Ivabradine
- Generic Name
- Ivabradine
- Brand Names
- Corlanor, Lancora, Procoralan, Corlentor, Ivabradine Accord, Ivabradine Anpharm, Ivabradine Zentiva
- Drug Type
- Small Molecule
- Chemical Formula
- C27H36N2O5
- CAS Number
- 155974-00-8
- Unique Ingredient Identifier
- 3H48L0LPZQ
- Background
Ivabradine is a novel heart rate lowering medicine for the symptomatic management of stable angina pectoralis and symptomatic chronic heart failure. Ivabradine, brand name Corlanor, was approved by the FDA in April 2015 for the treatment of chronic heart failure in patients with an ejection fraction of ≤35%, in sinus rhythm with resting heart rate ≥70 beats ...
- Indication
Ivabradine is indicated by the FDA to reduce the risk of hospitalization for worsening heart failure in adult patients with stable, symptomatic chronic heart failure with left ventricular ejection fraction ≤35%, who are in sinus rhythm with resting heart rate ≥70 beats per minute and either are on maximally tolerated doses of beta-blockers or have a contrain...
- Associated Conditions
- Chronic Heart Failure (CHF), Chronic Stable Angina Pectoris, Left Ventricular Dysfunction, Chronic, stable, symptomatic Heart Failure
- Associated Therapies
- -
Effect of Ivabradine on Levcromakalim-Induced Symptoms in Individuals With Migraine Without Aura (ILIM)
- Conditions
- Interventions
- First Posted Date
- 2021-04-21
- Last Posted Date
- 2024-03-25
- Lead Sponsor
- Danish Headache Center
- Target Recruit Count
- 30
- Registration Number
- NCT04853797
- Locations
- 🇩🇰
Danish Headache Centre, Rigshospitalet-Glostrup, Glostrup, Zealand, Denmark
🇩🇰Danish Headache Center, Glostrup, Denmark
PeRiOperaTivE CardioproTection With Ivabradine in Non-cardiac Surgery
- Conditions
- Interventions
- First Posted Date
- 2020-06-17
- Last Posted Date
- 2022-03-02
- Lead Sponsor
- University Hospital, Geneva
- Target Recruit Count
- 78
- Registration Number
- NCT04436016
- Locations
- 🇨🇭
Geneva University Hospitals, Geneva, Switzerland
Efficacy of Oral Ivabradine in Patients Presenting With NSTEMI
- First Posted Date
- 2020-02-26
- Last Posted Date
- 2024-08-22
- Lead Sponsor
- Cairo University
- Target Recruit Count
- 100
- Registration Number
- NCT04285736
Efficacy of Ivabradine Versus Propranolol Premedication During Hypotensive Anesthesia in Endoscopic Sinus Surgery
- Conditions
- Interventions
- First Posted Date
- 2019-12-23
- Last Posted Date
- 2019-12-23
- Lead Sponsor
- Alexandria University
- Target Recruit Count
- 50
- Registration Number
- NCT04208594
- Locations
- 🇪🇬
Alexandria university, Alexandria, Egypt
Ivabradine for Heart Rate Control In Septic Shock
- First Posted Date
- 2019-07-24
- Last Posted Date
- 2024-06-25
- Lead Sponsor
- Assistance Publique - Hôpitaux de Paris
- Target Recruit Count
- 429
- Registration Number
- NCT04031573
- Locations
- 🇫🇷
Henri Mondor Hospital, Créteil, France
Ivabradine to Prevent Anthracycline-induced Cardiotoxicity
- First Posted Date
- 2019-07-24
- Last Posted Date
- 2019-12-18
- Lead Sponsor
- Vilnius University
- Target Recruit Count
- 128
- Registration Number
- NCT04030546
- Locations
- 🇱🇹
Vilnius University Hospital Santaros klinikos, Vilnius, Lithuania
Ivabradine for Rate Control in Permanent Atrial Fibrillation
- Conditions
- Interventions
- First Posted Date
- 2019-06-14
- Last Posted Date
- 2021-07-02
- Lead Sponsor
- Yale University
- Target Recruit Count
- 4
- Registration Number
- NCT03987204
- Locations
- 🇺🇸
Yale New Haven Hospital, New Haven, Connecticut, United States
Effects of Ivabradine on Residual Myocardial Ischemia After PCI
- First Posted Date
- 2019-03-07
- Last Posted Date
- 2019-03-07
- Lead Sponsor
- Azienda Policlinico Umberto I
- Target Recruit Count
- 28
- Registration Number
- NCT03866395
- Locations
- 🇮🇹
Massimo Mancone, Rome, Italy
Efficacy and Safety of Ivabradine to Reduce Heart Rate Prior to Coronary CT-angiography in Advanced Heart Failure: Comparison With β-Blocker
- First Posted Date
- 2019-02-05
- Last Posted Date
- 2019-04-12
- Target Recruit Count
- 200
- Registration Number
- NCT03830957
- Locations
- 🇮🇷
Ahmad Amin, Tehran, Iran, Islamic Republic of
IvaBRAdine blocK of Funny Current for Heart Rate Control in permanEnt Atrial Fibrillation. (BRAKE-AF Study).
- Conditions
- Interventions
- First Posted Date
- 2018-10-24
- Last Posted Date
- 2022-10-07
- Lead Sponsor
- Adolfo Fontenla
- Target Recruit Count
- 68
- Registration Number
- NCT03718273
- Locations
- 🇪🇸
Hospital Universitario Puerta de Hierro, Madrid, Spain
🇪🇸Hospital Universitario de Burgos, Burgos, Spain
🇪🇸Hospital Clínico San Carlos, Madrid, Spain
Drug Development Updates
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