Secretin human

Generic Name
Secretin human
Brand Names
Chirhostim
Drug Type
Biotech
Chemical Formula
-
CAS Number
108153-74-8
Unique Ingredient Identifier
A0426J905J
Background

Human secretin is a gastrointestinal peptide hormone that regulates secretions in the stomach, pancreas, and liver. The hormone is produced from the enterochromaffin cells in the duodenum in response to the duodenal content with the pH less than 4.5 . The main action of secretin is to stimulate the pancreas to secrete pancreatic juice for pH regulation in the small intestines. Secretin is also responsible in body fluid homeostasis and bile production. Although it is a gastrointestinal hormone, secretin is also considered as a neuropeptide hormone since it is also expressed in the central nervous system .

Purified synthetic human secretin, also referred to as RG1068, is available as an intravenous injection under the market name ChiRhoStim ® in the U.S.. It contains an amino acid sequence identical to the naturally occurring hormone consisting of 27 amino acids that supports α-helical formation . The carboxyl-terminal amino acid, valine, is amidated. Synthetic human secretin displays equivalent biological activity and properties as naturally-occurring secretin . It is indicated for the stimulation of the pancreatic and gastric secretions to aid in the diagnosis of pancreatic exocrine dysfunction and the diagnosis of gastrinoma, and facilitate the identification of the ampulla of Vater and accessory papilla during endoscopic retrograde cholangiopancreatography (ERCP).

Indication

Indicated for the stimulation of:

Associated Conditions
Gastrinoma, Pancreatic exocrine dysfunction
Associated Therapies
-

The Role of Secretin on the Energy Homeostasis

Not Applicable
Completed
Conditions
Interventions
First Posted Date
2020-11-03
Last Posted Date
2020-11-05
Lead Sponsor
Steno Diabetes Center Copenhagen
Target Recruit Count
25
Registration Number
NCT04613700
Locations
🇩🇰

Herlev- Gentofte Hospital, Center for Clinical Metabolic Research, Hellerup, Copenhagen, Denmark

Recurrent Abdominal Pain and Exocrine Pancreatic Insufficiency

First Posted Date
2020-01-18
Last Posted Date
2024-04-03
Lead Sponsor
Orlando Health, Inc.
Target Recruit Count
27
Registration Number
NCT04231279
Locations
🇺🇸

Orlando Health - Arnold Palmer Children's Hospital, Orlando, Florida, United States

Secretin for Acute Pancreatitis

Phase 2
Conditions
Interventions
First Posted Date
2018-09-27
Last Posted Date
2019-04-10
Lead Sponsor
ChiRhoClin, Inc.
Target Recruit Count
40
Registration Number
NCT03686618
Locations
🇺🇸

Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire, United States

Effect of Secretin in Functional Dyspepsia and Healthy Subjects

Phase 1
Completed
Conditions
Interventions
First Posted Date
2018-08-07
Last Posted Date
2020-06-11
Lead Sponsor
Mayo Clinic
Target Recruit Count
20
Registration Number
NCT03617861
Locations
🇺🇸

Mayo Clinic in Rochester, Rochester, Minnesota, United States

Optical and Biochemical Biomarkers in Early Pancreatic Cancer

Completed
Conditions
Interventions
First Posted Date
2018-01-19
Last Posted Date
2023-06-06
Lead Sponsor
Mayo Clinic
Target Recruit Count
346
Registration Number
NCT03404661
Locations
🇺🇸

Mayo Clinic in Florida, Jacksonville, Florida, United States

Secretin Activates Human Brown Fat and Induces Satiation.

First Posted Date
2017-09-25
Last Posted Date
2019-12-23
Lead Sponsor
Turku University Hospital
Target Recruit Count
23
Registration Number
NCT03290846
Locations
🇫🇮

Turku PET Centre, Turku, Finland

MRCP: A Reliable, Non Invasive Method for Staging Chronic Pancreatitis in Pediatrics

Not Applicable
Completed
Conditions
Interventions
First Posted Date
2016-08-17
Last Posted Date
2020-08-07
Lead Sponsor
Children's Hospital Medical Center, Cincinnati
Target Recruit Count
57
Registration Number
NCT02869893
Locations
🇺🇸

Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States

Pancreatic Perfusion Using Secretin and MRI

Phase 1
Conditions
Interventions
First Posted Date
2015-05-29
Last Posted Date
2016-02-18
Lead Sponsor
University of Nottingham
Target Recruit Count
15
Registration Number
NCT02458118
Locations
🇬🇧

1.5T Brain and Body Imaging centre, University of Nottingham Campus, Nottingham, Nottinghamshire, United Kingdom

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