Doripenem
- Generic Name
- Doripenem
- Brand Names
- -
- Drug Type
- Small Molecule
- Chemical Formula
- C15H24N4O6S2
- CAS Number
- 148016-81-3
- Unique Ingredient Identifier
- BHV525JOBH
- Background
Doripenem is a broad-spectrum, carbapenem antibiotic marketed under the brand name Doribax by Janssen. Doripenem injection was approved by the FDA in 2007 to treat complicated urinary tract and intra-abdominal infections. In a clinical trial of doripenem treatment in ventilator associated pneumonia (vs. imipenem and cilastatin), it was found that doripenem c...
- Indication
用于敏感的革兰阳性菌、阴性菌和厌氧菌所致的呼吸系统、尿道、皮肤软组织、脑组织感染、败血症、细菌性心内膜炎等全身性严重感染，各种外科手术后感染等。
- Associated Conditions
- Bacterial Infections, Catheter-related Bloodstream Infection (CRBSI) NOS, Complicated Intra-Abdominal Infections (cIAIs), Complicated Urinary Tract Infection, Pyelonephritis
- Associated Therapies
- -
Ceftazidime-Avibactam Compared With Doripenem Followed by Oral Therapy for Hospitalized Adults With Complicated UTIs (Urinary Tract Infections)
- Conditions
- Interventions
- First Posted Date
- 2012-05-16
- Last Posted Date
- 2017-09-06
- Lead Sponsor
- Pfizer
- Target Recruit Count
- 641
- Registration Number
- NCT01599806
- Locations
- 🇺🇦
Research Site, Zaporizhzhya, Ukraine
Ceftazidime-Avibactam Compared With Doripenem Followed by Oral Therapy for Hospitalized Adults With Complicated UTIs (Urinary Tract Infections)
- Conditions
- Interventions
- First Posted Date
- 2012-05-10
- Last Posted Date
- 2017-09-06
- Lead Sponsor
- Pfizer
- Target Recruit Count
- 598
- Registration Number
- NCT01595438
- Locations
- 🇺🇦
Research Site, Zaporizhzhya, Ukraine
The Pharmacodynamics of Doripenem Between 4-hour and 1-hour Infusion in Patients With Ventilator-associated Pneumonia
- First Posted Date
- 2011-11-09
- Last Posted Date
- 2011-11-09
- Lead Sponsor
- Sutep Jaruratanasirikul
- Target Recruit Count
- 12
- Registration Number
- NCT01467648
- Locations
- 🇹🇭
Prince of Songkla University, Hat Yai, Songkla, Thailand
Pharmacokinetic/Pharmacodynamic Study of Doripenem in Febrile Neutropenic Patients
- First Posted Date
- 2011-07-25
- Last Posted Date
- 2015-10-14
- Lead Sponsor
- Gary E. Stein, Pharm.D.
- Target Recruit Count
- 12
- Registration Number
- NCT01401010
- Locations
- 🇺🇸
Sparrow Hospital, Lansing, Michigan, United States
A Study of Doripenem in Infants Less Than 12 Weeks of Age
- First Posted Date
- 2011-06-27
- Last Posted Date
- 2013-01-10
- Lead Sponsor
- Janssen Research & Development, LLC
- Target Recruit Count
- 52
- Registration Number
- NCT01381848
A Study of Doripenem in CerebrospinalFluid After Doripenem Administration in Pediatric Patients Less Than 1 Year of Age
- First Posted Date
- 2011-06-06
- Last Posted Date
- 2013-12-06
- Lead Sponsor
- Janssen Research & Development, LLC
- Target Recruit Count
- 1
- Registration Number
- NCT01366651
Target Site Pharmacokinetics of Doripenem After a Single Dose of 500mg in Healthy Volunteers Dori_MD_1
- First Posted Date
- 2011-03-09
- Last Posted Date
- 2011-04-01
- Lead Sponsor
- Medical University of Vienna
- Target Recruit Count
- 6
- Registration Number
- NCT01311141
- Locations
- 🇦🇹
Medical University of Vienna, Vienna, Austria
Comparative Study of Coadministered Ceftaroline Fosamil and NXL104 vs. Intravenous Doripenem in Adult Subjects With Complicated Urinary Tract Infections
- Conditions
- Interventions
- First Posted Date
- 2011-01-24
- Last Posted Date
- 2014-02-03
- Lead Sponsor
- Forest Laboratories
- Target Recruit Count
- 217
- Registration Number
- NCT01281462
- Locations
- 🇹🇷
Investigational Site, Izmir, Turkey
A Safety and Tolerability Study of Doripenem Compared With Cefepime in Hospitalized Children With Bacterial Pneumonia
- First Posted Date
- 2010-04-26
- Last Posted Date
- 2014-07-15
- Lead Sponsor
- Janssen Research & Development, LLC
- Target Recruit Count
- 7
- Registration Number
- NCT01110421
A Safety and Tolerability Study of Doripenem Compared With Cefepime in Children Hospitalized With Complicated Urinary Tract Infections
- First Posted Date
- 2010-04-26
- Last Posted Date
- 2014-07-15
- Lead Sponsor
- Janssen Research & Development, LLC
- Target Recruit Count
- 41
- Registration Number
- NCT01110408
Drug Development Updates
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