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Sucralfate

Generic Name
Sucralfate
Brand Names
Carafate, Sulcrate
Drug Type
Small Molecule
Chemical Formula
C12H35Al9O55S8
CAS Number
54182-58-0
Unique Ingredient Identifier
XX73205DH5
Background

Sucralfate is a medication that is widely used to prevent and treat a number of diseases in the gastrointestinal tract such as duodenal ulcers , gastro-esophageal reflux disease (GERD), gastritis, peptic ulcer disease, stress ulcer, in addition to dyspepsia . It is considered a cytoprotective agent, protecting cells in the gastrointestinal tract from damage caused by agents such as gastric acid, bile salts, alcohol, and acetylsalicylic acid (aspirin), among other substances .

Sucralfate has been shown to be a well-tolerated and safe drug. It is sold under many brands and is available in both tablet and suspension forms. It was approved by the FDA 1982 in tablet form, and in 1994 for the suspension form .

Indication

The sucralfate suspension and tablet are used for the treatment of active duodenal ulcer for up to 8 weeks. The tablet form may be used at a lower dose for healed duodenal ulcers, for the purpose of maintaining healing and preventing recurrence .

Sucralfate is also used in the prevention and/or treatment of gastro-esophageal reflux disease (GERD), gastritis, peptic ulcer disease, stress ulcer, in addition to dyspepsia .

Associated Conditions
Dyspepsia, Gastric Ulcer, Gastritis, Gastro-esophageal Reflux Disease (GERD), Healing, Mucositis, Peptic Ulcer, Stress Ulcers, Active Duodenal ulcer
Associated Therapies
Anti-platelet Therapy

Short-Term Outcome of Medical Vs. Surgical Management Of Chronic Anal Fissure

Phase 1
Completed
Conditions
Anal Fissure Chronic
Interventions
Drug: Sucralfate
Drug: Azadirachtin
Procedure: fissurectomy and lateral sphincterectomy
First Posted Date
2024-09-27
Last Posted Date
2024-11-08
Lead Sponsor
Suez Canal University
Target Recruit Count
99
Registration Number
NCT06617026
Locations
🇪🇬

Suez Canal University, Ismailia, Egypt

Prevention of Post-sphincterotomy Bleeding

Not Applicable
Recruiting
Conditions
Post-ERCP Bleeding
Interventions
First Posted Date
2023-10-30
Last Posted Date
2024-12-20
Lead Sponsor
National Cheng-Kung University Hospital
Target Recruit Count
120
Registration Number
NCT06107504
Locations
🇨🇳

National Cheng-Kung University Hospital, Tainan, Other (Non U.s.), Taiwan

Colonoscopic Sucralfate Spray in Prevention of Delayed Polypectomy Bleeding

Phase 1
Recruiting
Conditions
Bleeding
Interventions
First Posted Date
2023-04-18
Last Posted Date
2023-12-22
Lead Sponsor
National Cheng-Kung University Hospital
Target Recruit Count
160
Registration Number
NCT05817656
Locations
🇨🇳

Hsueh-Chien Chiang, Tainan, Other (Non U.s.), Taiwan

Reducing Acute Upper Gastrointestinal Side-Effects of Thoracic Irradiation

Phase 2
Recruiting
Conditions
Radiation Esophagitis
Interventions
Other: Usual Care
Other: Two consent
Other: One consent
Drug: Sucralfate
First Posted Date
2022-12-21
Last Posted Date
2024-10-03
Lead Sponsor
Memorial Sloan Kettering Cancer Center
Target Recruit Count
352
Registration Number
NCT05659576
Locations
🇺🇸

Memorial Sloan Kettering Cancer Center (All Protocol Activities), New York, New York, United States

🇺🇸

Memorial Sloan Kettering Suffolk-Commack (All Protocol Activities ), Commack, New York, United States

