Secretin human

Generic Name
Secretin human
Brand Names
Chirhostim
Drug Type
Biotech
Chemical Formula
-
CAS Number
108153-74-8
Unique Ingredient Identifier
A0426J905J
Background

Human secretin is a gastrointestinal peptide hormone that regulates secretions in the stomach, pancreas, and liver. The hormone is produced from the enterochromaffin cells in the duodenum in response to the duodenal content with the pH less than 4.5 . The main action of secretin is to stimulate the pancreas to secrete pancreatic juice for pH regulation in the small intestines. Secretin is also responsible in body fluid homeostasis and bile production. Although it is a gastrointestinal hormone, secretin is also considered as a neuropeptide hormone since it is also expressed in the central nervous system .

Purified synthetic human secretin, also referred to as RG1068, is available as an intravenous injection under the market name ChiRhoStim ® in the U.S.. It contains an amino acid sequence identical to the naturally occurring hormone consisting of 27 amino acids that supports α-helical formation . The carboxyl-terminal amino acid, valine, is amidated. Synthetic human secretin displays equivalent biological activity and properties as naturally-occurring secretin . It is indicated for the stimulation of the pancreatic and gastric secretions to aid in the diagnosis of pancreatic exocrine dysfunction and the diagnosis of gastrinoma, and facilitate the identification of the ampulla of Vater and accessory papilla during endoscopic retrograde cholangiopancreatography (ERCP).

Indication

Indicated for the stimulation of:

Associated Conditions
Gastrinoma, Pancreatic exocrine dysfunction
Associated Therapies
-

Secretin Infusion to Prevent Pancreatic Leaks Following Pancreatic Resection

Phase 2
Completed
Conditions
Interventions
First Posted Date
2014-06-11
Last Posted Date
2020-03-31
Lead Sponsor
Dartmouth-Hitchcock Medical Center
Target Recruit Count
170
Registration Number
NCT02160808
Locations
🇺🇸

Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire, United States

The Cancer of the Pancreas Screening-5 CAPS5)Study

First Posted Date
2013-12-03
Last Posted Date
2024-11-21
Lead Sponsor
Johns Hopkins University
Target Recruit Count
9000
Registration Number
NCT02000089
Locations
🇺🇸

Yale University, New Haven, Connecticut, United States

🇺🇸

Johns Hopkins Hospital, Baltimore, Maryland, United States

🇺🇸

Dana Farber Cancer Center, Harvard University, Boston, Massachusetts, United States

and more 5 locations

Non-invasive MRI to Quantify the Effect of Secretin on Pancreatic Blood Flow and Perfusion in Healthy Volunteers

Phase 1
Completed
Conditions
Interventions
First Posted Date
2011-10-14
Last Posted Date
2011-10-14
Lead Sponsor
University of Nottingham
Target Recruit Count
12
Registration Number
NCT01452217
Locations
🇬🇧

University of Nottingham, Nottingham, Nottinghamshire, United Kingdom

Secretin Infusion for Pain Due to Chronic Pancreatitis

Phase 1
Completed
Conditions
Interventions
First Posted Date
2010-12-23
Last Posted Date
2016-03-09
Lead Sponsor
ChiRhoClin, Inc.
Target Recruit Count
12
Registration Number
NCT01265875
Locations
🇺🇸

Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire, United States

A Study of Serial Magnetic Resonance Cholangiopancreatography (MRCP) Following Morphine-neostigmine and Secretin Provocation in Healthy Volunteers

First Posted Date
2010-06-02
Last Posted Date
2010-06-02
Lead Sponsor
University of Nottingham
Target Recruit Count
10
Registration Number
NCT01134848
Locations
🇬🇧

University of Nottingham, Nottingham, Nottinghamshire, United Kingdom

Secretin-Stimulated Magnetic Resonance Cholangiopancreatography (S-MRCP) in Pancreatic Patients

First Posted Date
2010-03-29
Last Posted Date
2016-09-09
Lead Sponsor
Elizabeth Hecht
Target Recruit Count
23
Registration Number
NCT01094561
Locations
🇺🇸

Columbia University Medical Center, New York, New York, United States

Secretin-enhanced Magnetic Resonance Cholangiopancreatography (S-MRCP) and Pancreatic Function Following Surgery

Not Applicable
Withdrawn
Conditions
Interventions
First Posted Date
2010-03-29
Last Posted Date
2015-04-06
Lead Sponsor
Columbia University
Registration Number
NCT01094535
Locations
🇺🇸

Columbia University Medical Center, New York, New York, United States

Secretin-enhanced Magnetic Resonance Imaging (S-MRI) for Pancreatic Cancer Detection

First Posted Date
2010-03-29
Last Posted Date
2016-06-10
Lead Sponsor
Elizabeth Hecht
Registration Number
NCT01094626

A Study of Synthetic Human Secretin (ChiRhoStim®) Administered Intravenously to Stimulate Exocrine Pancreas Fluid Secretion for Collection Via Endoscope and Laboratory Analysis of DNA Markers

Phase 3
Completed
Conditions
Interventions
First Posted Date
2010-03-16
Last Posted Date
2011-12-06
Lead Sponsor
ChiRhoClin, Inc.
Target Recruit Count
64
Registration Number
NCT01087801
Locations
🇺🇸

Saint Louis University, Saint Louis, Missouri, United States

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