MedPath

Zinc

Generic Name
Zinc
Brand Names
Vitafol-one, Wilzin
Drug Type
Small Molecule
Chemical Formula
Zn
CAS Number
7440-66-6
Unique Ingredient Identifier
J41CSQ7QDS
Background

A metallic element of atomic number 30 and atomic weight 65.38. It is a necessary trace element in the diet, forming an essential part of many enzymes, and playing an important role in protein synthesis and in cell division. Zinc deficiency is associated with anemia, short stature, hypogonadism, impaired wound healing, and geophagia. It is identified by the symbol Zn .

A newer study suggests implies that an imbalance of zinc is associated with the neuronal damage associated with traumatic brain injury, stroke, and seizures .

Understanding the mechanisms that control brain zinc homeostasis is, therefore, imperative to the development of preventive and treatment regimens for these and other neurological disorders .

In addition to the above, recent review articles have already demonstrated the important role of zinc in the pathophysiology and treatment of affective disorders, plus discussed the potential value of zinc as a marker of these diseases . Most recently, research has shown that polymorphism of the common polymorphism in zinc transporter SLC30A8/ZnT8 may increase susceptibility to type 2 diabetes provided novel insights into the role of zinc in diabetes .

Indication

Zinc can be used for the treatment and prevention of zinc deficiency/its consequences, including stunted growth and acute diarrhea in children, and slowed wound healing. It is also utilized for boosting the immune system, treating the common cold and recurrent ear infections, as well as preventing lower respiratory tract infections .

Associated Conditions
Candidiasis, Common Cold, Diaper Dermatitis, Diaper Rash, Eye redness, Iron Deficiency (ID), Ocular Irritation, Skin Irritation, Sunburn, Wilson's Disease, Zinc Deficiency
Associated Therapies
Dietary and Nutritional Therapies, Dietary supplementation

Zinc Sulfate Acceptability

First Posted Date
2019-07-31
Last Posted Date
2021-02-05
Lead Sponsor
International Centre for Diarrhoeal Disease Research, Bangladesh
Target Recruit Count
325
Registration Number
NCT04039828
Locations
🇧🇩

International centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh

🇧🇩

Dhaka Hospital, Dhaka, Bangladesh

Thinking Zinc: a Study of Zinc Supplements on the Navajo Nation

Not Applicable
Recruiting
Conditions
DNA Damage
Immune System Disorder
Interventions
First Posted Date
2019-04-09
Last Posted Date
2025-05-20
Lead Sponsor
University of New Mexico
Target Recruit Count
100
Registration Number
NCT03908736
Locations
🇺🇸

University of New Mexico Health Sciences Center, Albuquerque, New Mexico, United States

Zinc Supplementation in Patients With β-Thalassemia Major Complicated With Diabetes Mellitus

Phase 3
Completed
Conditions
Beta-thalassemia Major Complicated With Diabetes
Interventions
First Posted Date
2019-02-22
Last Posted Date
2019-02-25
Lead Sponsor
Ain Shams University
Target Recruit Count
80
Registration Number
NCT03851055
Locations
🇪🇬

Nancy Elbarbary, Cairo, Egypt

Efficacy of Zinc on Concurrent Chemo-radiotherapy Induced Taste Alterations

Phase 3
Completed
Conditions
Taste, Altered
Interventions
Drug: Placebo oral Zinc capsule
First Posted Date
2019-01-31
Last Posted Date
2019-01-31
Lead Sponsor
Dow University of Health Sciences
Target Recruit Count
70
Registration Number
NCT03824925
Locations
🇵🇰

Dow University of Health Sciences, Karachi, Sindh, Pakistan

Zinc as Enhancer in Immune Recovery After Stem Cell Transplantation for Hematological Malignancies

First Posted Date
2017-05-19
Last Posted Date
2020-01-07
Lead Sponsor
Azienda Ospedaliero, Universitaria Pisana
Target Recruit Count
20
Registration Number
NCT03159845
Locations
🇮🇹

Hematology UO, Pisa, Italy

Pilot of Zinc Acetate to Improve Chronic Cough

Phase 2
Completed
Conditions
Cough
Interventions
Drug: Placebo oral capsule
First Posted Date
2017-05-01
Last Posted Date
2021-01-20
Lead Sponsor
Johns Hopkins University
Target Recruit Count
34
Registration Number
NCT03135522
Locations
🇺🇸

National Jewish Medical and Research Center, Denver, Colorado, United States

🇺🇸

Washington University School of Medicine, Saint Louis, Missouri, United States

🇺🇸

Mount Sinai School of Medicine, New York, New York, United States

and more 2 locations

Effect of SLC30A8 rs13266634 Genetic Polymorphism on Zinc Supplementation and Glycemic Control in Egyptian Patients With Type 2 Diabetes Mellitus

Phase 4
Completed
Conditions
Diabetes Mellitus, Type II
Interventions
First Posted Date
2017-04-13
Last Posted Date
2017-08-08
Lead Sponsor
Cairo University
Target Recruit Count
80
Registration Number
NCT03112382
Locations
🇪🇬

theoutpatient clinics, department of internal medicine, Cairo University teaching hospitals,, Cairo, Egypt

The Effect of Zinc, β-carotene, and Vitamin D3 in Preterm Delivery Through Placental MyD88, TRIF, NFkB, and IL-1β

First Posted Date
2016-12-29
Last Posted Date
2017-11-21
Lead Sponsor
Indonesia University
Target Recruit Count
56
Registration Number
NCT03005496

Effects of IV-Administered Ca-DTPA and Zn-DTPA To Treat Patients With Gadolinium Deposition Disease

Phase 1
Terminated
Conditions
Headache
Arthralgia
Cognitive Disturbance
Skin Hyperpigmentation
Interventions
First Posted Date
2016-10-27
Last Posted Date
2018-04-06
Lead Sponsor
University of North Carolina, Chapel Hill
Target Recruit Count
1
Registration Number
NCT02947022
Locations
🇺🇸

UNC Hospitals, Chapel Hill, North Carolina, United States

Package of Interventions After Recovering From Moderate Acute Malnutrition

Not Applicable
Completed
Conditions
Malnutrition
Interventions
Dietary Supplement: Lipid Nutrient Supplement
Other: Insecticide-treated bednet
First Posted Date
2015-01-30
Last Posted Date
2016-11-10
Lead Sponsor
Washington University School of Medicine
Target Recruit Count
1499
Registration Number
NCT02351687
Locations
🇲🇼

St. Louis Nutrition Project, Blantyre, Malawi

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