Midodrine
- Generic Name
- Midodrine
- Brand Names
- Proamatine
- Drug Type
- Small Molecule
- Chemical Formula
- C12H18N2O4
- CAS Number
- 42794-76-3
- Unique Ingredient Identifier
- 6YE7PBM15H
- Background
An ethanolamine derivative that is an adrenergic alpha agonist. It is used as a vasoconstrictor agent in the treatment of hypotension.
- Indication
For the treatment of symptomatic orthostatic hypotension (OH).
- Associated Conditions
- Symptomatic Orthostatic Hypotension
- Associated Therapies
- -
Treatment of Orthostatic Intolerance
Phase 1
Active, not recruiting
- Conditions
- TachycardiaChronic Orthostatic Intolerance
- Interventions
- Drug: Entacapone & PropranololDrug: AtomoxetineDrug: AcetazolamideDietary Supplement: MelatoninOther: NO DrugDrug: Isosorbide DinitrateRadiation: PlaceboDevice: Breathing DeviceOther: Drinking WaterProcedure: IV SalineDevice: Abdominal binderDrug: IndomethacinDrug: MidodrineDrug: MecamylamineDrug: ClonidineDrug: EntacaponeDrug: memantineDrug: ModafinilDrug: OctreotideDrug: SertralineDrug: Atomoxetine & PropranololDrug: Modafinil & PropranololDrug: Propranolol
- First Posted Date
- 2005-12-06
- Last Posted Date
- 2024-10-02
- Lead Sponsor
- Satish R. Raj
- Target Recruit Count
- 150
- Registration Number
- NCT00262470
- Locations
- 🇺🇸
Vanderbilt University Autonomic Dysfunction Center, Nashville, Tennessee, United States
Treatment of Orthostatic Hypotension in Autonomic Failure
Phase 1
Completed
- Conditions
- Autonomic FailureOrthostatic Hypotension
- Interventions
- Drug: AtomoxetineDrug: placeboDrug: AcarboseDevice: inflatable abdominal binder (sham)Drug: Pyridostigmine BromideDrug: YohimbineDrug: Midodrine HClDrug: ModafinilDrug: OctreotideOther: water intakeDrug: Diphenhydramine HydrochlorideDrug: Ranitidine HCLDrug: TranylcypromineDrug: Ergotamine/ CaffeineDrug: CelecoxibDrug: PseudoephedrineDrug: MethylphenidateDrug: IndomethacinDrug: IbuprofenDrug: Oxymetazoline 0.05% nasal solutionDietary Supplement: BovrilDrug: AcetazolamideDrug: Rivastigmine tartrateDrug: Carbidopa/levodopaDevice: Inflatable abdominal binder
- First Posted Date
- 2005-09-22
- Last Posted Date
- 2017-01-18
- Lead Sponsor
- Vanderbilt University
- Target Recruit Count
- 389
- Registration Number
- NCT00223691
- Locations
- 🇺🇸
Vanderbilt University, Nashville, Tennessee, United States
Vasoconstrictors as Alternatives to Albumin After Large-Volume Paracentesis (LVP) in Cirrhosis
Phase 4
Completed
- Conditions
- AscitesCirrhosis
- Interventions
- Drug: Intravenous Saline Infusion (Albumin placebo)Drug: AlbuminDrug: Oral tablet (Midodrine placebo)Drug: MidodrineDrug: Saline injection (Octreotide LAR placebo)Drug: Octreotide LARProcedure: Large Volume Paracentesis
- First Posted Date
- 2005-04-15
- Last Posted Date
- 2014-03-06
- Lead Sponsor
- US Department of Veterans Affairs
- Target Recruit Count
- 29
- Registration Number
- NCT00108355
- Locations
- 🇺🇸
VA Connecticut Health Care System (West Haven), West Haven, Connecticut, United States
Phase II Study of Midodrine for Neurogenic Orthostatic Hypotension
Phase 2
Completed
- Conditions
- Orthostatic Hypotension
- First Posted Date
- 1999-10-19
- Last Posted Date
- 2005-06-24
- Lead Sponsor
- National Center for Research Resources (NCRR)
- Target Recruit Count
- 300
- Registration Number
- NCT00004268
- Locations
- 🇺🇸
Mount Sinai School of Medicine, New York, New York, United States
Randomized Study of Midodrine, an Alpha Adrenergic Agonist, in Patients With Neurally Mediated Syncope
Not Applicable
Completed
- Conditions
- Syncope
- First Posted Date
- 1999-10-19
- Last Posted Date
- 2005-06-24
- Lead Sponsor
- Icahn School of Medicine at Mount Sinai
- Registration Number
- NCT00004479
- Locations
- 🇺🇸
Mount Sinai School of Medicine, New York, New York, United States
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