Prednisone
- Generic Name
- Prednisone
- Brand Names
- Deltasone, Rayos, Winpred
- Drug Type
- Small Molecule
- Chemical Formula
- C21H26O5
- CAS Number
- 53-03-2
- Unique Ingredient Identifier
- VB0R961HZT
- Background
A synthetic anti-inflammatory glucocorticoid derived from cortisone. It is biologically inert and converted to prednisolone in the liver.
Prednisone was granted FDA approval on 21 February 1955.
- Indication
Prednisone is indicated as an anti-inflammatory or immunosuppressive drug for allergic, dermatologic, gastrointestinal, hematologic, ophthalmologic, nervous system, renal, respiratory, rheumatologic, infectious, endocrine, or neoplastic conditions as well as in organ transplant.
- Associated Conditions
- Acne Vulgaris, Acute Exacerbation of Chronic Obstructive Pulmonary Disease, Acute Gouty Arthritis, Acute Leukemia, Aggressive Lymphoma, Allergic Bronchopulmonary Aspergillosis, Allergic Conjunctivitis (AC), Allergic Rhinitis (AR), Allergic corneal marginal ulcers, Alveolitis, Extrinsic Allergic, Ankylosing Spondylitis (AS), Aspiration Pneumonitis, Asthma, Atopic Dermatitis, Autoimmune Hepatitis, Bell's Palsy, Berylliosis, Bullous dermatitis herpetiformis, Chorioretinitis, Congenital Adrenal Hyperplasia (CAH), Congenital Hypoplastic Anemia, Contact Dermatitis, Disseminated tuberculosis, Drug hypersensitivity reaction, Edema of the cerebrum, Epicondylitis, Erythroblastopenia, Giant Cell Arteritis (GCA), Hypercalcemia of Malignancy, Idiopathic Pulmonary Fibrosis (IPF), Immune Thrombocytopenia (ITP), Iridocyclitis, Iritis, Keratitis, Leukemias, Loeffler's syndrome, Lymphoma, Meningitis caused by Mycobacterium Tuberculosis, Metastatic Castration-Resistant Prostate Cancer (mCRPC), Mycosis Fungoides (MF), Ocular Inflammation, Ophthalmia, Sympathetic, Optic Neuritis, Pain caused by Herpes zoster, Pemphigus, Pericarditis, Pneumocystis Jirovecii Pneumonia, Polymyalgia Rheumatica (PMR), Polymyositis, Posterior Uveitis, Primary adrenocortical insufficiency, Psoriatic Arthritis, Pure Red Cell Aplasia, Regional Enteritis, Relapsing Polychondritis, Rheumatoid Arthritis, Rheumatoid Arthritis, Juvenile, Secondary adrenocortical insufficiency, Secondary thrombocytopenia, Serum Sickness, Severe Seborrheic Dermatitis, Sjogren's Syndrome (SS), Solid Organ Transplant Rejection, Stevens-Johnson Syndrome, Systemic Lupus Erythematosus, Takayasu Arteritis, Thyroid Eye Disease, Thyroiditis, Thyrotoxicosis, Trichinosis, Ulcerative Colitis, Uveitis, Vasculitis, Acquired immune hemolytic anemia, Acute Bursitis, Acute Crohn's Disease (CD), Acute Multiple sclerosis exacerbation, Acute rheumatic carditis, Anterior eye segment inflammation, Exfoliative erythroderma, Fulminating Tuberculosis, Idiopathic Bronchiolitis obliterans with organizing pneumonia, Idiopathic eosinophilic pneumonias, Non-suppurative Thyroiditis, Severe Psoriasis, Subacute Bursitis, Symptomatic Sarcoidosis, Synovitis of osteoarthritis, Systemic Dermatomyositis, Varicella-zoster virus acute retinal necrosis
- Associated Therapies
- Palliative Treatment
Efficacy and Safety of Adalimumab in Patients With Active Uveitis
- First Posted Date
- 2010-06-07
- Last Posted Date
- 2021-07-07
- Lead Sponsor
- AbbVie (prior sponsor, Abbott)
- Target Recruit Count
- 239
- Registration Number
- NCT01138657
Chemotherapy Based on Positron Emission Tomography Scan in Treating Patients With Stage I or Stage II Hodgkin Lymphoma
- Conditions
- Lymphoma
- Interventions
- Biological: Bleomycin SulfateDrug: Doxorubicin HydrochlorideDrug: Procarbazine HydrochlorideDrug: Vinblastine SulfateDrug: DacarbazineDrug: CyclophosphamideDrug: Etoposide phosphateDrug: prednisoneDrug: Radiation TherapyRadiation: Fludeoxyglucose F-18Procedure: computed tomographyProcedure: Positron Emission Tomography
- First Posted Date
- 2010-05-28
- Last Posted Date
- 2021-06-14
- Lead Sponsor
- Alliance for Clinical Trials in Oncology
- Target Recruit Count
- 164
- Registration Number
- NCT01132807
- Locations
- 🇺🇸
Frank M. and Dorothea Henry Cancer Center at Geisinger Wyoming Valley Medical Center, Wilkes-Barre, Pennsylvania, United States
🇺🇸UMASS Memorial Cancer Center - University Campus, Worcester, Massachusetts, United States
