Diphenhydramine

Generic Name: Diphenhydramine

Brand Names: Acetadryl, Advil PM, Aleve PM, Allegra Cooling Relief Anti-itch, Banophen, Benadryl, Benadryl Itch Stopping, Benadryl-D Allergy and Sinus, Calagel, Damylin With Codeine, Dimetapp Nighttime Cold & Congestion, Diphen, Diphenhist, Diphenist, Excedrin PM Triple Action, Goody's PM, Legatrin PM, Motrin PM, Nytol, Nytol Quickgels, Percogesic Reformulated Jan 2011, Siladryl, Simply Sleep, Sleepinal, Sominex, Triaminic Night Time Cold & Cough, Tylenol PM, Unisom, Unisom Sleep, Vanamine, Wal-dryl, Wal-som (doxylamine), Zzzquil

Drug Type: Small Molecule

Chemical Formula: C_₁₇H_₂₁NO

CAS Number: 58-73-1

Unique Ingredient Identifier: 8GTS82S83M

Background: Diphenhydramine - perhaps known most commonly as its brand name formulation Benadryl - is a first-generation H1 receptor antihistamine that is used extensively for the treatment of seasonal allergies, insect bites and stings, and rashes . However, it also has antiemetic, antitussive, hypnotic, and antiparkinson properties . As histamine receptors exist both ...

Indication: Diphenhydramine is a first-generation histamine H1 receptor antagonist (H1 antihistamine) that is widely available as a non-prescription, over-the-counter (OTC) medication. As an OTC medication, diphenhydramine is typically formulated as tablets and creams indicated for use in treating sneezing, runny nose, itchy/watery eyes, itching of nose or throat, insom...

Associated Conditions: Allergic Reaction, Allergic Rhinitis (AR), Allergic cough, Allergy to Tree Pollen, Anaphylaxis, Angioedema, Common Cold, Conjunctival irritation, Cough, Cough Variant Asthma, Cough caused by Common Cold, Eye allergy, Fever, Insect Bites, Insect Stings, Insomnia, Irritative cough, Itching of the nose, Itching of the throat, Motion Sickness, Nasal Congestion, Oral Mucositis, Pain, Parkinsonian Syndromes, Productive cough, Pruritus, Rash, Rhinorrhoea, Sinus Congestion, Sinus headache, Skin Irritation, Sneezing, Sunburn, Symptoms of Acute Bronchitis Accompanied by Coughing, Upper respiratory tract hypersensitivity reaction, site unspecified, Urticaria, Cold or flu syndrome, Dermatographism, Dry cough, Watery itchy eyes

Associated Therapies: Airway secretion clearance therapy, Expectorant

Clinical Trials

A Study to Investigate Subcutaneous Isatuximab in Combination With Carfilzomib and Dexamethasone in Adult Participants With Relapsed and/or Refractory Multiple Myeloma

Phase 2

Active, not recruiting

Conditions: Relapsed/Refractory Multiple Myeloma

Interventions: Drug: Isatuximab
Drug: Carfilzomib
Drug: Dexamethasone
Drug: Dexamethasone IV
Drug: Montelukast
Drug: Acetaminophen
Drug: Diphenhydramine
Drug: Methylprednisolone

First Posted Date: 2023-01-30

Last Posted Date: 2024-11-14

Lead Sponsor: Sanofi

Target Recruit Count: 74

Registration Number: NCT05704049

Locations: 🇦🇺
Investigational Site Number : 0360002, Wollongong, New South Wales, Australia
🇧🇷
Hospital Mae de Deus Site Number : 0760002, Porto Alegre, Rio Grande Do Sul, Brazil
🇦🇺
Investigational Site Number : 0360001, Fitzroy, Victoria, Australia

and more 14 locations

Sodium Bicarbonate for Acute Peripheral Vertigo

Not Applicable

Recruiting

Conditions: Peripheral Vertigo

Interventions: Drug: Diphenhydramine + Sodium Bicarbonate
Drug: Diphenhydramine
Drug: Sodium Bicarbonate

