Acetylcysteine
- Generic Name
- Acetylcysteine
- Brand Names
- Acetadote
- Drug Type
- Small Molecule
- Chemical Formula
- C5H9NO3S
- CAS Number
- 616-91-1
- Unique Ingredient Identifier
- WYQ7N0BPYC
- Background
Acetylcysteine is an antioxidant and glutathione inducer indicated for mucolytic therapy and the treatment of acetaminophen overdose. Acetylcysteine has also been studied for a wide variety of off-label indications with mixed results.
Acetylcysteine was granted FDA approval on 14 September 1963.
- Indication
Acetylcysteine is indicated for mucolytic therapy and in the management of acetaminophen overdose.
- Associated Conditions
- Acetaminophen Overdose, Chronic Rhinitis, Corneal Diseases, Corneal ulceration, Crusting Rhinitis, Keratopathy, Rhinitis, Sinusitis, Vasomotor Rhinitis, Acute Rhinitis, Subacute Rhinitis
- Associated Therapies
- Airway secretion clearance therapy
Anti-Oxidant Effect on Peritoneal Membrane in Peritoneal Dialysis (PD) Patients
- First Posted Date
- 2010-04-27
- Last Posted Date
- 2010-04-27
- Lead Sponsor
- Ewha Womans University
- Target Recruit Count
- 66
- Registration Number
- NCT01111422
- Locations
- 🇰🇷
Ewha Womans University Mokdong Hospital, Seoul, Korea, Republic of
Effects of N-acetylcysteine on Diabetic Foot Oxygenation
- First Posted Date
- 2010-03-08
- Last Posted Date
- 2012-03-08
- Lead Sponsor
- University of Turin, Italy
- Target Recruit Count
- 100
- Registration Number
- NCT01082445
- Locations
- 🇮🇹
Div. Endocrinology, Diabetology and Metabolism - University of Turin, Turin, TO, Italy
NAC as a Potential Treatment for Methamphetamine Dependence
- Conditions
- Interventions
- First Posted Date
- 2010-02-05
- Last Posted Date
- 2012-07-27
- Lead Sponsor
- Baylor College of Medicine
- Target Recruit Count
- 10
- Registration Number
- NCT01063205
- Locations
- 🇺🇸
Michael E. DeBakey VA Medical Center, Houston, Texas, United States
Scottish and Newcastle Anti-emetic Pre-treatment for Paracetamol Poisoning Study (SNAP)
- First Posted Date
- 2010-01-15
- Last Posted Date
- 2013-07-31
- Lead Sponsor
- University of Edinburgh
- Target Recruit Count
- 222
- Registration Number
- NCT01050270
- Locations
- 🇬🇧
Aberdeen Royal Infirmary, Aberdeen, United Kingdom
🇬🇧Royal Infirmary of Edinburgh, Edinburgh, United Kingdom
🇬🇧Royal Victoria Infirmary, Newcastle upon Tyne, United Kingdom
ROS Signaling in Endothelial Function
- Conditions
- Interventions
- First Posted Date
- 2009-12-23
- Last Posted Date
- 2017-03-10
- Lead Sponsor
- Boston University
- Target Recruit Count
- 72
- Registration Number
- NCT01037465
- Locations
- 🇺🇸
Boston Medical Center, Boston, Massachusetts, United States
N-acetylcysteine in the Treatment of Bulimia Nervosa
- First Posted Date
- 2009-12-16
- Last Posted Date
- 2014-03-05
- Lead Sponsor
- Lindner Center of HOPE
- Target Recruit Count
- 11
- Registration Number
- NCT01033149
- Locations
- 🇺🇸
Lindner Center of HOPE, Mason, Ohio, United States
A Trial of N-Acetylcysteine (an Over-the-Counter Medicine) in Adolescents Who Smoke Marijuana
- Conditions
- Interventions
- First Posted Date
- 2009-11-01
- Last Posted Date
- 2018-11-21
- Lead Sponsor
- Medical University of South Carolina
- Target Recruit Count
- 116
- Registration Number
- NCT01005810
- Locations
- 🇺🇸
Medical University of South Carolina, Charleston, South Carolina, United States
N-acetyl-cysteine (NAC) and Kidney Graft Function
- First Posted Date
- 2009-10-21
- Last Posted Date
- 2011-07-12
- Lead Sponsor
- Institut d'Anesthesiologie des Alpes Maritimes
- Target Recruit Count
- 236
- Registration Number
- NCT00998972
- Locations
- 🇫🇷
CHU de Nice, NICE cedex 01, Alpes Maritimes, France
The Effect of Inhaled N-Acetylcysteine Compared to Normal Saline on Sputum Rheology and Lung Function
- First Posted Date
- 2009-10-16
- Last Posted Date
- 2011-08-15
- Lead Sponsor
- University Hospital, Ghent
- Target Recruit Count
- 19
- Registration Number
- NCT00996424
- Locations
- 🇧🇪
University Hospital Ghent, Ghent, Belgium
Protective Effect of N-acetylcysteine on Early Outcomes of Deceased Renal Transplant
- First Posted Date
- 2009-10-14
- Last Posted Date
- 2009-10-14
- Lead Sponsor
- University of Sao Paulo General Hospital
- Target Recruit Count
- 74
- Registration Number
- NCT00994305
- Locations
- 🇧🇷
University of Sao Paulo General Hospital Kidney Transplant Unit, Sao Paulo, Brazil
Drug Development Updates
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