Diphenhydramine

Generic Name: Diphenhydramine

Brand Names: Acetadryl, Advil PM, Aleve PM, Allegra Cooling Relief Anti-itch, Banophen, Benadryl, Benadryl Itch Stopping, Benadryl-D Allergy and Sinus, Calagel, Damylin With Codeine, Dimetapp Nighttime Cold & Congestion, Diphen, Diphenhist, Diphenist, Excedrin PM Triple Action, Goody's PM, Legatrin PM, Motrin PM, Nytol, Nytol Quickgels, Percogesic Reformulated Jan 2011, Siladryl, Simply Sleep, Sleepinal, Sominex, Triaminic Night Time Cold & Cough, Tylenol PM, Unisom, Unisom Sleep, Vanamine, Wal-dryl, Wal-som (doxylamine), Zzzquil

Drug Type: Small Molecule

Chemical Formula: C_₁₇H_₂₁NO

CAS Number: 58-73-1

Unique Ingredient Identifier: 8GTS82S83M

Background: Diphenhydramine - perhaps known most commonly as its brand name formulation Benadryl - is a first-generation H1 receptor antihistamine that is used extensively for the treatment of seasonal allergies, insect bites and stings, and rashes . However, it also has antiemetic, antitussive, hypnotic, and antiparkinson properties . As histamine receptors exist both ...

Indication: Diphenhydramine is a first-generation histamine H1 receptor antagonist (H1 antihistamine) that is widely available as a non-prescription, over-the-counter (OTC) medication. As an OTC medication, diphenhydramine is typically formulated as tablets and creams indicated for use in treating sneezing, runny nose, itchy/watery eyes, itching of nose or throat, insom...

Associated Conditions: Allergic Reaction, Allergic Rhinitis (AR), Allergic cough, Allergy to Tree Pollen, Anaphylaxis, Angioedema, Common Cold, Conjunctival irritation, Cough, Cough Variant Asthma, Cough caused by Common Cold, Eye allergy, Fever, Insect Bites, Insect Stings, Insomnia, Irritative cough, Itching of the nose, Itching of the throat, Motion Sickness, Nasal Congestion, Oral Mucositis, Pain, Parkinsonian Syndromes, Productive cough, Pruritus, Rash, Rhinorrhoea, Sinus Congestion, Sinus headache, Skin Irritation, Sneezing, Sunburn, Symptoms of Acute Bronchitis Accompanied by Coughing, Upper respiratory tract hypersensitivity reaction, site unspecified, Urticaria, Cold or flu syndrome, Dermatographism, Dry cough, Watery itchy eyes

Associated Therapies: Airway secretion clearance therapy, Expectorant

Clinical Trials

Study to Assess the Effect of Gabapentin Enacarbil on Simulated Driving in Healthy Subjects

Phase 1

Completed

Conditions: Restless Legs Syndrome (RLS)

Interventions: Drug: gabapentin enacarbil
Drug: diphenhydramine
Drug: placebo

First Posted Date: 2011-08-08

Last Posted Date: 2013-07-16

Lead Sponsor: XenoPort, Inc.

Target Recruit Count: 36

Registration Number: NCT01411124

Locations: 🇺🇸
GSK Investigational Site, Austin, Texas, United States

Pazopanib Versus Temsirolimus in Poor-Risk Clear-Cell Renal Cell Carcinoma (RCC)

Phase 2

Completed

Conditions: Kidney Cancer

Interventions: Drug: Temsirolimus
Drug: Pazopanib
Behavioral: Quality of Life Assessment
Drug: Benadryl

First Posted Date: 2011-07-12

Last Posted Date: 2021-09-20

Lead Sponsor: M.D. Anderson Cancer Center

Target Recruit Count: 69

Registration Number: NCT01392183

Locations: 🇺🇸
University of Texas MD Anderson Cancer Center, Houston, Texas, United States

Simulated Driving Study in Restless Legs Syndrome

Phase 2

Completed

Conditions: Restless Legs Syndrome

Interventions: Drug: Placebo
Drug: XP13512
Drug: Diphenhydramine

First Posted Date: 2011-04-11

Last Posted Date: 2013-07-26

Lead Sponsor: XenoPort, Inc.

