🇷
Asan Medical Center, Seoul, Korea, Republic of
Remimazolam Total Intravenous Anesthesia Under Analgesia Nociception Index-guidance
- Conditions
- Knee OsteoarthritisTotal Knee ArthroplastyRemimazolam
- Interventions
- First Posted Date
- 2022-04-12
- Last Posted Date
- 2023-07-19
- Lead Sponsor
- Gangnam Severance Hospital
- Target Recruit Count
- 84
- Registration Number
- NCT05322902
- Locations
- 🇰🇷
Gangnam Severance Hospital, Seoul, Korea, Republic of
Effects of Remimazolam on Quality of Recovery After Ambulatory Surgery
- Conditions
- Quality of RecoveryDay SurgeryPatient Outcome AssessmentRemimazolam
- First Posted Date
- 2022-04-11
- Last Posted Date
- 2022-04-11
- Lead Sponsor
- Seoul National University Bundang Hospital
- Target Recruit Count
- 38
- Registration Number
- NCT05320016
- Locations
- 🇰🇷
Seoul National University Bundang Hospital, Seongnam-si, Gyunggi-do, Korea, Republic of
Sedation With Remimazolam During Spinal Anesthesia
- Conditions
- SedationSpinal Anesthesia
- Interventions
- First Posted Date
- 2022-03-31
- Last Posted Date
- 2023-05-12
- Lead Sponsor
- Gangnam Severance Hospital
- Target Recruit Count
- 62
- Registration Number
- NCT05305248
- Locations
- 🇰🇷
Gangnam Severance Hospital, Seoul, Korea, Republic of
Dose Finding Study of Remimazolam for Laryngeal Mask Airway Insertion
- First Posted Date
- 2022-03-28
- Last Posted Date
- 2022-03-28
- Lead Sponsor
- Yonsei University
- Target Recruit Count
- 25
- Registration Number
- NCT05298228
- Locations
- 🇰🇷
Yonsei University Health System, Severance Hospital, Seoul, Korea, Republic of
Drug Development Updates
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