MedPath

Mebendazole

Generic Name
Mebendazole
Brand Names
Emverm, Vermox
Drug Type
Small Molecule
Chemical Formula
C16H13N3O3
CAS Number
31431-39-7
Unique Ingredient Identifier
81G6I5V05I
Background

A benzimidazole that acts by interfering with carbohydrate metabolism and inhibiting polymerization of microtubules. [PubChem]

Indication

For the treatment of Enterobius vermicularis (pinworm), Trichuris trichiura (whipworm), Ascaris lumbricoides (common roundworm), Ancylostoma duodenale (common hookworm), Necator americanus (American hookworm) in single or mixed infections.

Associated Conditions
Ancylostoma caninum infection, Ancylostoma duodenale infection, Ascaris lumbricoides infection, Capillariasis, Enterobius vermicularis infection, Filariasis, Giardiasis, Necatoriasis due to necator americanus, Strongyloides Stercoralis Infection, Taenia solium infection, Toxocariasis, Whipworm infection
Clinical Trials
Related News

Efficacy and Safety of Emodepside in Participants With Soil-transmitted Helminth Infections

Phase 3
Not yet recruiting
Conditions
Hookworm Infection
Trichuris Trichiura; Infection
Ascaris Lumbricoides Infection
Interventions
Drug: matching placebo of emodepside
Drug: similar placebo to mebendazole
First Posted Date
2025-01-29
Last Posted Date
2025-02-10
Lead Sponsor
Swiss Tropical & Public Health Institute
Target Recruit Count
315
Registration Number
NCT06800248
Locations
🇵🇭

University of the Philippines Manila, Manila, Philippines

Efficacy and Safety of Emodepside in Participants With Soil-transmitted Helminth Infections

Phase 3
Not yet recruiting
Conditions
Trichuris Trichiura; Infection
Hookworm Infection
Ascaris Lumbricoides Infection
Interventions
Drug: matching placebo of emodepside
Drug: similar placebo to mebendazole
First Posted Date
2024-12-17
Last Posted Date
2025-02-10
Lead Sponsor
Swiss Tropical & Public Health Institute
Target Recruit Count
315
Registration Number
NCT06736691
Locations
🇹🇿

Public Health Laboratory - Ivo de Carneri (PHL-IdC), Chake Chake, Tanzania

Efficacy and Safety of Oxantel Pamoate in Children Infected With Trichuris Trichiura

Phase 2
Active, not recruiting
Conditions
Trichuris Trichiura; Infection
Ascaris Lumbricoides Infection
Hookworm Infection
Interventions
First Posted Date
2024-12-06
Last Posted Date
2025-05-15
Lead Sponsor
Jennifer Keiser
Target Recruit Count
165
Registration Number
NCT06720259
Locations
🇹🇿

Public Health Laboratory Ivo de Carneri, Chake Chake, Tanzania

Possible Efficacy and Safety of Mebendazole in Patients With Ulcerative Colitis Treated With Mesalamine

Not Applicable
Not yet recruiting
Conditions
Ulcerative Colitis
Interventions
First Posted Date
2024-03-28
Last Posted Date
2024-03-28
Lead Sponsor
Tanta University
Target Recruit Count
46
Registration Number
NCT06335160

Nutrition Intervention to Address Anemia Among Adolescent Girls in Liberia

Not Applicable
Withdrawn
Conditions
Nutritional Deficiency
Iron Deficiency Anemia Treatment
Adolescent Development
Folic Acid Deficiency Anemia, Dietary
Knowledge, Attitudes, Practice
Nutritional Anemia
Food Habits
Interventions
Dietary Supplement: Iron and folic acid (IFA) supplementation
Other: Standard nutrition services
Behavioral: Targeted nutrition education
First Posted Date
2021-10-11
Last Posted Date
2021-11-22
Lead Sponsor
Boston Children's Hospital
Registration Number
NCT05073562

To Study the Effects of Addition of Mebendazole to Lenvatinib in Cirrhotics With Advanced Hepatocellular Carcinoma.

Not Applicable
Conditions
Hepatocellular Carcinoma
Liver Cirrhosis
Interventions
Other: Placebo
First Posted Date
2020-06-23
Last Posted Date
2021-10-05
Lead Sponsor
Institute of Liver and Biliary Sciences, India
Target Recruit Count
170
Registration Number
NCT04443049
Locations
🇮🇳

Institute of Liver & Biliary Sciences, New Delhi, Delhi, India

Efficacy and Safety of a New Chewable Versus the Swallowable Tablet of Mebendazole Against Hookworm

Phase 2
Completed
Conditions
Hookworm Infections
Interventions
First Posted Date
2019-06-24
Last Posted Date
2020-07-20
Lead Sponsor
Swiss Tropical & Public Health Institute
Target Recruit Count
397
Registration Number
NCT03995680
Locations
🇹🇿

Public Health Laboratory Ivo de Carneri, Chake Chake, Tanzania

Mebendazole as Adjuvant Treatment for Colon Cancer

Phase 3
Recruiting
Conditions
Colorectal Cancer
Interventions
First Posted Date
2019-04-24
Last Posted Date
2019-04-24
Lead Sponsor
Sherief Abd-Elsalam
Target Recruit Count
40
Registration Number
NCT03925662
Locations
🇪🇬

Sherief Abd-Elsalam, Cairo, Egypt

RDD1609 as a Treatment for Idiopathic Pruritus Ani

Phase 2
Withdrawn
Conditions
Idiopathic Pruritus Ani
Interventions
First Posted Date
2018-11-28
Last Posted Date
2022-11-03
Lead Sponsor
RDD Pharma Ltd
Registration Number
NCT03757403
Locations
🇬🇧

Sheepcot Medical Centre, Watford, United Kingdom

🇬🇧

University Hospitals Bristol NHS Foundation Trust- Location Bristol Royal Infirmary, Bristol, United Kingdom

🇬🇧

Kings Medical Centre, Buckhurst Hill, United Kingdom

and more 1 locations

Triple Combinations Against Hookworm Infections in Lao

Phase 4
Completed
Conditions
Hookworm Infection
Interventions
First Posted Date
2017-09-11
Last Posted Date
2018-05-08
Lead Sponsor
Swiss Tropical & Public Health Institute
Target Recruit Count
420
Registration Number
NCT03278431
Locations
🇱🇦

Nambak District Hospital, Luang Prabang, Lao People's Democratic Republic

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