Gentamicin

Generic Name: Gentamicin

Brand Names: Gentak, Pred-G, Valisone-G

Drug Type: Small Molecule

Chemical Formula: C_₆₀H_₁₂₃N_₁₅O_₂₁

CAS Number: 1403-66-3

Unique Ingredient Identifier: T6Z9V48IKG

Background: Gentamicin is a bactericidal aminoglycoside that was discovered and isolated from Micromonospora purpurea in 1963. It is one of the most frequently prescribed aminoglycosides due to its spectrum of activity, low cost, and availability. Gentamicin is effective against both gram-positive and gram-negative organisms but is particularly useful for the treatment ...

Indication: 1.本品适用于敏感铜绿假单胞菌、变形杆菌（吲哚阳性和阴性）属、大肠埃希菌、克雷伯菌属、肠杆菌属、沙雷菌属、柠檬酸杆菌属以及葡萄球菌属（不包括耐甲氧西林菌株）所致的严重感染；临床上本品常与β内酰胺类或其他抗菌药物联合应用。本品与青霉素G（或氨苄西林）联合应用治疗肠球菌感染；

2.本品用于铜绿假单胞菌或葡萄球菌属所致的严重中枢神经系统感染（如脑膜炎、脑室炎）时，可同时用本品鞘内注射作为辅助治疗；

3.本品不适用于单纯性尿路感染初治，除非病原菌对其他毒性较低的抗菌药物不敏感，本品对链球菌属中多数菌种（尤其D组）、肺炎链球菌和厌氧菌（如拟杆菌属或梭状芽孢杆菌属）无效；

4.本品口服可用于肠道感染或结肠手术前准备，也可用本品肌注合并克林霉素或甲硝唑以减少结肠手术后感染率。
...

Associated Conditions: Allergic Conjunctivitis (AC), Bacterial Conjunctivitis, Bacterial Infections, Bacterial Keratitis, Bacterial Peritonitis, Bacterial dacryocystitis, Blepharoconjunctivitis, Central Nervous System Infections, Corneal infection, Dermatitis infected, Ecthyma, Eczematous dermatitis infected, Folliculitis, Furunculosis, Gram-negative enteric bacilli neonatal sepsis, Impetigo contagious, Inflammation, Keratoconjunctivitis, Meibomianitis, Meningitis, Bacterial, Ocular Inflammation, Pustular Psoriasis (PP), Pustular acne, Pyoderma Gangrenosum, Seborrheic Dermatitis, Septicemia gram-negative, Skin Infections, Skin and Subcutaneous Tissue Bacterial Infections, Sycosis barbae, Bacterial blepharitis, Bacterial corneal ulcers, Bacterial skin infections, Complicated Respiratory tract infection bacterial, Complicated Urinary Tract Infection caused by susceptible bacteria, Corticosteroid-responsive dermatoses, Ocular bacterial infections, Severe Endocarditis enterococcal, Severe Infection Pseudomonas aeruginosa, Severe Staphylococcal infection

Associated Therapies: -

Clinical Trials

A Randomized Trial of Preoperative Prophylactic Antibiotics Prior to Kidney Stone Surgery (Percutaneous Nephrolithotomy [PCNL])

Phase 4

Completed

Conditions: Nephrolithiasis
Urinary Tract Infections

Interventions: Drug: nitrofurantoin monohydrate/macrocrystalline capsules
Drug: ampicillin
Drug: gentamicin
Drug: vancomycin
Drug: ceftriaxone

First Posted Date: 2015-03-10

Last Posted Date: 2019-08-22

Lead Sponsor: University of California, San Diego

Target Recruit Count: 86

Registration Number: NCT02384200

Locations: 🇺🇸
Mayo Clinic in Arizona, Phoenix, Arizona, United States
🇺🇸
UCSD Medical Center, San Diego, California, United States
🇺🇸
The Ohio State University Wexner Medical Center, Columbus, Ohio, United States

and more 5 locations

Pharmacokinetics of an Aminoglycoside in Hemodialysis Patients.

