Dextromethorphan
- Generic Name
- Dextromethorphan
- Brand Names
- Auvelity, Benylin DM, Bromfed DM, Broncotron, Cepacol Sore Throat Plus Cough, Cheracol D, Children's Nyquil Cold and Cough, Chloraseptic Sore Throat + Cough, Coricidin Hbp Chest Congestion, Coricidin Hbp Cough and Cold, Creomulsion, DM, Dayquil Cough, Delsym, Delsym Cough Plus Chest Congestion DM, Delsym Cough Plus Soothing Action, Delsym Cough Relief Plus Soothing Action, Despec Reformulated Jun 2008, Diabetic Tussin DM, Dimetapp Long Acting Cough Plus Cold, Diphen, G-zyncof, Mucinex Children's Cough, Mucinex Cough, Mucinex DM, Nuedexta, Nyquil Cough, Pediacare Children's Cough and Congestion, Promethazine DM, Robafen Cough, Robafen DM, Robitussin 12 Hour Cough Relief, Robitussin Cough & Congestion, Robitussin Maximum Strength Cough Plus Chest Congestion DM, Robitussin Nighttime Cough DM, Robitussin Pediatric Cough & Cold LA, Robitussin Pediatric Cough Suppressant, Safetussin DM, Safetussin PM, Scot-tussin DM, Scot-tussin Diabetic CF, Scot-tussin Sugar Free DM, Sudafed PE Children's Cold & Cough, Triaminic Day Time Cold & Cough, Tusnel Diabetic
- Drug Type
- Small Molecule
- Chemical Formula
- C18H25NO
- CAS Number
- 125-71-3
- Unique Ingredient Identifier
- 7355X3ROTS
- Background
Dextromethorphan is a levorphanol derivative and codeine analog commonly used as a cough suppressant and also a drug of abuse. Although similar in structure to other opioids, it has minimal interaction with opioid receptors.
Dextromethorphan was granted FDA approval before 3 December 1957.
- Indication
Dextromethorphan is indicated in combination with brompheniramine and pseudoephedrine in the treatment of coughs and upper respiratory symptoms associated with allergies or the common cold. Dextromethorphan is also used in combination with guaifenesin as an over-the-counter product to relieve a cough. Dextromethorphan in combination with quinidine is indicated in the treatment of pseudobulbar affect.
- Associated Conditions
- Allergic cough, Common Cold, Cough, Cough caused by Common Cold, Coughing caused by Allergies, Coughing caused by Bronchitis, Coughing caused by Flu caused by Influenza, Fever, Flu caused by Influenza, Headache, Irritative cough, Itching of the nose, Itching of the throat, Major Depressive Disorder (MDD), Nasal Congestion, Pseudobulbar Affect (PBA), Rhinorrhoea, Sneezing, Cold or flu syndrome, Upper respiratory symptoms, Watery itchy eyes
- Associated Therapies
- Airway secretion clearance therapy, Bronchodilation, Oropharyngeal antisepsis
Pilot Study Using an NMDA Antagonist to Modulate Transcranial Direct Current Stimulation (tDCS) Effects on Sensory Discrimination
- First Posted Date
- 2015-04-27
- Last Posted Date
- 2015-04-27
- Lead Sponsor
- University of Ottawa
- Target Recruit Count
- 12
- Registration Number
- NCT02426983
- Locations
- 🇨🇦
University of Ottawa Institute of Mental Health Research, Ottawa, Ontario, Canada
Pharmacokinetic Study to Evaluate the Effect of a Single Dose of Guselkumab (CNTO 1959) on CYP 450 Enzyme Activities After Subcutaneous Administration in Participants With Psoriasis
Phase 1
Completed
- Conditions
- Psoriasis
- Interventions
- First Posted Date
- 2015-03-25
- Last Posted Date
- 2017-09-20
- Lead Sponsor
- Janssen Research & Development, LLC
- Target Recruit Count
