Cyclosporine

Generic Name
Cyclosporine
Brand Names
Cequa, Gengraf, Neoral, Restasis, Sandimmune, Verkazia, Vevye, Ikervis
Drug Type
Small Molecule
Chemical Formula
C62H111N11O12
CAS Number
59865-13-3
Unique Ingredient Identifier
83HN0GTJ6D
Background

Cyclosporine is a calcineurin inhibitor known for its immunomodulatory properties that prevent organ transplant rejection and treat various inflammatory and autoimmune conditions. It is isolated from the fungus Beauveria nivea. Initially manufactured by Sandoz and approved for use by the FDA in 1983, cyclosporine is now available in various products by Novar...

Indication

Cyclosporine is approved for a variety of conditions. Firstly, it is approved for the prophylaxis of organ rejection in allogeneic kidney, liver, and heart transplants. It is also used to prevent bone marrow transplant rejection. For the above indications, cyclosporine can be used in conjunction with azathioprine and corticosteroids. Finally, cyclosporine ca...

Associated Conditions
Atopic Dermatitis, Bone Marrow Transplant Rejection, Chronic transplant rejection, Connective Tissue Disorders, Dry Eyes, Graft-versus-host Disease (GVHD), Heart Transplant Rejection, Immune Thrombocytopenia (ITP), Interstitial Cystitis, Juvenile Idiopathic Arthritis (JIA), Kidney Transplant Rejection, Liver Transplant Rejection, Lupus Nephritis, Nephrotic Syndrome, Ocular Rosacea, Rheumatoid Arthritis, Severe Ulcerative Colitis, Steroid Dependent Nephrotic Syndrome, Steroid Resistant Nephrotic Syndrome, Uveitis, Vernal Keratoconjunctivitis, Blistering disorder, Refractory Ulcerative colitis, Severe Psoriasis, Severe, active Rheumatoid arthritis, Severe, recalcitrant Plaque psoriasis, Suppressed tear production
Associated Therapies
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Clinical Trials
Related News

Clinical Study Evaluating Two Treatment Protocols for Immunosuppressive Drugs. Looking at 3-year Incidence of CLAD.

First Posted Date
2016-10-18
Last Posted Date
2023-04-26
Lead Sponsor
Vastra Gotaland Region
Target Recruit Count
249
Registration Number
NCT02936505
Locations
🇳🇴

Oslo University Hospital, Oslo, Norway

🇩🇰

Rigshospitalet, Copenhagen, Denmark

🇸🇪

Skåne University Hospital, Lund, Sweden

and more 2 locations

Efficacy and Safety Study of HU00701/HU007 Eye Drops in Patients With Dry Eye Syndrome

First Posted Date
2016-09-28
Last Posted Date
2018-04-12
Lead Sponsor
Huons Co., Ltd.
Target Recruit Count
114
Registration Number
NCT02917512
Locations
🇰🇷

Huons, Seongnam-si, Gyeonggi-do, Korea, Republic of

Abatacept for GVHD Prophylaxis After Hematopoietic Stem Cell Transplantation for Pediatric Sickle Cell Disease

First Posted Date
2016-08-16
Last Posted Date
2024-06-13
Lead Sponsor
Monica Bhatia
Target Recruit Count
24
Registration Number
NCT02867800
Locations
🇺🇸

North Carolina Cancer Hospital, Chapel Hill, North Carolina, United States

🇺🇸

Columbia University Irving Medical Center, New York, New York, United States

🇺🇸

Children's National Medical Center, Washington, District of Columbia, United States

and more 4 locations

SCHEDULE Follow Up Visit 5-7 yr

First Posted Date
2016-08-12
Last Posted Date
2019-10-03
Lead Sponsor
Novartis Pharmaceuticals
Target Recruit Count
95
Registration Number
NCT02864706
Locations
🇸🇪

Novartis Investigative Site, Lund, Sweden

Unrelated Donor Transplant Versus Immune Therapy in Pediatric Severe Aplastic Anemia

First Posted Date
2016-07-27
Last Posted Date
2023-10-26
Lead Sponsor
Michael Pulsipher, MD
Target Recruit Count
40
Registration Number
NCT02845596
Locations
🇺🇸

Children's Hospital Los Angeles, Los Angeles, California, United States

🇺🇸

Fred Hutchinson Cancer Research Center, Seattle, Washington, United States

🇺🇸

Hackensack University Medical Center, Hackensack, New Jersey, United States

and more 10 locations

ATG Combined With Cyclophosphamide And Cord Blood Transfusion in Treating Patients With Severe Aplastic Anemia

First Posted Date
2016-07-20
Last Posted Date
2017-02-01
Lead Sponsor
Jinan Military General Hospital
Target Recruit Count
130
Registration Number
NCT02838992
Locations
🇨🇳

The General Hospital Of Jinan Military Command, Jinan, Shandong, China

Early Allogeneic Hematopoietic Cell Transplantation in Treating Patients With Relapsed or Refractory High-Grade Myeloid Neoplasms

First Posted Date
2016-04-29
Last Posted Date
2021-11-08
Lead Sponsor
University of Washington
Target Recruit Count
30
Registration Number
NCT02756572
Locations
🇺🇸

Fred Hutch/University of Washington Cancer Consortium, Seattle, Washington, United States

Use of Cyclosporin A for the Treatment of Recurrent Miscarriage

First Posted Date
2016-03-11
Last Posted Date
2016-03-15
Lead Sponsor
Fudan University
Target Recruit Count
384
Registration Number
NCT02706470
Locations
🇨🇳

Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China

Phase 3 Study of OTX-101 in the Treatment of Keratoconjunctivitis Sicca

First Posted Date
2016-02-23
Last Posted Date
2022-08-29
Lead Sponsor
Sun Pharmaceutical Industries Limited
Target Recruit Count
745
Registration Number
NCT02688556
Locations
🇺🇸

Martel Eye Medical Group, Rancho Cordova, California, United States

🇺🇸

Fifth Avenue Eye Associates, New York, New York, United States

🇺🇸

Cincinnati Eye Institute, Edgewood, Kentucky, United States

Study Comparing Efficacy and Safety of Mycophenolate Mofetil (Cellcept) With Delayed Introduction of Sirolimus and Discontinuation of Cyclosporine, With Those of Mycophenolate Mofetil and Long Term Continuation of Cyclosporine in Renal Transplant Recipients

First Posted Date
2016-02-19
Last Posted Date
2016-02-19
Lead Sponsor
Hoffmann-La Roche
Target Recruit Count
237
Registration Number
NCT02686619
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