Acetylcysteine
- Generic Name
- Acetylcysteine
- Brand Names
- Acetadote
- Drug Type
- Small Molecule
- Chemical Formula
- C5H9NO3S
- CAS Number
- 616-91-1
- Unique Ingredient Identifier
- WYQ7N0BPYC
- Background
Acetylcysteine is an antioxidant and glutathione inducer indicated for mucolytic therapy and the treatment of acetaminophen overdose. Acetylcysteine has also been studied for a wide variety of off-label indications with mixed results.
Acetylcysteine was granted FDA approval on 14 September 1963.
- Indication
Acetylcysteine is indicated for mucolytic therapy and in the management of acetaminophen overdose.
- Associated Conditions
- Acetaminophen Overdose, Chronic Rhinitis, Corneal Diseases, Corneal ulceration, Crusting Rhinitis, Keratopathy, Rhinitis, Sinusitis, Vasomotor Rhinitis, Acute Rhinitis, Subacute Rhinitis
- Associated Therapies
- Airway secretion clearance therapy
N-acetylcysteine in Liver Transplantation
- First Posted Date
- 2008-08-18
- Last Posted Date
- 2023-04-28
- Lead Sponsor
- Ibtesam Hilmi
- Target Recruit Count
- 100
- Registration Number
- NCT00736541
- Locations
- 🇺🇸
Unversity of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, United States
Safety of N-acetylcysteine in Maternal Chorioamnionitis (NAC in Chorio)
- Conditions
- Interventions
- First Posted Date
- 2008-07-29
- Last Posted Date
- 2021-04-12
- Lead Sponsor
- Medical University of South Carolina
- Target Recruit Count
- 46
- Registration Number
- NCT00724594
- Locations
- 🇺🇸
Medical University of South Carolina, Charleston, South Carolina, United States
Effect of Hydration With Sodium Bicarbonate for Long-Term Clinical Outcomes in Patients With Chronic Kidney Disease Undergoing an Emergent Coronary Procedure
- First Posted Date
- 2008-07-15
- Last Posted Date
- 2008-07-15
- Lead Sponsor
- Osaka General Medical Center
- Registration Number
- NCT00716001
Modulation of Lung Injury Complicating Lung Resection
- First Posted Date
- 2008-04-10
- Last Posted Date
- 2020-02-05
- Lead Sponsor
- Imperial College London
- Target Recruit Count
- 52
- Registration Number
- NCT00655928
- Locations
- 🇬🇧
Royal Brompton Hospital, London, United Kingdom
Study of the Effects of High-dose N-acetylcysteine (NAC) in Idiopathic Pulmonary Fibrosis (IPF)
- First Posted Date
- 2008-03-20
- Last Posted Date
- 2015-03-05
- Lead Sponsor
- Zambon SpA
- Target Recruit Count
- 184
- Registration Number
- NCT00639496
- Locations
- 🇧🇪
U.Z. Ghent, Gent, Belgium
🇫🇷Hôpital A. Calmette, Lille Cedex, France
🇩🇪Klinikum Grosshadern, Munich, Germany
N-AcetylCysteine vs. Placebo to Prevent Neurotoxicity Induced by Platinum Containing Chemotherapy
- Conditions
- Interventions
- First Posted Date
- 2008-03-18
- Last Posted Date
- 2022-08-25
- Lead Sponsor
- Rijnstate Hospital
- Target Recruit Count
- 69
- Registration Number
- NCT00637624
- Locations
- 🇳🇱
Rijnstate Hospital, Arnhem, Gelderland, Netherlands
Safety Study Of N-Acetylcysteine For Prevention Of Contrast Induced Nephropathy In Patients w/Stage 3 Renal Failure
- First Posted Date
- 2007-12-18
- Last Posted Date
- 2019-08-02
- Lead Sponsor
- Oregon Health and Science University
- Target Recruit Count
- 6
- Registration Number
- NCT00575419
- Locations
- 🇺🇸
Oregon Health & Science University, Portland, Oregon, United States
N-Acetylcysteine and Arginine Administration in Diabetic Patients
- Conditions
- Interventions
- First Posted Date
- 2007-12-07
- Last Posted Date
- 2007-12-07
- Lead Sponsor
- University of Turin, Italy
- Target Recruit Count
- 24
- Registration Number
- NCT00569465
- Locations
- 🇮🇹
"San Giovanni Battista" Hospital of Turin, Turin, Italy
N-acetylcysteine in Alcohol Dependence
- First Posted Date
- 2007-12-05
- Last Posted Date
- 2020-03-18
- Lead Sponsor
- Minneapolis Veterans Affairs Medical Center
- Target Recruit Count
- 46
- Registration Number
- NCT00568087
- Locations
- 🇺🇸
Minneapolis VA Medical Center, Minneapolis, Minnesota, United States
Mechanisms for the Effect of Acetylcysteine on Renal Function After Exposure to Radiographic Contrast Material
- Conditions
- Interventions
- First Posted Date
- 2007-11-14
- Last Posted Date
- 2015-06-08
- Lead Sponsor
- University of Edinburgh
- Target Recruit Count
- 90
- Registration Number
- NCT00558142
- Locations
- 🇬🇧
Clinical Research Facility, Royal Infirmary Edinburgh, Edinburgh, Midlothian, United Kingdom
Drug Development Updates
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