- 16
- Registration Number
- NCT02397382
Efficacy Study of Dextromethorphan to Treat Rheumatoid Arthritis
Not Applicable
Completed
- Conditions
- Rheumatoid Arthritis
- Interventions
- First Posted Date
- 2015-02-20
- Last Posted Date
- 2015-03-31
- Lead Sponsor
- Taichung Veterans General Hospital
- Target Recruit Count
- 48
- Registration Number
- NCT02368093
Dextromethorphan in Chemotherapy-induced Peripheral Neuropathy Management
Phase 2
Terminated
- Conditions
- Chemotherapy-induced Peripheral Neuropathy
- Interventions
- First Posted Date
- 2014-10-22
- Last Posted Date
- 2022-10-10
- Lead Sponsor
- University Hospital, Clermont-Ferrand
- Target Recruit Count
- 19
- Registration Number
- NCT02271893
- Locations
- 🇫🇷
Lise LACLAUTRE, Clermont-Ferrand, France
Study to Evaluate the Effect of Multiple Doses of BIRT 2584 XX Tablets on the Pharmacokinetic Parameters of Warfarin, Omeprazole, Caffeine, and Dextromethorphan in Healthy Male Volunteers
Phase 1
Completed
- Conditions
- Healthy
- Interventions
- First Posted Date
- 2014-10-06
- Last Posted Date
- 2014-10-06
- Lead Sponsor
- Boehringer Ingelheim
- Target Recruit Count
- 20
- Registration Number
- NCT02256813
Effects of Tipranavir (With Ritonavir) Capsule and Liquid Formulation on Cytochrome P450 and P-glycoprotein Activity in Healthy Volunteers
Phase 1
Completed
- Conditions
- Healthy
- Interventions
- First Posted Date
- 2014-09-18
- Last Posted Date
- 2014-09-18
- Lead Sponsor
- Boehringer Ingelheim
- Target Recruit Count
- 34
- Registration Number
- NCT02243553
A Study to Evaluate How Daily Dosing With Enzalutamide Affects the Metabolism of Caffeine and Dextromethorphan in Men With Prostate Cancer
Phase 1
Completed
- Conditions
- Prostate CancerPharmacokinetics of DextromethorphanPharmacokinetics of Caffeine
- Interventions
- First Posted Date
- 2014-08-26
- Last Posted Date
- 2017-06-27
- Lead Sponsor
- Astellas Pharma Europe B.V.
- Target Recruit Count
- 12
- Registration Number
- NCT02225093
- Locations
- 🇲🇩
Arensia, Chisinau, Moldova, Republic of
Clinical Neuropharmacology of Pain in Spinal Cord Injury- Dextromethorphan/Lidocaine Combination Clinical Trial
Phase 2
Completed
- Conditions
- Central Neuropathic PainAllodyniaSpinal Cord Injury
- Interventions
- First Posted Date
- 2014-08-18
- Last Posted Date
- 2018-03-22
- Lead Sponsor
- Brigham and Women's Hospital
- Target Recruit Count
- 26
- Registration Number
- NCT02218203
- Locations
- 🇺🇸
Translational Pain Research, Brigham and Women's Hospital, Boston, Massachusetts, United States
Trial of Naltrexone and Dextromethorphan for Gulf War Illness
- First Posted Date
- 2014-08-01
- Last Posted Date
- 2016-03-03
- Lead Sponsor
- East Carolina University
- Target Recruit Count
- 60
- Registration Number
- NCT02206490
- Locations
- 🇺🇸
Brody School of Medicine a East Carolina Univesity, Greenville, North Carolina, United States
Relative Bioavailability of Dextromethorphan Syrup in Comparison to Dextromethorphan Soft Pastilles in Healthy Male and Female Subjects
Phase 1
Completed
- Conditions
- Healthy
- Interventions
- First Posted Date
- 2014-07-16
- Last Posted Date
- 2014-07-16
- Lead Sponsor
- Boehringer Ingelheim
- Target Recruit Count
- 18
- Registration Number
- NCT02191709
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