Phase 4

Terminated

Conditions: Renal Failure Chronic Requiring Hemodialysis

Interventions: Drug: Gentamicin

First Posted Date: 2013-11-13

Last Posted Date: 2020-07-17

Lead Sponsor: University Hospital, Limoges

Target Recruit Count: 24

Registration Number: NCT01982864

Locations: 🇫🇷
CHU LIMOGES - Service Néphrologie, Limoges, France
🇫🇷
CHU LIMOGES - Laboratoire de Pharmacologie, Limoges, France

Prophylactic Antibiotics for Manual Removal of Retained Placenta in Vaginal Birth: a Randomized Controlled Trial

Not Applicable

Conditions: Endometritis

Interventions: Drug: Antibiotic prophylaxis
Drug: Ampicillin
Drug: Gentamycin
Drug: Clindamycin

First Posted Date: 2013-09-18

Last Posted Date: 2013-11-27

Lead Sponsor: Hadassah Medical Organization

Target Recruit Count: 300

Registration Number: NCT01945450

Locations: 🇮🇱
Hadassah Medical Organization, Jerusalem, Israel

Gentamicin Bladder Instillation Trial

Phase 4

Conditions: Urinary Tract Infections

Interventions: Drug: Placebo
Drug: Gentamicin

First Posted Date: 2013-06-24

Last Posted Date: 2015-04-09

Lead Sponsor: Gillette Children's Specialty Healthcare

Target Recruit Count: 24

Registration Number: NCT01884467

Locations: 🇺🇸
Gillette Lifetime Specialty Healthcare, Saint Paul, Minnesota, United States

Antibiotic Prophylaxis for Transrectal Prostate Biopsy

Phase 4

Completed

Conditions: Infection

Interventions: Drug: trimethoprim-sulfamethoxazole
Drug: Ciprofloxacin
Drug: cefuroxime
Drug: ceftriaxone
Drug: gentamicin
Drug: amikacin
Drug: aztreonam
Drug: imipenem

First Posted Date: 2012-08-08

Last Posted Date: 2019-06-25

Lead Sponsor: Northwestern University

Target Recruit Count: 563

Registration Number: NCT01659866

Locations: 🇺🇸
Northwestern University Department of Urology, Chicago, Illinois, United States

Effectiveness of Topical Antibiotic Prophylaxis in Inguinal Hernia Repair

Phase 4

Completed

Conditions: Inguinal Hernia

Interventions: Drug: Cefazolin
Drug: Gentamicin and cefazolin
Drug: Gentamicin

First Posted Date: 2011-01-11

Last Posted Date: 2014-12-29

Lead Sponsor: Diskapi Teaching and Research Hospital

Target Recruit Count: 276

Registration Number: NCT01273818

Locations: 🇹🇷
Diskapi Yildirim Beyazit Teaching and research Hospital, Ankara, Turkey

Gentamicin in Preventing Post Endoscopic Retrograde Cholangiopancreatography (ERCP) Cholangitis in Non-calculus Stenting

Not Applicable

Completed

Conditions: Cholangitis

Interventions: Drug: gentamicin
Drug: Placebo

First Posted Date: 2010-06-22

Last Posted Date: 2011-09-20

Lead Sponsor: Tehran University of Medical Sciences

Target Recruit Count: 114

Registration Number: NCT01148693

Locations: 🇮🇷
TUMS Digestive Disease Research Center, Tehran, Iran, Islamic Republic of

Efficacy of Combination Therapies for Gonorrhea Treatment

Phase 4

Completed

Conditions: Gonorrhoea

Interventions: Drug: Azithromycin
Drug: Gemifloxacin
Drug: Gentamicin

First Posted Date: 2009-06-24

Last Posted Date: 2015-08-19

Lead Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Target Recruit Count: 614

Registration Number: NCT00926796

Locations: 🇺🇸
San Francisco Department of Public Health - San Francisco City Clinic, San Francisco, California, United States
🇺🇸
University of Alabama Hospital - Infectious Diseases, Birmingham, Alabama, United States
🇺🇸
Los Angeles County Department of Public Health - Sexually Transmitted Disease Program, Los Angeles, California, United States

and more 2 locations