🇺🇸

Memorial Sloan Kettering Nassau (All Protocol Activities), Uniondale, New York, United States

and more 4 locations

Effects of Oral Aloe Vera Juice on Chemotherapy and Radiation-induced Oral Mucositis and Esophagitis

Phase 3
Completed
Conditions
Oropharynx Cancer
Esophageal Cancer
Chest Wall Tumor
Radiation Mucositis
Oral Cavity Cancer
Head and Neck Cancers - Tonsils
Mediastinal Cancer
Laryngeal Cancer
Interventions
Dietary Supplement: 100% Aloe Vera Juice
Combination Product: Magic Mouthwash
Combination Product: Salt and Baking soda rinse
Drug: Carafate
First Posted Date
2022-05-11
Last Posted Date
2024-10-10
Lead Sponsor
Thompson Cancer Survival Center
Target Recruit Count
100
Registration Number
NCT05369234
Locations
🇺🇸

Thompson Cancer Survival Center Radiation Oncology Services, Knoxville, Tennessee, United States

A Comparison of Effectiveness of Oral Sucrolfate, Alginate and Hydrotalcide in Dispeptic Pain Treatment

Phase 4
Completed
Conditions
Dyspepsia
Interventions
First Posted Date
2018-08-17
Last Posted Date
2018-08-31
Lead Sponsor
Pamukkale University
Target Recruit Count
300
Registration Number
NCT03635372
Locations
🇹🇷

Pamukkale University, Denizli, Turkey

Sucralfate to Improve Oral Intake in Children With Infectious Oral Ulcers: a Randomized, Double-blind, Placebo-Controlled Trial

Phase 2
Completed
Conditions
Hand, Foot and Mouth Disease
Herpangina
Gingivostomatitis
Interventions
First Posted Date
2017-08-07
Last Posted Date
2021-10-29
Lead Sponsor
University of Texas at Austin
Target Recruit Count
102
Registration Number
NCT03241030
Locations
🇺🇸

Dell Children's Medical Center, Austin, Texas, United States

Confocal Endomicroscopy for Non-Erosive Reflux Disease Detection

Not Applicable
Terminated
Conditions
Non-erosive Reflux Disease
Gastroesophageal Reflux
Interventions
Drug: Proton Pump Inhibitor (PPI) Therapy
Drug: Sucralfate
First Posted Date
2016-06-02
Last Posted Date
2022-02-09
Lead Sponsor
LCMC Health
Target Recruit Count
5
Registration Number
NCT02788591
Locations
🇺🇸

Touro Infirmary New Orleans, New Orleans, Louisiana, United States

🇺🇸

University Medical Center New Orleans, New Orleans, Louisiana, United States

The Effect of Sucralfate Slurry in Patients With Eosinophilic Esophagitis

Early Phase 1
Completed
Conditions
Eosinophilic Esophagitis
Interventions
Drug: Sucralfate
Device: Intraluminal Impedance
First Posted Date
2015-02-02
Last Posted Date
2017-10-11
Lead Sponsor
Mayo Clinic
Target Recruit Count
3
Registration Number
NCT02353078
Locations
🇺🇸

Mayo Clinic in Rochester, Rochester, Minnesota, United States

Confocal Endomicroscopy for Non-Erosive Reflux Disease (CE NERD)

Not Applicable
Withdrawn
Conditions
Non Erosive Reflux Disease
Gastroesophageal Reflux Disease
Dyspepsia
Interventions
Device: Confocal endomicroscopy
Drug: Proton pump inhibitor
Drug: Sucralfate
First Posted Date
2014-01-20
Last Posted Date
2015-12-09
Lead Sponsor
Virginia Commonwealth University
Registration Number
NCT02039869
Locations
🇺🇸

Medical University of South Carolina, Charleston, South Carolina, United States

🇺🇸

Ochsner Medical Center, Kenner, Louisiana, United States

🇺🇸

Virginia Commonwealth University, Richmond, Virginia, United States

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