Amitriptyline

Generic Name: Amitriptyline

Brand Names: Elavil

Drug Type: Small Molecule

Chemical Formula: C_₂₀H_₂₃N

CAS Number: 50-48-6

Unique Ingredient Identifier: 1806D8D52K

Background: Amitriptyline is a tricyclic antidepressant that has been used to treat depression for decades. ELAVIL, a previously approved branded product of amitriptyline, was first approved by the FDA in 1961. Amitriptyline has been investigated in the treatment of pain-related conditions, attributed to its analgesic properties.

Indication: This drug in indicated for the following conditions :

Major depressive disorder in adults

Management of neuropathic pain in adults

Prophylactic treatment of chronic tension-type headache (CTTH) in adults

Prophylactic treatment of migraine in adults
...

Associated Conditions: Anorexia Nervosa (AN), Attention Deficit Hyperactivity Disorder (ADHD), Bulimia Nervosa, Depression, Depression Acute, Diabetic Neuropathies, Insomnia, Irritable Bowel Syndrome (IBS), Major Depressive Disorder (MDD), Migraine, Moderate Depression, Neuropathic Pain, Nocturnal Enuresis, Severe Depression, Sleep disorders and disturbances, Tension Headache, Moderate Agitation, Moderate Anxiety, Severe Anxiety, Severe agitation

Associated Therapies: -

Clinical Trials

The Childhood and Adolescent Migraine Prevention Study

Phase 3

Terminated

Conditions: Migraine
Migraine Disorders
Headache

Interventions: Drug: Amitriptyline
Drug: Topiramate
Drug: Placebo

First Posted Date: 2012-04-20

Last Posted Date: 2017-08-10

Lead Sponsor: Children's Hospital Medical Center, Cincinnati

Target Recruit Count: 488

Registration Number: NCT01581281

Locations: 🇺🇸
University of Maryland School of Medicine, Baltimore, Maryland, United States
🇺🇸
University of Nevada, Reno, Nevada, United States
🇺🇸
Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States

and more 32 locations

The Influence of Amitriptyline on Learning in a Visual Discrimination Task

Not Applicable

Completed

Conditions: Healthy Subjects

Interventions: Drug: Amitriptyline
Drug: Placebo

First Posted Date: 2012-03-29

Last Posted Date: 2012-03-29

Lead Sponsor: Dieter Kunz, MD

Target Recruit Count: 32

Registration Number: NCT01566825

Locations: 🇩🇪
Charité - Universitätsmedizin Berlin, Department of Physiology CBF, Berlin, Germany

Study With Amitriptylin to Evaluate the Efficacy of Melatonin in Treatment of Migraine

Phase 3

Completed

Conditions: Migraine

Interventions: Drug: Placebo
Drug: Amitriptyline
Drug: Melatonin

First Posted Date: 2011-05-20

Last Posted Date: 2015-12-30

Lead Sponsor: Hospital Israelita Albert Einstein

Target Recruit Count: 192

Registration Number: NCT01357031

Locations: 🇧🇷
Instituto Israelita de Ensino e Pesquisa Albert Einstein, São Paulo, Brazil

Anti-inflammatory Pulmonal Therapy of Cystic Fibrosis (CF) Patients With Amitriptyline and Placebo

Phase 2

Conditions: Cystic Fibrosis
Pneumonia

Interventions: Drug: Mannite
Drug: Amitriptyline

First Posted Date: 2011-03-07

Last Posted Date: 2011-03-07

Lead Sponsor: University Children's Hospital Tuebingen

Target Recruit Count: 30

Registration Number: NCT01309178

Locations: 🇩🇪
Lutz Naehrlich, Giessen, Germany
🇩🇪
Joachim Riethmueller, Tuebingen, Germany
🇩🇪
Jochen Mainz, Jena, Germany

Amitriptyline Regarding Nimesulide in Acute Idiopathic Adhesive Capsulitis

Phase 2

Completed

Conditions: Adhesive Capsulitis

Interventions: Drug: amitriptyline

First Posted Date: 2011-03-02

Last Posted Date: 2012-01-31

Lead Sponsor: Universidade do Sul de Santa Catarina

Target Recruit Count: 34

Registration Number: NCT01306708

Locations: 🇧🇷
Universidade do Sul de Santa Catarina, Tubarão, Santa Catarina, Brazil

Trial of Amitriptyline for Chronic Oral Food Refusal in Children 9 Months to 8 Years of Age

Phase 2

Completed

Conditions: Chronic Oral Food Refusal

Interventions: Drug: Placebo
Drug: Amitriptyline
Drug: Megestrol

First Posted Date: 2010-09-21

Last Posted Date: 2016-08-15

Lead Sponsor: Ann Davis, PhD, MPH, ABPP

Target Recruit Count: 21

Registration Number: NCT01206478

Locations: 🇺🇸
Children's Hospital of New Orleans, New Orleans, Louisiana, United States
🇺🇸
Nationwide Children's Hospital, Columbus, Ohio, United States
🇺🇸
University of Kansas Medical Center, Kansas City, Kansas, United States