Target Recruit Count: 130

Registration Number: NCT01332318

Locations: 🇺🇸
GSK Investigational Site, Albuquerque, New Mexico, United States

TPI 287 in Breast Cancer Metastatic to the Brain

Phase 2

Completed

Conditions: Breast Cancer

Interventions: Drug: TPI 287
Drug: Dexamethasone
Drug: Benadryl
Drug: Ranitidine

First Posted Date: 2011-04-11

Last Posted Date: 2018-09-20

Lead Sponsor: M.D. Anderson Cancer Center

Target Recruit Count: 24

Registration Number: NCT01332630

Locations: 🇺🇸
University of Texas MD Anderson Cancer Center, Houston, Texas, United States

Pharmacogenetic Factors and Side Effects of Metoclopramide and Diphenhydramine

Phase 1

Terminated

Conditions: Drug Metabolism, Poor, CYP2D6-RELATED

Interventions: Drug: Metoclopramide
Drug: Diphenhydramine

First Posted Date: 2011-02-04

Last Posted Date: 2016-05-13

Lead Sponsor: Matthias Schwab

Target Recruit Count: 49

Registration Number: NCT01289938

Locations: 🇩🇪
Abteilung Klinische Pharmakologie, UKT Tübingen, Tübingen, BW, Germany

A Safety Study of Xolair (Omalizumab) in Patients With Chronic Idiopathic Urticaria (CIU) Who Remain Symptomatic Despite Treatment With H1 Antihistamines, H2 Blockers, and/or Leukotriene Receptor Antagonists

Phase 3

Completed

Conditions: Chronic Idiopathic Urticaria

Interventions: Drug: Placebo
Drug: Omalizumab
Drug: H1 antihistamine, H2 antihistamine, leukotriene receptor antagonist
Drug: Diphenhydramine

First Posted Date: 2010-12-22

Last Posted Date: 2013-11-26

Lead Sponsor: Genentech, Inc.

Target Recruit Count: 336

Registration Number: NCT01264939

Study To Assess The Effect Of Gabapentin, Diphenhydramine And Morphine On Cold Pain In Healthy Male Volunteers

Phase 1

Completed

Conditions: Healthy

Interventions: Drug: Placebo
Drug: Gabapentin
Drug: Morphine
Drug: Diphenhydramine

First Posted Date: 2010-05-07

Last Posted Date: 2011-03-07

Lead Sponsor: Pfizer

Target Recruit Count: 19

Registration Number: NCT01119222

Locations: 🇧🇪
Pfizer Investigational Site, Bruxelles, Belgium

Efficacy and Safety of the Herbal Medicine Sominex ® (Passiflora Incarnata L., Valeriana Officinalis L. and Crataegus Oxyacantha L.), Manufactured by the Laboratory EMS S / A in Patients With Psychophysiological Insomnia

Phase 3

Conditions: Insomnia

Interventions: Drug: Sominex
Drug: Placebo

First Posted Date: 2010-04-09

Last Posted Date: 2010-10-28

Lead Sponsor: Azidus Brasil

Target Recruit Count: 100

Registration Number: NCT01100645

Locations: 🇧🇷
LAL Clinica Pesquisa e Desenvolvimento Ltda, Valinhos, São Paulo, Brazil

Rituximab for Treatment of Systemic Sclerosis-Associated Pulmonary Arterial Hypertension (SSc-PAH)

Phase 2

Completed

Conditions: Systemic Sclerosis-Associated PAH

Interventions: Biological: Rituximab
Other: Placebo
Diagnostic Test: CMRI
Drug: prednisone
Drug: methylprednisolone
Drug: diphenhydramine
Drug: acetaminophen

First Posted Date: 2010-03-15

Last Posted Date: 2023-02-21

Lead Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Target Recruit Count: 57

Registration Number: NCT01086540

Locations: 🇺🇸
University of Colorado Health Sciences Center, Aurora, Colorado, United States
🇺🇸
University of Minnesota Health Clinics and Surgery Center, Minneapolis, Minnesota, United States
🇺🇸
Boston University Medical Center, Boston, Massachusetts, United States

and more 14 locations

Rescue Emetic Therapy for Children Having Elective Surgery

Not Applicable

Withdrawn

Conditions: Post Operative Nausea and Vomiting
Rescue Emetic Therapy

Interventions: Drug: Saline
Drug: Metaclopramide
Drug: diphenhydramine
Drug: Ondansetron

First Posted Date: 2010-02-11

Last Posted Date: 2017-11-14

Lead Sponsor: Franklyn Cladis

Registration Number: NCT01067677

Locations: 🇺🇸
The Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania, United States

Drug Development Updates

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