Alteplase
- Generic Name
- Alteplase
- Brand Names
- Activase, Cathflo, Cathflo Activase
- Drug Type
- Biotech
- Chemical Formula
- -
- CAS Number
- 105857-23-6
- Unique Ingredient Identifier
- 1RXS4UE564
- Background
Alteplase is a recombinant tissue plasminogen activator (rt-PA) used as a thrombolytic agent. It cleaves plasminogen to form plasmin, an enzyme involved in the degradation of fibrin clots. In the absence of fibrin, the alteplase-mediated conversion of plasminogen is limited, thanks to the high affinity between alteplase and fibrin. Alteplase is a purified gl...
- Indication
Alteplase is indicated for the treatment of acute ischemic stroke (AIS) and for use in acute myocardial infarction (AMI) for the reduction of mortality and incidence of heart failure. Alteplase is also indicated for the lysis of acute massive pulmonary embolism, defined as acute pulmonary emboli obstructing blood flow to a lobe or multiple lung segments, and...
- Associated Conditions
- Acute Ischemic Stroke, Cardiac mortality, Heart Failure, Pulmonary Embolism Acute Massive, Central venous access device thrombosis
- Associated Therapies
- -
Dose-effect Relationship of Rt-PA on ICH Evacuation
- Conditions
- Interventions
- First Posted Date
- 2015-06-16
- Last Posted Date
- 2015-06-16
- Lead Sponsor
- Tongji Hospital
- Target Recruit Count
- 108
- Registration Number
- NCT02472574
- Locations
- 🇨🇳
Tongji Hospital, Wuhan, Hubei, China
Helping Stroke Patients With ThermoSuit Cooling
- Conditions
- Interventions
- First Posted Date
- 2015-05-25
- Last Posted Date
- 2023-06-06
- Lead Sponsor
- Life Recovery Systems
- Target Recruit Count
- 14
- Registration Number
- NCT02453373
- Locations
- 🇺🇸
Geisinger Medical Center, Danville, Pennsylvania, United States
🇺🇸U of SC School of Medicine, Columbia, South Carolina, United States
🇺🇸Tulane University, New Orleans, Louisiana, United States
Quality of Life After Stroke Using a Telemedicine-based Stroke Network
- Conditions
- Interventions
- First Posted Date
- 2015-05-18
- Last Posted Date
- 2016-02-09
- Lead Sponsor
- Thomas Jefferson University
- Target Recruit Count
- 300
- Registration Number
- NCT02447094
- Locations
- 🇺🇸
Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, United States
Tenecteplase Versus Alteplase Before Endovascular Therapy for Ischemic Stroke
- Conditions
- Interventions
- First Posted Date
- 2015-03-13
- Last Posted Date
- 2018-03-30
- Lead Sponsor
- Neuroscience Trials Australia
- Target Recruit Count
- 202
- Registration Number
- NCT02388061
- Locations
- 🇦🇺
Royal Prince Alfred Hospital, Camperdown, New South Wales, Australia
🇦🇺Gosford Hospital, Gosford, New South Wales, Australia
🇦🇺John Hunter Hospital, Newcastle, New South Wales, Australia
Superiority of Rt-PA + Tenecteplase in Comparison With Rt-PA Only in Proximal Middle Cerebral Artery Occlusion
- Conditions
- Interventions
- First Posted Date
- 2015-01-14
- Last Posted Date
- 2018-06-21
- Lead Sponsor
- University Hospital Center of Martinique
- Registration Number
- NCT02338466
Perfusion Computer Tomography: Imaging and Clinical Validation Following Reperfusion Therapy in Acute Ischaemic Stroke
- First Posted Date
- 2014-12-05
- Last Posted Date
- 2014-12-05
- Lead Sponsor
- Rabin Medical Center
- Target Recruit Count
- 90
- Registration Number
- NCT02309970
- Locations
- 🇮🇱
Rabin Medical Center, Petach Tiqva, Hamerkaz, Israel
A Trial of Low-dose Adjunctive alTeplase During prIMary PCI
- First Posted Date
- 2014-10-06
- Last Posted Date
- 2019-09-06
- Lead Sponsor
- NHS Greater Glasgow and Clyde
- Target Recruit Count
- 440
- Registration Number
- NCT02257294
- Locations
- 🇬🇧
Glenfield Hospital, Leicester, United Kingdom
🇬🇧Edinburgh Royal Infirmary, Edinburgh, United Kingdom
🇬🇧Golden Jubilee National Hospital, Glasgow, United Kingdom
An International Observational Study of the Safety and Efficacy of Thrombolysis in Stroke
- First Posted Date
- 2014-09-03
- Last Posted Date
- 2014-09-03
- Lead Sponsor
- Boehringer Ingelheim
- Target Recruit Count
- 593
- Registration Number
- NCT02229890
Protocol for Post Marketing Surveillance of Actilyse Vial
- First Posted Date
- 2014-09-01
- Last Posted Date
- 2014-09-01
- Lead Sponsor
- Boehringer Ingelheim
- Target Recruit Count
- 265
- Registration Number
- NCT02229799
Safe Implementation of Thrombolysis in Stroke - Monitoring Study
- First Posted Date
- 2014-09-01
- Last Posted Date
- 2014-09-01
- Lead Sponsor
- Boehringer Ingelheim
- Target Recruit Count
- 6475
- Registration Number
- NCT02229812
Drug Development Updates
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