Midodrine

Generic Name: Midodrine

Brand Names: Proamatine

Drug Type: Small Molecule

Chemical Formula: C_₁₂H_₁₈N_₂O_₄

CAS Number: 42794-76-3

Unique Ingredient Identifier: 6YE7PBM15H

Background: An ethanolamine derivative that is an adrenergic alpha agonist. It is used as a vasoconstrictor agent in the treatment of hypotension.

Indication: For the treatment of symptomatic orthostatic hypotension (OH).

Associated Conditions: Symptomatic Orthostatic Hypotension

Associated Therapies: -

Clinical Trials

Minimization of Intradialytic Hypotension Using Cardiography-Guided Intervention

Phase 4

Conditions: Intradialytic Hypotension

Interventions: Device: pressure stockings
Drug: Midodrine
Other: pressure stockings and midodrine

First Posted Date: 2017-03-15

Last Posted Date: 2017-03-15

Lead Sponsor: Nimedical

Target Recruit Count: 35

Registration Number: NCT03080441

Midodrine in the Recovery Phase of Septic Shock

Phase 3

Withdrawn

Conditions: Septic Shock

Interventions: Other: Standard of Care
Drug: midodrine

First Posted Date: 2016-12-13

Last Posted Date: 2024-01-11

Lead Sponsor: University of Virginia

Registration Number: NCT02990546

Locations: 🇺🇸
University of Virginia, Charlottesville, Virginia, United States

Effects of Midodrine and Droxidopa on Splanchnic Capacitance in Autonomic Failure

Phase 1

Recruiting

Conditions: Pure Autonomic Failure
Autonomic Failure
Multiple System Atrophy
Parkinson Disease
Orthostatic Hypotension

Interventions: Drug: Midodrine
Drug: Droxidopa
Drug: Placebo

First Posted Date: 2016-09-12

Last Posted Date: 2024-12-12

Lead Sponsor: Vanderbilt University Medical Center

Target Recruit Count: 34

Registration Number: NCT02897063

Locations: 🇺🇸
Autonomic Dysfunction Center/ Vanderbilt University Medical Center, Nashville, Tennessee, United States

Midodrine During Recovery From Septic Shock

Phase 4

Withdrawn

Conditions: Hypotension
Sepsis
Shock, Septic

Interventions: Drug: placebo
Drug: Midodrine

First Posted Date: 2016-05-12

Last Posted Date: 2017-11-06

Lead Sponsor: Northwell Health

Registration Number: NCT02771158

Hemodynamic Mechanisms of Abdominal Compression in the Treatment of Orthostatic Hypotension in Autonomic Failure

Phase 1

Recruiting

Conditions: Multiple System Atrophy
Orthostatic Hypotension
Autonomic Failure
Pure Autonomic Failure

Interventions: Other: Abdominal compression
Other: Sham abdominal compression
Drug: Placebo pill
Drug: midodrine

First Posted Date: 2015-04-29

Last Posted Date: 2024-03-26

Lead Sponsor: Vanderbilt University Medical Center

Target Recruit Count: 29

Registration Number: NCT02429557

Locations: 🇺🇸
Vanderbilt University, Nashville, Tennessee, United States

Midodrine for Ischemic Stroke With Penumbra

Withdrawn

Conditions: Stroke

Interventions: Drug: Midodrine

First Posted Date: 2015-03-09

Last Posted Date: 2017-05-17

Lead Sponsor: University of Utah

Registration Number: NCT02383121

Locations: 🇺🇸
University of Utah, Salt Lake City, Utah, United States

Treatment of Orthostatic Intolerance in Patients With Parkinson's Disease Using Midodrine

Not Applicable

Conditions: Orthostatic Intolerance
Parkinson's Disease

Interventions: Drug: Midodrine

First Posted Date: 2015-02-18

Last Posted Date: 2015-08-26

Lead Sponsor: Corporal Michael J. Crescenz VA Medical Center

Target Recruit Count: 50

Registration Number: NCT02365012

Locations: 🇺🇸
PVAMC, Philadelphia, Pennsylvania, United States

Treatment and Prognosis of Neurogenic Orthostatic Hypotension : A Prospective Randomized Study

Phase 4

Completed

Conditions: Orthostatic; Hypotension, Neurogenic

Interventions: Drug: Midodrine + pyridostigmine
Drug: Midodrine
Drug: Pyridostigmine Bromide

First Posted Date: 2014-12-04

Last Posted Date: 2021-10-19

Lead Sponsor: Seoul National University Hospital

Target Recruit Count: 87

Registration Number: NCT02308124

Locations: 🇰🇷
Seoul National University Hospital, Seoul, Korea, Republic of

Blood Pressure, Cerebral Blood Flow and Cognition in Spinal Cord Injury

Phase 3

Completed

Conditions: Spinal Cord Injury

Interventions: Drug: Midodrine
Drug: Placebo

First Posted Date: 2014-12-04

Last Posted Date: 2023-06-28

Lead Sponsor: James J. Peters Veterans Affairs Medical Center

Target Recruit Count: 60

Registration Number: NCT02307565

Locations: 🇺🇸
James J Peters VAMC, Bronx, New York, United States
🇺🇸
Kessler Foundation Research Center, West Orange, New Jersey, United States

Role of Midodrine and Tolvaptan in Patients With Cirrhosis With Refractory or Recurrent Ascites

Phase 2

Completed

Conditions: Refractory/Recurrent Ascites
Cirrhosis

Interventions: Drug: Standard medical therapy
Drug: Midodrine
Drug: Tolvaptan

First Posted Date: 2014-06-24

Last Posted Date: 2017-09-19

Lead Sponsor: Post Graduate Institute of Medical Education and Research, Chandigarh

Target Recruit Count: 50

Registration Number: NCT02173288

Locations: 🇮🇳
Dept. of Hepatology, PGIMER, Chandigarh, Chandigarh, India

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