Dextromethorphan

Generic Name: Dextromethorphan

Brand Names: Auvelity, Benylin DM, Bromfed DM, Broncotron, Cepacol Sore Throat Plus Cough, Cheracol D, Children's Nyquil Cold and Cough, Chloraseptic Sore Throat + Cough, Coricidin Hbp Chest Congestion, Coricidin Hbp Cough and Cold, Creomulsion, DM, Dayquil Cough, Delsym, Delsym Cough Plus Chest Congestion DM, Delsym Cough Plus Soothing Action, Delsym Cough Relief Plus Soothing Action, Despec Reformulated Jun 2008, Diabetic Tussin DM, Dimetapp Long Acting Cough Plus Cold, Diphen, G-zyncof, Mucinex Children's Cough, Mucinex Cough, Mucinex DM, Nuedexta, Nyquil Cough, Pediacare Children's Cough and Congestion, Promethazine DM, Robafen Cough, Robafen DM, Robitussin 12 Hour Cough Relief, Robitussin Cough & Congestion, Robitussin Maximum Strength Cough Plus Chest Congestion DM, Robitussin Nighttime Cough DM, Robitussin Pediatric Cough & Cold LA, Robitussin Pediatric Cough Suppressant, Safetussin DM, Safetussin PM, Scot-tussin DM, Scot-tussin Diabetic CF, Scot-tussin Sugar Free DM, Sudafed PE Children's Cold & Cough, Triaminic Day Time Cold & Cough, Tusnel Diabetic

Drug Type: Small Molecule

Chemical Formula: C_₁₈H_₂₅NO

CAS Number: 125-71-3

Unique Ingredient Identifier: 7355X3ROTS

Background: Dextromethorphan is a levorphanol derivative and codeine analog commonly used as a cough suppressant and also a drug of abuse. Although similar in structure to other opioids, it has minimal interaction with opioid receptors.

Dextromethorphan was granted FDA approval before 3 December 1957.

Indication: Dextromethorphan is indicated in combination with brompheniramine and pseudoephedrine in the treatment of coughs and upper respiratory symptoms associated with allergies or the common cold. Dextromethorphan is also used in combination with guaifenesin as an over-the-counter product to relieve a cough. Dextromethorphan in combination with quinidine is indicat...

Associated Conditions: Allergic cough, Common Cold, Cough, Cough caused by Common Cold, Coughing caused by Allergies, Coughing caused by Bronchitis, Coughing caused by Flu caused by Influenza, Fever, Flu caused by Influenza, Headache, Irritative cough, Itching of the nose, Itching of the throat, Major Depressive Disorder (MDD), Nasal Congestion, Pseudobulbar Affect (PBA), Rhinorrhoea, Sneezing, Cold or flu syndrome, Upper respiratory symptoms, Watery itchy eyes

Associated Therapies: Airway secretion clearance therapy, Bronchodilation, Oropharyngeal antisepsis

Clinical Trials

Interscalene Nerve Blocks With Ropivacaine Alone, With Dexamethasone, Plus Systemic Dexamethasone

Not Applicable

Terminated

Conditions: Pain

Interventions: Drug: Ropivacaine
Drug: dex
Drug: Saline
Drug: Bupivacaine

First Posted Date: 2007-08-22

Last Posted Date: 2017-07-21

Lead Sponsor: The Cleveland Clinic

Target Recruit Count: 218

Registration Number: NCT00519584

Locations: 🇺🇸
Cleveland Clinic Hillcrest, Cleveland, Ohio, United States
🇺🇸
Cleveland Clinic /Euclid Hospital, Euclid, Ohio, United States

Assessment of Opioid Analgesia in Sickle Cell

Phase 4

Withdrawn

Conditions: Sickle Cell Disease

Interventions: Drug: Dextromethorphan
Drug: Codeine
Drug: Morphine

First Posted Date: 2007-08-09

Last Posted Date: 2014-12-23

Lead Sponsor: Children's National Research Institute

Registration Number: NCT00513864

Locations: 🇺🇸
Children's National Medical Center, Washington, District of Columbia, United States

Study of Cobimetinib in Participants With Solid Tumors

Phase 1

Completed

Conditions: Solid Tumor

Interventions: Drug: cobimetinib
Drug: dextromethorphan
Drug: midazolam

First Posted Date: 2007-05-01

Last Posted Date: 2016-08-26

Lead Sponsor: Genentech, Inc.

Target Recruit Count: 119

Registration Number: NCT00467779

Pharmacokinetic Drug Interactions of AEGR-733 on Lipid-lowering Agents

Phase 2

Completed

Conditions: Healthy

First Posted Date: 2006-08-02

Last Posted Date: 2018-02-23

Lead Sponsor: Aegerion Pharmaceuticals, Inc.

Target Recruit Count: 125

Registration Number: NCT00359281

Locations: 🇺🇸
University of Pennsylvania, Philadelphia, Pennsylvania, United States

Hyperalgesia in Methadone Patients: Can it be Treated?

Phase 1

Conditions: Opioid-induced Hyperalgesia

First Posted Date: 2006-06-02

Last Posted Date: 2017-01-11

Lead Sponsor: National Institute on Drug Abuse (NIDA)

Target Recruit Count: 40

Registration Number: NCT00333242

Locations: 🇺🇸
UCLA School of Nursing, Los Angeles, California, United States

Hepatic Drug Biotransformation in Children With Obstructive Sleep Apnea

Not Applicable

Completed

Conditions: Sleep Apnea

Interventions: Drug: Dextromethorphan
Drug: Caffeine

First Posted Date: 2006-04-03

Last Posted Date: 2009-03-19

Lead Sponsor: Virginia Commonwealth University

Target Recruit Count: 69

Registration Number: NCT00310323

Locations: 🇺🇸
University of Louisville, Louisville, Kentucky, United States
🇺🇸
Virginia Commonwealth University, Richmond, Virginia, United States

Dextromethorphan in Treating Patients With Fatigue Caused by Cancer

Not Applicable

Terminated

Conditions: Fatigue
Unspecified Adult Solid Tumor, Protocol Specific
Unspecified Childhood Solid Tumor, Protocol Specific

First Posted Date: 2005-09-15

Last Posted Date: 2011-05-17

Lead Sponsor: University of Medicine and Dentistry of New Jersey

Target Recruit Count: 30

Registration Number: NCT00176540

Locations: 🇺🇸
Cancer Institute of New Jersey at UMDNJ - Robert Wood Johnson Medical School, New Brunswick, New Jersey, United States
🇺🇸
Cancer Institute of New Jersey at Hamilton, Hamilton, New Jersey, United States