Clonidine

Generic Name: Clonidine

Brand Names: Catapres, Catapres-TTS, Catapres-tts-1, Duraclon, Kapvay, Nexiclon XR

Drug Type: Small Molecule

Chemical Formula: C_₉H_₉Cl_₂N_₃

CAS Number: 4205-90-7

Unique Ingredient Identifier: MN3L5RMN02

Background: Clonidine is an imidazole derivate that acts as an agonist of alpha-2 adrenoceptors. This activity is useful for the treatment of hypertension, severe pain, and ADHD.

Clonidine was granted FDA approval on 3 September 1974.

Indication: Clonidine tablets and transdermal systems are indicated for the treatment of hypertension alone or in combination with other medications. A clonidine injection is indicated for use with opiates in the treatment of severe cancer pain where opiates alone are insufficient. An extended release tablet of clonidine is indicated for the treatment of ADHD either alo...

Associated Conditions: Attention Deficit Hyperactivity Disorder (ADHD), Defiant Disorder, Oppositional, Gilles de la Tourette's Syndrome, Hot Flashes, Human Growth Hormone Deficiency, Hypertension, Opioid Withdrawal (Disorder), Pheochromocytoma, Postherpetic Neuralgia, Sialorrhea caused by clozapine, Diabetic diarrhea, Methadone withdrawal, Severe Cancer pain

Associated Therapies: Smoking, Cessation

Clinical Trials

Pilot Study: Intraoperative Clonidine and Postoperative Behaviour

Phase 3

Completed

Conditions: Negative Behaviour Change

Interventions: Drug: Placebo
Drug: Clonidine

First Posted Date: 2014-12-24

Last Posted Date: 2014-12-24

Lead Sponsor: Richard Beringer

Target Recruit Count: 45

Registration Number: NCT02324413

Locations: 🇬🇧
Bristol Dental Hospital, Bristol, United Kingdom

Treatment of Chronic Itch in Atopic Dermatitis (Eczema): Nerve Function

Phase 1

Completed

Conditions: Cutaneous Nerves CNS Itch

Interventions: Drug: Clonidine
Drug: Naltrexone

First Posted Date: 2014-10-20

Last Posted Date: 2023-01-26

Lead Sponsor: University of Minnesota

Target Recruit Count: 8

Registration Number: NCT02268448

Locations: 🇺🇸
University of Minnesota Department of Dermatology, Minneapolis, Minnesota, United States

Epidural Clonidine Versus Corticosteroid for Low Back Pain

Not Applicable

Terminated

Conditions: Back Pain

Interventions: Drug: Clonidine
Drug: Epidural steroid

First Posted Date: 2014-09-15

Last Posted Date: 2021-01-20

Lead Sponsor: West Virginia University

Target Recruit Count: 16

Registration Number: NCT02239627

Locations: 🇺🇸
West Virginia University Hospitals, Morgantown, West Virginia, United States

Use of Intraoperative Clonidine for Prevention of Postoperative Agitation in Pedriatic Anesthesia With Sevoflurane.

Phase 3

Completed

Conditions: Is an Only Child

Interventions: Drug: Clonidine

First Posted Date: 2014-07-04

Last Posted Date: 2017-10-04

Lead Sponsor: Professor Fernando Figueira Integral Medicine Institute

Target Recruit Count: 30

Registration Number: NCT02181543

Locations: 🇧🇷
Instituto de Medicina Integral Prof. Fernando Figueira (IMIP), Recife, Pernambuco, Brazil

Telmisartan Compared With Enalapril in Elderly Patients With Blood Hypertension

Phase 4

Completed

Conditions: Hypertension

Interventions: Drug: Telmisartan
Drug: Enalapril
Drug: Clonidine

First Posted Date: 2014-06-27

Last Posted Date: 2014-07-08

Lead Sponsor: Boehringer Ingelheim

Target Recruit Count: 374

Registration Number: NCT02177461

Bioequivalence of Two Transdermal Clonidine Administrations in Healthy Volunteers

Phase 1

Completed

Conditions: Healthy

Interventions: Drug: Catapres-TTS-1

First Posted Date: 2014-03-26

Last Posted Date: 2015-07-16

Lead Sponsor: Boehringer Ingelheim

Target Recruit Count: 56

Registration Number: NCT02096744

Locations: 🇺🇸
253.2486.1 Boehringer Ingelheim Investigational Site, Austin, Texas, United States

Effectiveness of Perineural Clonidine as an Adjuvant With Ropivacaine for Popliteal Nerve Block in Patients Undergoing Foot and Ankle Surgery

Phase 1

Terminated

Conditions: Pain

Interventions: Drug: Clonidine
Drug: ropivacaine

First Posted Date: 2013-11-18

Last Posted Date: 2016-11-04

Lead Sponsor: University of Alabama at Birmingham

Target Recruit Count: 14

Registration Number: NCT01986751

Locations: 🇺🇸
University of Alabama at Birmingham, Birmingham, Alabama, United States

Vascular Dysfunction in Human Obesity Hypertension

Phase 2

Terminated

Conditions: Obesity
Prehypertension
Hypertension

Interventions: Drug: Placebo
Drug: Clonidine
Drug: Hydrochlorothiazide

First Posted Date: 2013-11-14

Last Posted Date: 2023-04-14

Lead Sponsor: Gary L. Pierce

Target Recruit Count: 33

Registration Number: NCT01983462

Locations: 🇺🇸
University of Iowa, Iowa City, Iowa, United States

The Oslo Study of Clonidine in Elderly Patients With Delirium

Phase 2

Terminated

Conditions: Delirium

Interventions: Drug: Placebo
Drug: Clonidine

First Posted Date: 2013-10-08

Last Posted Date: 2018-10-31

Lead Sponsor: Oslo University Hospital

Target Recruit Count: 20

Registration Number: NCT01956604

Locations: 🇳🇴
Oslo University Hospital, Oslo, Norway

Added Value of Local Clonidine for Spine Postoperative Pain Control, in Addition to Bupivacaine

Phase 4

Completed

Conditions: Post-operative Pain

Interventions: Drug: Clonidine
Drug: Bupivacaine

First Posted Date: 2013-07-18

Last Posted Date: 2015-12-08

Lead Sponsor: St Joseph University, Beirut, Lebanon

Target Recruit Count: 225

Registration Number: NCT01902108

Locations: 🇱🇧
Hotel Dieu de france Hospital, Beirut, Lebanon

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