Diphenhydramine

Generic Name
Diphenhydramine
Brand Names
Acetadryl, Advil PM, Aleve PM, Allegra Cooling Relief Anti-itch, Banophen, Benadryl, Benadryl Itch Stopping, Benadryl-D Allergy and Sinus, Calagel, Damylin With Codeine, Dimetapp Nighttime Cold & Congestion, Diphen, Diphenhist, Diphenist, Excedrin PM Triple Action, Goody's PM, Legatrin PM, Motrin PM, Nytol, Nytol Quickgels, Percogesic Reformulated Jan 2011, Siladryl, Simply Sleep, Sleepinal, Sominex, Triaminic Night Time Cold & Cough, Tylenol PM, Unisom, Unisom Sleep, Vanamine, Wal-dryl, Wal-som (doxylamine), Zzzquil
Drug Type
Small Molecule
Chemical Formula
C17H21NO
CAS Number
58-73-1
Unique Ingredient Identifier
8GTS82S83M
Background

Diphenhydramine - perhaps known most commonly as its brand name formulation Benadryl - is a first-generation H1 receptor antihistamine that is used extensively for the treatment of seasonal allergies, insect bites and stings, and rashes . However, it also has antiemetic, antitussive, hypnotic, and antiparkinson properties . As histamine receptors exist both ...

Indication

Diphenhydramine is a first-generation histamine H1 receptor antagonist (H1 antihistamine) that is widely available as a non-prescription, over-the-counter (OTC) medication. As an OTC medication, diphenhydramine is typically formulated as tablets and creams indicated for use in treating sneezing, runny nose, itchy/watery eyes, itching of nose or throat, insom...

Associated Conditions
Allergic Reaction, Allergic Rhinitis (AR), Allergic cough, Allergy to Tree Pollen, Anaphylaxis, Angioedema, Common Cold, Conjunctival irritation, Cough, Cough Variant Asthma, Cough caused by Common Cold, Eye allergy, Fever, Insect Bites, Insect Stings, Insomnia, Irritative cough, Itching of the nose, Itching of the throat, Motion Sickness, Nasal Congestion, Oral Mucositis, Pain, Parkinsonian Syndromes, Productive cough, Pruritus, Rash, Rhinorrhoea, Sinus Congestion, Sinus headache, Skin Irritation, Sneezing, Sunburn, Symptoms of Acute Bronchitis Accompanied by Coughing, Upper respiratory tract hypersensitivity reaction, site unspecified, Urticaria, Cold or flu syndrome, Dermatographism, Dry cough, Watery itchy eyes
Associated Therapies
Airway secretion clearance therapy, Expectorant

Study of Hyperthermic Intraperitoneal Chemoperfusion (HIPEC) in Patients With Gastric Adenocarcinoma and Carcinomatosis or Positive Cytology

First Posted Date
2017-11-06
Last Posted Date
2023-04-21
Lead Sponsor
M.D. Anderson Cancer Center
Target Recruit Count
29
Registration Number
NCT03330028
Locations
🇺🇸

University of Texas MD Anderson Cancer Center, Houston, Texas, United States

Evaluation of SAR408701 in Japanese Patients With Advanced Malignant Solid Tumors

First Posted Date
2017-10-27
Last Posted Date
2023-01-09
Lead Sponsor
Sanofi
Target Recruit Count
34
Registration Number
NCT03324113
Locations
🇯🇵

Investigational Site Number 3920002, Nagoya-Shi, Japan

🇯🇵

Investigational Site Number 3920003, Kashiwa-Shi, Japan

🇯🇵

Investigational Site Number 3920001, Sunto-Gun, Japan

Metoclopramide for Post Traumatic Headache

First Posted Date
2017-07-18
Last Posted Date
2021-11-09
Lead Sponsor
Montefiore Medical Center
Target Recruit Count
160
Registration Number
NCT03220958
Locations
🇺🇸

Montefiore Medical Center, Bronx, New York, United States

A Multiple Dose Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of BMS-986263 in Healthy Participants

First Posted Date
2017-05-05
Last Posted Date
2018-01-12
Lead Sponsor
Bristol-Myers Squibb
Target Recruit Count
33
Registration Number
NCT03142165
Locations
🇺🇸

Wcct Global, Llc, Cypress, California, United States

Metoclopramide for Post-Traumatic Headache. A Pilot Study

First Posted Date
2017-02-17
Last Posted Date
2018-07-31
Lead Sponsor
Montefiore Medical Center
Target Recruit Count
21
Registration Number
NCT03056352
Locations
🇺🇸

Montefiore Medical Center, Bronx, New York, United States

Safety and Efficacy of Isatuximab in Lymphoblastic Leukemia

First Posted Date
2016-12-21
Last Posted Date
2022-03-21
Lead Sponsor
Sanofi
Target Recruit Count
14
Registration Number
NCT02999633
Locations
🇺🇸

Investigational Site Number 8400001, Houston, Texas, United States

🇺🇸

Investigational Site Number 8400002, Atlanta, Georgia, United States

🇫🇮

Investigational Site Number 2460001, Helsinki, Finland

and more 14 locations

Efficacy of Haloperidol vs. Metoclopramide for Treatment of Acute Headaches and Migraines in the Emergency Department

First Posted Date
2016-11-23
Last Posted Date
2018-10-23
Lead Sponsor
OhioHealth
Target Recruit Count
66
Registration Number
NCT02972502
Locations
🇺🇸

OhioHealth Doctors Hospital, Columbus, Ohio, United States

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