Midodrine

Generic Name: Midodrine

Brand Names: Proamatine

Drug Type: Small Molecule

Chemical Formula: C_₁₂H_₁₈N_₂O_₄

CAS Number: 42794-76-3

Unique Ingredient Identifier: 6YE7PBM15H

Background: An ethanolamine derivative that is an adrenergic alpha agonist. It is used as a vasoconstrictor agent in the treatment of hypotension.

Indication: For the treatment of symptomatic orthostatic hypotension (OH).

Associated Conditions: Symptomatic Orthostatic Hypotension

Associated Therapies: -

Clinical Trials

Midodrine for the Early Liberation of Vasopressor Support in the ICU

Phase 4

Completed

Conditions: Shock
Critical Illness

Interventions: Drug: Placebo
Drug: Midodrine

First Posted Date: 2020-07-28

Last Posted Date: 2023-10-06

Lead Sponsor: University of Alberta

Target Recruit Count: 20

Registration Number: NCT04489589

Locations: 🇨🇦
University of Alberta Hospital, Edmonton, Alberta, Canada

Efficacy of Combination of Midodrine With Propranolol in Preventing First Bleed in Decompensated Cirrhotics With Severe Ascites.

Not Applicable

Completed

Conditions: Decompensated Cirrhosis
Severe Ascites

Interventions: Drug: Propranolol
Drug: Midodrine

First Posted Date: 2019-12-23

Last Posted Date: 2024-03-20

Lead Sponsor: Institute of Liver and Biliary Sciences, India

Target Recruit Count: 140

Registration Number: NCT04208776

Locations: 🇮🇳
Institute of Liver and Biliary Sciences, New Delhi, Delhi, India

Angiotensin 2 for Hepatorenal Syndrome

Phase 2

Withdrawn

Conditions: Hepatorenal Syndrome
Cirrhosis
Kidney Failure, Acute

Interventions: Drug: Midodrine
Drug: Angiotensin II
Drug: Octreotide
Drug: Albumin solution

First Posted Date: 2019-08-07

Last Posted Date: 2024-03-06

Lead Sponsor: University of California, Los Angeles

Registration Number: NCT04048707

Impact of Midodrine Administration on the Clinical Outcome of Septic Shock Patients

Phase 4

Completed

Conditions: Septic Shock

Interventions: Drug: Midodrine

First Posted Date: 2019-04-11

Last Posted Date: 2020-01-09

Lead Sponsor: Ain Shams University

Target Recruit Count: 60

Registration Number: NCT03911817

Locations: 🇪🇬
Critical Care Medicine Department - Cairo University Hospitals, Cairo, Egypt

To Study the Safety and Efficacy of Midodrine With Albumin Versus Albumin Alone in Hepatic Hydrothorax

Not Applicable

Completed

Conditions: Hepatic Hydrothorax

Interventions: Drug: Midodrine
Drug: Diuretics
Biological: Albumin

First Posted Date: 2018-08-24

Last Posted Date: 2020-06-25

Lead Sponsor: Institute of Liver and Biliary Sciences, India

Target Recruit Count: 8

Registration Number: NCT03645642

Locations: 🇮🇳
Institute of Liver and Biliary Sciences, New Delhi, Delhi, India

Midodrine in Hepatopulmonary Syndrome

Phase 1

Completed

Conditions: Hepatopulmonary Syndrome (HPS)

Interventions: Drug: Midodrine

First Posted Date: 2018-07-26

Last Posted Date: 2021-01-06

Lead Sponsor: Mayo Clinic

Target Recruit Count: 10

Registration Number: NCT03600870

Locations: 🇺🇸
Mayo Clinic in Rochester, Rochester, Minnesota, United States

Automated Abdominal Binder for Orthostatic Hypotension

Phase 1

Recruiting

Conditions: Multiple System Atrophy
Autonomic Failure
Orthostatic Hypotension
Pure Autonomic Failure

Interventions: Device: automated abdominal binder
Device: Sham binder
Drug: Placebo
Drug: Midodrine

First Posted Date: 2018-03-29

Last Posted Date: 2024-10-31

Lead Sponsor: Vanderbilt University Medical Center

Target Recruit Count: 31

Registration Number: NCT03482297

Locations: 🇺🇸
Autonomic Dysfunction Center/ Vanderbilt University Medical Center, Nashville, Tennessee, United States

Midodrine is Effective in Management of Intradialytic Hypotension Among Critically-ill Patients With Acute Kidney Injury

Not Applicable

Completed

Conditions: Acute Kidney Injury

Interventions: Drug: Placebo
Drug: midodrine

First Posted Date: 2018-02-13

Last Posted Date: 2022-08-22

Lead Sponsor: Benha University

Target Recruit Count: 80

Registration Number: NCT03431194

Efficacy and Safety of Midodrine and Atomoxetine for Neurogenic OH

Phase 4

Completed

Conditions: Neurogenic Orthostatic Hypotension

Interventions: Drug: Midodrine
Drug: Atomoxetine

First Posted Date: 2017-11-22

Last Posted Date: 2019-04-05

Lead Sponsor: Seoul National University Hospital

Target Recruit Count: 50

Registration Number: NCT03350659

Locations: 🇰🇷
Seoul National University Hospital, Seoul, Korea, Republic of

Efficacy and Safety of Terlipressin With Albumin Versus Midodrine With Albumin Versus Albumin Alone in Prevention of Paracentesis Induced Circulatory Dysfunction in Cirrhosis

Not Applicable

Completed

Conditions: Cirrhosis

Interventions: Drug: Albumin
Drug: Terlipressin
Drug: Midodrine

First Posted Date: 2017-05-09

Last Posted Date: 2018-09-05

Lead Sponsor: Institute of Liver and Biliary Sciences, India

Target Recruit Count: 150

Registration Number: NCT03144713

Locations: 🇮🇳
Institute of Liver and Biliary Sciences, New Delhi, Delhi, India

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