First Posted Date: 2023-01-09

Last Posted Date: 2023-07-12

Lead Sponsor: National Taiwan University Hospital

Target Recruit Count: 225

Registration Number: NCT05676216

Locations: 🇨🇳
National Taiwan University Yunlin Branch, Yunlin County, Taiwan

Diphenhydramine and Sweating

Phase 4

Completed

Conditions: Sweating
Diphenhydramine Causing Adverse Effects in Therapeutic Use
Allergic Rhinitis
Hyperthermia

Interventions: Drug: Placebo
Drug: Diphenhydramine

First Posted Date: 2022-10-19

Last Posted Date: 2023-09-13

Lead Sponsor: Lakehead University

Target Recruit Count: 20

Registration Number: NCT05586477

Locations: 🇨🇦
Lakehead Unviersity, Thunder Bay, Ontario, Canada

Trial of Diphenhydramine for Sleep in Children With Autism

Phase 2

Recruiting

Conditions: Autism
Autism Spectrum Disorder

Interventions: Drug: Diphenhydramine
Drug: Placebo

First Posted Date: 2022-08-15

Last Posted Date: 2024-12-16

Lead Sponsor: Stanford University

Target Recruit Count: 26

Registration Number: NCT05501678

Locations: 🇺🇸
Stanford University, Stanford, California, United States

SC Versus IV Isatuximab in Combination With Pomalidomide and Dexamethasone in RRMM

Phase 3

Active, not recruiting

Conditions: Plasma Cell Myeloma Recurrent

Interventions: Drug: Isatuximab SC
Drug: Isatuximab IV
Drug: Dexamethasone
Drug: Pomalidomide
Drug: Montelukast
Drug: Paracetamol / Acetaminophen
Drug: Diphenhydramine
Drug: Methylprednisolone

First Posted Date: 2022-06-06

Last Posted Date: 2024-11-14

Lead Sponsor: Sanofi

Target Recruit Count: 531

Registration Number: NCT05405166

Locations: 🇺🇸
Arizona Oncology Associates, PC - HAL- Site Number : 8400015, Prescott Valley, Arizona, United States
🇺🇸
Rocky Mountain Cancer Centers, LLP- Site Number : 8400021, Aurora, Colorado, United States
🇺🇸
Mayo Clinic- Site Number : 8400008, Jacksonville, Florida, United States

and more 143 locations

A Study Exploring Efficacy of Pegloticase in Subjects With Asymptomatic Hyperuricemia

Phase 1

Completed

Conditions: Asymptomatic Hyperuricemia

Interventions: Drug: SIBP-R002
Drug: Dexamethasone or Methyl prednisolone
Drug: Placebo
Drug: Diphenhydramine

First Posted Date: 2022-03-31

Last Posted Date: 2023-12-27

Lead Sponsor: Shanghai Institute Of Biological Products

Target Recruit Count: 45

Registration Number: NCT05302388

Locations: 🇨🇳
The first affiliated hospital of Bengbu medical college, Bengbu, Anhui, China

A Phase II Study of Vibecotamab (XmAb14045) for MRD- Positive AML and MDS After Hypomethylating Agent Failure

Phase 2

Recruiting

Conditions: AML
MDS

Interventions: Drug: Vibecotamab
Drug: Dexamethasone
Drug: Acetaminophen
Drug: Diphenhydramine

First Posted Date: 2022-03-18

Last Posted Date: 2024-11-01

Lead Sponsor: M.D. Anderson Cancer Center

Target Recruit Count: 42

Registration Number: NCT05285813

Locations: 🇺🇸
M D Anderson Cancer Center, Houston, Texas, United States

Droperidol on Prevention of Cannabis Hyperemesis Syndrome

Phase 3

Recruiting

Conditions: Cannabis Hyperemesis Syndrome

Interventions: Drug: Droperidol Injectable Product
Drug: Diphenhydramine

First Posted Date: 2022-02-17

Last Posted Date: 2023-01-20

Lead Sponsor: Mercy Health Ohio

Target Recruit Count: 45

Registration Number: NCT05244460

Locations: 🇺🇸
Mercy Health - Austintown, Austintown, Ohio, United States
🇺🇸
St. Joseph-Warren Hospital, Warren, Ohio, United States
🇺🇸
St Elizabeth Youngstown Hospital, Youngstown, Ohio, United States

and more 1 locations