Methylprednisolone hemisuccinate

Generic Name: Methylprednisolone hemisuccinate

Brand Names: Solu-medrol

Drug Type: Small Molecule

Chemical Formula: C_₂₆H_₃₄O_₈

CAS Number: 2921-57-5

Unique Ingredient Identifier: 5GMR90S4KN

Background: A water-soluble ester of methylprednisolone used for cardiac, allergic, and hypoxic emergencies.

Associated Conditions: Acute Gouty Arthritis, Ankylosing Spondylitis (AS), Berylliosis, Congenital Adrenal Hyperplasia (CAH), Congenital Hypoplastic Anemia, Dermatitis bullous, Dermatomyositis (DM), Edema of the cerebrum, Hypercalcemia of Malignancy, Immune Thrombocytopenia (ITP), Leukemias, Lymphoma, Multiple sclerosis exacerbation, Mycosis Fungoides (MF), Ophthalmia, Sympathetic, Pemphigus, Polymyositis, Primary adrenocortical insufficiency, Psoriatic Arthritis, Pure Red Cell Aplasia, Refractory Uveitis, Regional Enteritis, Rheumatoid Arthritis, Secondary adrenocortical insufficiency, Secondary thrombocytopenia, Stevens-Johnson Syndrome, Systemic Lupus Erythematosus, Temporal Arteritis, Trichinosis, Tuberculous Meningitis, Ulcerative Colitis, Acquired immune hemolytic anemia, Acute rheumatic carditis, Disseminated Pulmonary Tuberculosis (TB), Exfoliative erythroderma, Fulminating Pulmonary Tuberculosis, Idiopathic eosinophilic pneumonias, Non-suppurative Thyroiditis, Severe Allergic Reactions, Symptomatic Sarcoidosis

Associated Therapies: Palliative Treatment

Clinical Trials

Corticosteroid Therapy in Neonates Undergoing Cardiopulmonary Bypass

Not Applicable

Completed

Conditions: Congenital Heart Disease
Disorder of Fetus or Newborn

Interventions: Drug: Placebo
Drug: Methylprednisolone

First Posted Date: 2012-04-18

Last Posted Date: 2019-12-09

Lead Sponsor: Medical University of South Carolina

Target Recruit Count: 190

Registration Number: NCT01579513

Locations: 🇺🇸
Children's Healthcare of Atlanta/Emory University, Atlanta, Georgia, United States
🇺🇸
Medical University of South Carolina, Pediatric Cardiology, Charleston, South Carolina, United States

The Effect of Intravenous Glucocorticoids on the Tearfilm in Eyes With Thyroid-associated Ophthalmopathy

Phase 3

Completed

Conditions: Thyroid-associated Ophthalmopathy
Dry Eye Syndrome

Interventions: Drug: Methylprednisolone
Drug: Esomeprazole

First Posted Date: 2012-04-18

Last Posted Date: 2020-02-20

Lead Sponsor: Medical University of Vienna

Target Recruit Count: 18

Registration Number: NCT01579539

Locations: 🇦🇹
Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria

Therapeutic Evaluation of Steroids in IgA Nephropathy Global Study (TESTING Low Dose Study)

Not Applicable

Completed

Conditions: IgA Glomerulonephritis

Interventions: Drug: Placebo
Drug: methylprednisolone

First Posted Date: 2012-03-21

Last Posted Date: 2021-09-23

Lead Sponsor: The George Institute

Target Recruit Count: 503

Registration Number: NCT01560052

Locations: 🇦🇺
Concord Repatriation and General Hospital, Concord, New South Wales, Australia
🇦🇺
Nepean Hospital, Kingswood, New South Wales, Australia
🇦🇺
Royal North Shore Hospital, St Leonards, New South Wales, Australia

and more 63 locations

Epidural Steroid Following Discectomy for Herniated Disc Reduces Morbidity

Not Applicable

Completed

Conditions: Disc Disease

Interventions: Drug: Methylprednisolone

First Posted Date: 2011-12-26

Last Posted Date: 2014-09-15

Lead Sponsor: Northern Orthopaedic Division, Denmark

Target Recruit Count: 200

Registration Number: NCT01499641

Locations: 🇩🇰
Department of Orthopaedic Surgery, Vejle and Give Hospital, Vejle, Denmark
🇩🇰
Orthopaedic Surgery Research Unit, Aalborg University Hospital, Aalborg, Denmark
🇩🇰
Section for Surgical Pathophysiology, Juliane Marie Centre, Rigshospitalet, Copenhagen, Denmark

Autologous Stem Cell Systemic Sclerosis Immune Suppression Trial

Phase 3

Terminated

Conditions: Scleroderma, Systemic

Interventions: Biological: Peripheral Blood Stem Cells
Drug: Cyclophosphamide
Drug: Mesna
Drug: rATG
Drug: Methylprednisolone
Drug: Filgrastim
Drug: Fludarabine

First Posted Date: 2011-10-04

Last Posted Date: 2020-07-23

Lead Sponsor: Northwestern University

Target Recruit Count: 44

Registration Number: NCT01445821

Locations: 🇺🇸
Northwestern University, Chicago, Illinois, United States

Optimization of NULOJIX® Usage As A Means of Avoiding CNI and Steroids in Renal Transplantation

Phase 2

Terminated

Conditions: Kidney Transplantation
Renal Transplantation

Interventions: Drug: Alemtuzumab
Drug: MMF
Biological: Basiliximab
Biological: Belatacept
Drug: Short-term Tac
Drug: tacrolimus
Drug: methylprednisolone

First Posted Date: 2011-09-19

Last Posted Date: 2017-09-27

Lead Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Target Recruit Count: 19

Registration Number: NCT01436305

Locations: 🇺🇸
University of Alabama, Birmingham, Alabama, United States
🇺🇸
Emory University, Atlanta, Georgia, United States
🇺🇸
University of California San Francisco, San Francisco, California, United States