Dextromethorphan

Generic Name: Dextromethorphan

Brand Names: Auvelity, Benylin DM, Bromfed DM, Broncotron, Cepacol Sore Throat Plus Cough, Cheracol D, Children's Nyquil Cold and Cough, Chloraseptic Sore Throat + Cough, Coricidin Hbp Chest Congestion, Coricidin Hbp Cough and Cold, Creomulsion, DM, Dayquil Cough, Delsym, Delsym Cough Plus Chest Congestion DM, Delsym Cough Plus Soothing Action, Delsym Cough Relief Plus Soothing Action, Despec Reformulated Jun 2008, Diabetic Tussin DM, Dimetapp Long Acting Cough Plus Cold, Diphen, G-zyncof, Mucinex Children's Cough, Mucinex Cough, Mucinex DM, Nuedexta, Nyquil Cough, Pediacare Children's Cough and Congestion, Promethazine DM, Robafen Cough, Robafen DM, Robitussin 12 Hour Cough Relief, Robitussin Cough & Congestion, Robitussin Maximum Strength Cough Plus Chest Congestion DM, Robitussin Nighttime Cough DM, Robitussin Pediatric Cough & Cold LA, Robitussin Pediatric Cough Suppressant, Safetussin DM, Safetussin PM, Scot-tussin DM, Scot-tussin Diabetic CF, Scot-tussin Sugar Free DM, Sudafed PE Children's Cold & Cough, Triaminic Day Time Cold & Cough, Tusnel Diabetic

Drug Type: Small Molecule

Chemical Formula: C_₁₈H_₂₅NO

CAS Number: 125-71-3

Unique Ingredient Identifier: 7355X3ROTS

Background: Dextromethorphan is a levorphanol derivative and codeine analog commonly used as a cough suppressant and also a drug of abuse. Although similar in structure to other opioids, it has minimal interaction with opioid receptors.

Dextromethorphan was granted FDA approval before 3 December 1957.

Indication: Dextromethorphan is indicated in combination with brompheniramine and pseudoephedrine in the treatment of coughs and upper respiratory symptoms associated with allergies or the common cold. Dextromethorphan is also used in combination with guaifenesin as an over-the-counter product to relieve a cough. Dextromethorphan in combination with quinidine is indicated in the treatment of pseudobulbar affect.

Associated Conditions: Allergic cough, Common Cold, Cough, Cough caused by Common Cold, Coughing caused by Allergies, Coughing caused by Bronchitis, Coughing caused by Flu caused by Influenza, Fever, Flu caused by Influenza, Headache, Irritative cough, Itching of the nose, Itching of the throat, Major Depressive Disorder (MDD), Nasal Congestion, Pseudobulbar Affect (PBA), Rhinorrhoea, Sneezing, Cold or flu syndrome, Upper respiratory symptoms, Watery itchy eyes

Associated Therapies: Airway secretion clearance therapy, Bronchodilation, Oropharyngeal antisepsis

Clinical Trials

Study to Investigate Safety With Special Emphasis on ECG Effects and Tolerability After Oral Doses of Dextromethorphan Hydrobromide Monohydrate in Healthy Male and Female Subjects

Phase 1

Completed

Conditions: Healthy

Interventions: Drug: Dextromethorphan syrup - high dose
Drug: Dextromethorphan syrup - low dose
Drug: Placebo

First Posted Date: 2014-07-16

Last Posted Date: 2014-07-16

Lead Sponsor: Boehringer Ingelheim

Target Recruit Count: 48

Registration Number: NCT02191176

Effects of BI 201335 NA on Cytochrome P450 and P-glycoprotein Activity Using a Probe Drug Cocktail in Healthy Volunteers

Phase 1

Completed

Conditions: Healthy

Interventions: Drug: BI 201335 NA
Drug: Caffeine
Drug: Warfarin sodium
Drug: Vitamin K
Drug: Omeprazole
Drug: Dextromethorphan hydrobromide
Drug: Midazolam HCl solution
Drug: Midazolam HCl oral syrup
Drug: Digoxin

First Posted Date: 2014-07-08

Last Posted Date: 2014-07-18

Lead Sponsor: Boehringer Ingelheim

Target Recruit Count: 23

Registration Number: NCT02182336

Nuedexta for the Prevention and Modification of Disease Progression in Episodic Migraine

Phase 2

Completed

Conditions: Episodic Migraine

Interventions: Drug: Dextromethorphan and quinidine
Drug: Placebo

First Posted Date: 2014-06-26

Last Posted Date: 2018-04-03

Lead Sponsor: Cady, Roger, M.D.

Target Recruit Count: 76

Registration Number: NCT02176018

Locations: 🇺🇸
Swedish American Neuro and Headache Center, Rockford, Illinois, United States
🇺🇸
StudyMetrix Research, LLC, Saint Peters, Missouri, United States
🇺🇸
Island Neurological Associates, PC, Plainview, New York, United States

and more 2 locations

Histamine Glutamate Antagonism in Stroke

Phase 2

Completed

Conditions: Acute Cerebrovascular Accident
Cerebral Edema

Interventions: Drug: Pantoprazole
Drug: Diphenhydramine
Drug: Famotidine
Drug: Dextromethorphan

First Posted Date: 2014-05-20

Last Posted Date: 2015-12-15

Lead Sponsor: University of Florida

Target Recruit Count: 3

Registration Number: NCT02142712

Locations: 🇺🇸
Shands Hospital at University of Florida, Gainesville, Florida, United States

Antitussive Effect of a Naturally Flavored Syrup Containing Diphenhydramine, Compared With Dextromethorphan and Placebo

Phase 4

Completed

Conditions: Cough Reflex Sensitivity

Interventions: Drug: diphenhydramine/phenylephrine/cocoa; dextromethorophan; placebo
Drug: diphenhydramine/phenylephrine/cocoa; placebo; dextromethorphan
Drug: dextromethorphan; diphenhydramine/phenylephrine/cocoa; placebo
Drug: dextromethorophan; placebo; diphenhydramine/phenylephrine/cocoa
Drug: placebo; diphenhydramine/phenylephrine/cocoa; dextromethorphan
Drug: placebo; dextromethorphan; diphenhydramine/phenylephrine/cocoa