MedPath

Mepivacaine

Generic Name
Mepivacaine
Brand Names
Carbocaine, Carbocaine With Neocobefrin, Isocaine, Isocaine With Levonordefrin, Polocaine, Scandonest, Scandonest L, Scandonest Plain
Drug Type
Small Molecule
Chemical Formula
C15H22N2O
CAS Number
96-88-8
Unique Ingredient Identifier
B6E06QE59J
Background

A local anesthetic that is chemically related to bupivacaine but pharmacologically related to lidocaine. It is indicated for infiltration, nerve block, and epidural anesthesia. Mepivacaine is effective topically only in large doses and therefore should not be used by this route. (From AMA Drug Evaluations, 1994, p168)

Indication

For production of local or regional analgesia and anesthesia by local infiltration, peripheral nerve block techniques, and central neural techniques including epidural and caudal blocks.

Associated Conditions
Anaemia vitamin B6 deficiency, Anemia, Blood Loss Anemia, Diabetic Peripheral Neuropathy (DPN)
Associated Therapies
Local Anaesthesia therapy, Regional nerve block therapy, Lumbar epidural anesthesia therapy
Clinical Trials
Related News

Spinal Anesthesia Versus Combined Sciatic-femoral Nerve Block for Outpatient Knee Arthroscopy

Phase 4
Completed
Conditions
Knee Arthritis
Interventions
Drug: prilocaine
Drug: mepivacaine
Procedure: Spinal anesthesia
Procedure: Sciatic-femoral Nerve Block
Device: Sonoplex, Pajunk
First Posted Date
2015-03-10
Last Posted Date
2015-05-08
Lead Sponsor
ASST Gaetano Pini-CTO
Target Recruit Count
100
Registration Number
NCT02384915
Locations
🇮🇹

Istituto Ortopedico G. Pini, Milan, Milano, Italy

Mepivacaine-Tramadol on the Success of Inferior Alveolar Nerve Block in Symptomatic Irreversible Pulpitis

Phase 4
Completed
Conditions
Symptomatic Irreversible Pulpitis
Interventions
Drug: Mepivacaine plus Tramadol
Drug: Mepivacaine
First Posted Date
2014-04-10
Last Posted Date
2014-10-31
Lead Sponsor
Daniel Chavarría Bolaños
Target Recruit Count
56
Registration Number
NCT02110966
Locations
🇲🇽

Endodontics Master Degree program, Dentistry Faculty, San Luis Potosi University, San Luis Potosi, Mexico

Analgesia for Insertion of Intrauterine Contraception

Phase 3
Completed
Conditions
Insertion of Intrauterine Contraception
Interventions
Drug: Placebo
Drug: Mepivacaine
First Posted Date
2014-03-05
Last Posted Date
2018-04-26
Lead Sponsor
Karolinska Institutet
Target Recruit Count
86
Registration Number
NCT02078063
Locations
🇸🇪

Dept of Obstetrics and Gynecology, Danderyd Hospital, Stockholm, Sweden

🇸🇪

Upplands Väsby Ungdomsmottagning, Stockholm, Sweden

Duration of Sciatic Nerve Block After Injection of Local Anesthetic In or Around the Nerve

Phase 4
Completed
Conditions
Orthopedic Surgical Procedures
Postoperative Pain
Interventions
Procedure: Perineural Injection for Subgluteal Sciatic Nerve Block
Procedure: Intraneural Injection for Subgluteal Sciatic Nerve Block
Procedure: Femoral Nerve Block
Procedure: Patient-controlled postoperative analgesia
Drug: Mepivacaine
First Posted Date
2013-11-11
Last Posted Date
2013-11-19
Lead Sponsor
University of Parma
Target Recruit Count
120
Registration Number
NCT01981291
Locations
🇮🇹

Anesthesia, Critical Care and Pain Medicine - University of Parma, Parma, PR, Italy

Treatment of Degenerative Disc Disease With Allogenic Mesenchymal Stem Cells (MSV)

Phase 1
Completed
Conditions
Low Back Pain
Intervertebral Disc Disease
Degenerative Disc Disease
Interventions
Biological: Allogenic Mesenchymal Stromal Cells
Drug: Mepivacaine
First Posted Date
2013-05-22
Last Posted Date
2024-04-29
Lead Sponsor
Red de Terapia Celular
Target Recruit Count
24
Registration Number
NCT01860417
Locations
🇪🇸

Hospital Clinico Universitario, Valladolid, Spain

🇪🇸

Instituto de Biologia y Genetica Molecular, Valladolid, Spain

Randomized Double Blind Controlled Trial Comparing a Blind Sciatic Nerve Block in the Popliteal Fossa to Intravenous Morphine for Traumatic Severe Acute Pain in the Prehospital Setting

Phase 3
Terminated
Conditions
Injuries
Pain
Emergencies
Interventions
Drug: Mepivacaine
Drug: Morphine
First Posted Date
2012-01-31
Last Posted Date
2019-11-20
Lead Sponsor
Centre Hospitalier Annecy Genevois
Target Recruit Count
26
Registration Number
NCT01522534
Locations
🇫🇷

Centre Hospitalier Sallanches Chamonix, Sallanches, France

🇫🇷

Centre Hospitalier Universitaire de GRENOBLE, Grenoble, France

🇫🇷

Centre Hospitalier d'Albertville moutiers, Albertville, France

and more 3 locations

Dosage of Mepivacaine in Ultrasound Axillary Block

Not Applicable
Completed
Conditions
Nerve Block
Neuromuscular Blockade
Anesthesia
Interventions
Drug: Mepivacaine
First Posted Date
2011-12-05
Last Posted Date
2011-12-08
Lead Sponsor
Wayne State University
Target Recruit Count
64
Registration Number
NCT01485653

Local Anesthetics New Formulations: From Development to Clinical Tests

Phase 1
Completed
Conditions
Local Anesthetic Effectiveness
First Posted Date
2009-12-16
Last Posted Date
2010-01-20
Lead Sponsor
University of Campinas, Brazil
Target Recruit Count
30
Registration Number
NCT01032798
Locations
🇧🇷

University of Campinas, Campinas, Sao Paulo, Brazil

Ultrasound Guided Supraclavicular Nerve Block

Phase 3
Completed
Conditions
Local Anesthetic
Interventions
Drug: Ropivacaine
Drug: Mepivacaine
First Posted Date
2009-01-21
Last Posted Date
2017-06-14
Lead Sponsor
The Cleveland Clinic
Target Recruit Count
103
Registration Number
NCT00825786
Locations
🇺🇸

Cleveland Clinic, Cleveland, Ohio, United States

Spinal Mepivicaine With Fentanyl for Outpatient Knee Arthroscopy

Not Applicable
Completed
Conditions
Knee Arthroscopy
Interventions
Drug: Mepivacaine without fentanyl
Drug: Mepivacaine with Fentanyl
First Posted Date
2008-12-05
Last Posted Date
2010-01-26
Lead Sponsor
University Health Network, Toronto
Target Recruit Count
34
Registration Number
NCT00803725
Locations
🇨🇦

Toronto Western Hospital, Toronto, Ontario, Canada

© Copyright 2025. All Rights Reserved by MedPath
HomeTerms & ConditionsPrivacy Policy