Ivabradine
- Generic Name
- Ivabradine
- Brand Names
- Corlanor, Lancora, Procoralan, Corlentor, Ivabradine Accord, Ivabradine Anpharm, Ivabradine Zentiva
- Drug Type
- Small Molecule
- Chemical Formula
- C27H36N2O5
- CAS Number
- 155974-00-8
- Unique Ingredient Identifier
- 3H48L0LPZQ
- Background
Ivabradine is a novel heart rate lowering medicine for the symptomatic management of stable angina pectoralis and symptomatic chronic heart failure. Ivabradine, brand name Corlanor, was approved by the FDA in April 2015 for the treatment of chronic heart failure in patients with an ejection fraction of ≤35%, in sinus rhythm with resting heart rate ≥70 beats ...
- Indication
Ivabradine is indicated by the FDA to reduce the risk of hospitalization for worsening heart failure in adult patients with stable, symptomatic chronic heart failure with left ventricular ejection fraction ≤35%, who are in sinus rhythm with resting heart rate ≥70 beats per minute and either are on maximally tolerated doses of beta-blockers or have a contrain...
- Associated Conditions
- Chronic Heart Failure (CHF), Chronic Stable Angina Pectoris, Left Ventricular Dysfunction, Chronic, stable, symptomatic Heart Failure
- Associated Therapies
- -
Effects of Ivabradine on Cardiovascular Events in Patients With Moderate to Severe Chronic Heart Failure and Left Ventricular Systolic Dysfunction. A Three-year International Multicentre Study
- First Posted Date
- 2015-05-12
- Last Posted Date
- 2020-01-03
- Lead Sponsor
- Institut de Recherches Internationales Servier
- Target Recruit Count
- 6505
- Registration Number
- NCT02441218
- Locations
- 🇸🇪
Göteborg University, Göteborg, Sweden
🇫🇷Hôpital Pitié-Salpétrière, Paris, France
The Role of Chronotropic Incompetence in Heart Failure With Normal Ejection Fraction (HFNEF)
- First Posted Date
- 2015-02-03
- Last Posted Date
- 2015-02-04
- Lead Sponsor
- University of Oxford
- Target Recruit Count
- 121
- Registration Number
- NCT02354573
- Locations
- 🇬🇧
Univesrtity of Oxford, John Radcliffe Hospital, Oxford, United Kingdom
Therapeutic Approach to Diastolic Dysfunction in Chronic Liver Disease Patients and Its Impact on Morbidity and Mortality
- Conditions
- Interventions
- First Posted Date
- 2014-11-19
- Last Posted Date
- 2018-02-08
- Lead Sponsor
- Institute of Liver and Biliary Sciences, India
- Target Recruit Count
- 189
- Registration Number
- NCT02294292
- Locations
- 🇮🇳
Institute of Liver & Biliary Sciences, New Delhi, Delhi, India
The Influence of Heart Rate Limitation on Exercise Tolerance in Pacemaker Patients.
- Conditions
- Interventions
- First Posted Date
- 2014-09-23
- Last Posted Date
- 2020-01-02
- Lead Sponsor
- University of Leeds
- Target Recruit Count
- 40
- Registration Number
- NCT02247245
- Locations
- 🇬🇧
Leeds Institute of Cardiovascular and Metabolic Medicine, Leeds, West Yorkshire, United Kingdom
Control of Sinus Node Tachycardia as an Additional Therapy in Patients With Decompensated Heart Failure
- First Posted Date
- 2014-09-10
- Last Posted Date
- 2017-01-02
- Lead Sponsor
- University of Sao Paulo
- Target Recruit Count
- 50
- Registration Number
- NCT02236247
- Locations
- 🇧🇷
Heart Failure Unit, Heart Institute, University of Sao Paulo Medical School, Sao Paulo, Brazil
Ivabradine in Patients With an Unsatisfactory Percentage of Cardiac Resynchronization Therapy
- First Posted Date
- 2014-06-18
- Last Posted Date
- 2014-06-18
- Lead Sponsor
- Medical University of Warsaw
- Target Recruit Count
- 60
- Registration Number
- NCT02166060
- Locations
- 🇵🇱
1st Department of Cariology of Medcial University of Warsaw, Warsaw, Mazowieckie, Poland
Iatrogenic Chronotropic Incompetence and Exercise Tolerance in Heart Failure
- Conditions
- Interventions
- First Posted Date
- 2014-03-13
- Last Posted Date
- 2016-02-26
- Lead Sponsor
- The Leeds Teaching Hospitals NHS Trust
- Registration Number
- NCT02086422
- Locations
- 🇬🇧
Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom
Digoxin Versus Ivabradine in Heart Failure With Reduced Ejection Fraction
- First Posted Date
- 2014-01-27
- Last Posted Date
- 2014-01-27
- Lead Sponsor
- Kocaeli University
- Target Recruit Count
- 60
- Registration Number
- NCT02046044
- Locations
- 🇹🇷
Kocaeli University, Kocaeli, Turkey
Study to Investigate the Effect of Heart Rate Reduction With Ivabradine on Vascular Elastic Properties and Endothelial Function in Patients With Stable Coronary Heart Disease
- Conditions
- Interventions
- First Posted Date
- 2013-01-15
- Last Posted Date
- 2013-01-15
- Lead Sponsor
- University Hospital, Saarland
- Target Recruit Count
- 50
- Registration Number
- NCT01768585
- Locations
- 🇩🇪
University Hospital, Saarland, Homburg, Saarland, Germany
The Effect of Ivabradine on Patients With Postural Tachycardia Syndrome
- First Posted Date
- 2013-01-07
- Last Posted Date
- 2013-01-07
- Lead Sponsor
- Tel-Aviv Sourasky Medical Center
- Target Recruit Count
- 20
- Registration Number
- NCT01761825
Drug Development Updates
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