🇺🇸Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland, United States
Lenalidomide and Prednisone in Low and Int-1 Myelodysplastic Syndrome (MDS) Non 5q MDS
- Conditions
- Myelodysplastic SyndromeMDS
- Interventions
- First Posted Date
- 2010-05-28
- Last Posted Date
- 2019-12-17
- Lead Sponsor
- H. Lee Moffitt Cancer Center and Research Institute
- Target Recruit Count
- 28
- Registration Number
- NCT01133275
- Locations
- 🇺🇸
University of Florida Shands Cancer Center, Gainesville, Florida, United States
🇺🇸H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, United States
Efficacy and Safety of Adalimumab in Subjects With Inactive Uveitis
- First Posted Date
- 2010-05-17
- Last Posted Date
- 2021-07-07
- Lead Sponsor
- AbbVie (prior sponsor, Abbott)
- Target Recruit Count
- 261
- Registration Number
- NCT01124838
OGX-427 in Castration Resistant Prostate Cancer Patients
- Conditions
- Castration Resistant Prostate Cancer
- Interventions
- Drug: OGX-427Drug: Prednisone
- First Posted Date
- 2010-05-11
- Last Posted Date
- 2019-02-15
- Lead Sponsor
- British Columbia Cancer Agency
- Target Recruit Count
- 74
- Registration Number
- NCT01120470
- Locations
- 🇨🇦
CancerCare Manitoba, Winnipeg, Manitoba, Canada
🇨🇦BC Cancer Agency - Vancouver Centre, Vancouver, British Columbia, Canada
🇨🇦BC Cancer Agency - Centre for the Southern Interior, Kelowna, British Columbia, Canada
International Collaborative Treatment Protocol For Children And Adolescents With Acute Lymphoblastic Leukemia
- Conditions
- Leukemia
- Interventions
- Drug: PEG-L-asparaginaseDrug: cyclophosphamideDrug: cytarabineDrug: daunorubicin hydrochlorideDrug: dexamethasoneDrug: doxorubicin hydrochlorideDrug: etoposideDrug: mercaptopurineDrug: ifosfamideDrug: methotrexateDrug: vincristine sulfateDrug: prednisoneRadiation: Radiation TherapyDrug: thioguanineDrug: vindesineDrug: daunoxomeDrug: fludarabine
- First Posted Date
- 2010-05-05
- Last Posted Date
- 2022-05-24
- Lead Sponsor
- University Hospital Schleswig-Holstein
- Target Recruit Count
- 6136
- Registration Number
- NCT01117441
- Locations
- 🇦🇹
A.oe. Landeskrankenhaus Klagenfurt, Abt. für Kinder- und Jugendheilkunde, Klagenfurt, Austria
🇨🇿University Hospital Brno, Department of Pediatric Oncology, Brno, Czechia
🇩🇪Klinikum Berlin-Buch II. Kinderklinik, Bereich Onkologie/Allg. Pädiatrie, Berlin, Germany
Dasatinib in Combination With Melphalan and Prednisone to Treat Relapsed and Refractory Multiple Myeloma Patients
- First Posted Date
- 2010-05-04
- Last Posted Date
- 2011-06-14
- Lead Sponsor
- Fondazione EMN Italy Onlus
- Target Recruit Count
- 8
- Registration Number
- NCT01116128
- Locations
- 🇮🇹
Mario Boccadoro, Torino, Italy
Neo-adjuvant Abiraterone + Luteinizing Hormone-Releasing Hormone (LHRH) Versus LHRH in Prostate Cancer
- Conditions
- Prostate Cancer
- Interventions
- First Posted Date
- 2010-03-17
- Last Posted Date
- 2014-05-15
- Lead Sponsor
- Cougar Biotechnology, Inc.
- Target Recruit Count
- 66
- Registration Number
- NCT01088529
Rituximab for Treatment of Systemic Sclerosis-Associated Pulmonary Arterial Hypertension (SSc-PAH)
- Conditions
- Systemic Sclerosis-Associated PAH
- Interventions
- Biological: RituximabOther: PlaceboDiagnostic Test: CMRIDrug: prednisoneDrug: methylprednisoloneDrug: diphenhydramineDrug: acetaminophen
- First Posted Date
- 2010-03-15
- Last Posted Date
- 2023-02-21
- Target Recruit Count
- 57
- Registration Number
- NCT01086540
- Locations
- 🇺🇸
University of Colorado Health Sciences Center, Aurora, Colorado, United States
🇺🇸University of Minnesota Health Clinics and Surgery Center, Minneapolis, Minnesota, United States
🇺🇸Boston University Medical Center, Boston, Massachusetts, United States
Study of TAK-700 in Combination With Docetaxel and Prednisone in Men With Metastatic Castration-Resistant Prostate Cancer
- First Posted Date
- 2010-03-10
- Last Posted Date
- 2019-07-30
- Lead Sponsor
- Millennium Pharmaceuticals, Inc.
- Target Recruit Count
- 38
- Registration Number
- NCT01084655
- Locations
- 🇺🇸
Alaska Clinical Research Center, LLC, Anchorage, Alaska, United States
Drug Development Updates
Stay informed with timely notifications on clinical trials, regulatory changes, and research advancements related to this medication.