Tiotropium
- Generic Name
- Tiotropium
- Brand Names
- Inspiolto Respimat, Spiriva, Spiriva Respimat, Stiolto
- Drug Type
- Small Molecule
- Chemical Formula
- C19H22NO4S2
- CAS Number
- 186691-13-4
- Unique Ingredient Identifier
- 0EB439235F
- Background
Tiotropium is a long-acting, antimuscarinic bronchodilator used in the management of chronic obstructive pulmonary disease (COPD) and asthma. Tiotropium acts mainly on M3 muscarinic receptors located in the airways to produce smooth muscle relaxation and bronchodilation.
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- Indication
Tiotropium powder for inhalation is indicated for the maintenance of bronchospasm in COPD and to prevent exacerbations of COPD. A combination tiotropium and olodaterol metered inhalation spray is indicated for maintenance of COPD. A tiotropium inhalation spray is indicated for the maintenance of bronchospasm in COPD, to prevent exacerbations of COPD, and to ...
- Associated Conditions
- Asthma, Bronchitis, Bronchoconstriction, Chronic Bronchitis, Chronic Obstructive Pulmonary Disease (COPD), Emphysema, Exacerbation of COPD
- Associated Therapies
- -
A Randomized Study, Comparing Fluticasone Furoate/Umeclidinium/Vilanterol (FF/UMEC /VI) Single Inhaler Triple Therapy, Versus Multiple Inhaler Therapy (Budesonide/Formoterol Plus Tiotropium) in Subjects With Chronic Obstructive Pulmonary Disease (COPD)
- Conditions
- Interventions
- First Posted Date
- 2018-03-27
- Last Posted Date
- 2020-10-28
- Lead Sponsor
- GlaxoSmithKline
- Target Recruit Count
- 732
- Registration Number
- NCT03478696
- Locations
- 🇩🇪
GSK Investigational Site, Leipzig, Germany
A Comparative Study Between Fluticasone Furoate/Umeclidinium/Vilanterol (FF/UMEC/VI) Single Inhaler Triple Therapy Versus Tiotropium Monotherapy in Subjects With Chronic Obstructive Pulmonary Disease (COPD)
- First Posted Date
- 2018-03-22
- Last Posted Date
- 2021-07-15
- Lead Sponsor
- GlaxoSmithKline
- Target Recruit Count
- 800
- Registration Number
- NCT03474081
- Locations
- 🇷🇺
GSK Investigational Site, Voronezh, Russian Federation
Effectiveness of Fluticasone Furoate/ Umeclidinium/ Vilanterol (FF/UMEC/VI) Using the Connected Inhaler System (CIS) as Compared With Fluticasone Proprionate/ Salmeterol (FP/SAL) Plus Tiotropium (TIO) in Inadequately Controlled Asthma
- First Posted Date
- 2017-12-19
- Last Posted Date
- 2019-03-25
- Lead Sponsor
- GlaxoSmithKline
- Registration Number
- NCT03376932
Comparison of the Pharmacokinetics of Tiotropium Delivered From Test Inhaler Products With Reference
- First Posted Date
- 2017-10-04
- Last Posted Date
- 2024-12-02
- Lead Sponsor
- Solventum US LLC
- Target Recruit Count
- 38
- Registration Number
- NCT03302065
Efficiency of Twice Daily Formoterol Versus Once Daily Tiotropium in Patients With GOLD A/B COPD
- Conditions
- Interventions
- First Posted Date
- 2017-08-23
- Last Posted Date
- 2017-10-19
- Lead Sponsor
- Huashan Hospital
- Target Recruit Count
- 120
- Registration Number
- NCT03258749
- Locations
- 🇨🇳
Huashan hospital,Fudan university, Shanghai, Shanghai, China
Two-period 21 Day Cross-over Study to Compare the Pharmacokinetics of Tiotropium From Two Inhalers
- First Posted Date
- 2017-08-11
- Last Posted Date
- 2024-12-02
- Lead Sponsor
- Solventum US LLC
- Target Recruit Count
- 40
- Registration Number
- NCT03246581
- Locations
- 🇬🇧
3M Health Care, Loughborough, United Kingdom
The ENERGITO® 2 Study Compares 2 Inhaled Medicines for Chronic Obstructive Pulmonary Disease (COPD). One Medicine is a Combination of Tiotropium and Olodaterol (Stiolto®) Taken Using the Respimat® Inhaler and the Other Medicine is a Combination of Fluticasone and Salmeterol Taken Using the Diskus
- Conditions
- Interventions
- First Posted Date
- 2017-08-07
- Last Posted Date
- 2020-04-16
- Lead Sponsor
- Boehringer Ingelheim
- Target Recruit Count
- 302
- Registration Number
- NCT03240575
- Locations
- 🇺🇸
Pulmonary Rsrch Inst of SE MI, Farmington Hills, Michigan, United States
🇺🇸Spartanburg Medical Research, Spartanburg, South Carolina, United States
🇺🇸Johns Hopkins Hospital, Baltimore, Maryland, United States
Specific Use-Result of Spiriva Respimat® in Asthmatics
- First Posted Date
- 2017-06-15
- Last Posted Date
- 2019-11-27
- Lead Sponsor
- Boehringer Ingelheim
- Target Recruit Count
- 193
- Registration Number
- NCT03188120
- Locations
- 🇯🇵
Nippon Boehringer Ingelheim Co., Ltd, Tokyo, Japan
PET Study to Determine Muscarinic Receptor Occupancy in Lungs After Inhalation of AZD2115 and Tiotropium
- Conditions
- Interventions
- First Posted Date
- 2017-03-31
- Last Posted Date
- 2021-08-30
- Lead Sponsor
- AstraZeneca
- Target Recruit Count
- 19
- Registration Number
- NCT03097380
- Locations
- 🇸🇪
Research Site, Stockholm, Sweden
Cardiovascular Function in COPD Patients
- Conditions
- Interventions
- First Posted Date
- 2017-02-16
- Last Posted Date
- 2019-08-16
- Lead Sponsor
- Boehringer Ingelheim
- Target Recruit Count
- 76
- Registration Number
- NCT03055988
- Locations
- 🇩🇪
Universitätsklinikum Bonn AöR, Bonn, Germany
🇩🇪Klinische Forschung Berlin GbR, Berlin, Germany
🇩🇪Praxis Dr. med. Claus Keller, Frankfurt, Germany
Drug Development Updates
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