Tramadol is a centrally acting synthetic opioid analgesic and SNRI (serotonin/norepinephrine reuptake-inhibitor) that is structurally related to codeine and morphine. Due to its good tolerability profile and multimodal mechanism of action, tramadol is generally considered a lower-risk opioid option for the treatment of moderate to severe pain. It is consider...
Tramadol is approved for the management of moderate to severe pain in adults.
Tramadol is also used off-label in the treatment of premature ejaculation.
Elena Nikolakopoulou, Athens, Kifissia, Greece
CHU de Nimes, Nîmes, France
Rothman Institute, Philadelphia, Pennsylvania, United States
Department of Nutrition, Exercise and Sports, Copenhagen, Denmark
University Heart Center Zurich, Zurich, Switzerland
Seoul National University Hospital, Seoul, Korea, Republic of
Lotus Clinical Research, Pasadena, California, United States
Hermann Drive Research, Houston, Texas, United States
Endeavor Clinical Trials, San Antonio, Texas, United States
faculty of medicine Cairo university, Giza, Egypt
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