Dapsone
- Generic Name
- Dapsone
- Brand Names
- Aczone
- Drug Type
- Small Molecule
- Chemical Formula
- C12H12N2O2S
- CAS Number
- 80-08-0
- Unique Ingredient Identifier
- 8W5C518302
- Background
A sulfone active against a wide range of bacteria but mainly employed for its actions against mycobacterium leprae. Its mechanism of action is probably similar to that of the sulfonamides which involves inhibition of folic acid synthesis in susceptible organisms. It is also used with pyrimethamine in the treatment of malaria. (From Martindale, The Extra Pharmacopoeia, 30th ed, p157-8)
- Indication
For the treatment and management of leprosy and dermatitis herpetiformis.
- Associated Conditions
- Acne Vulgaris, Bullous Systemic Lupus Erythematosus, Bullous dermatitis herpetiformis, Hansen's Disease, Pemphigus Vulgaris (PV), Relapsing Polychondritis, Mild Pneumocystis pneumonia, Mild Toxoplasma gondii encephalitis, Moderate Pneumocystis pneumonia, Moderate Toxoplasma gondii encephalitis, Refractory Idiopathic thrombocytopenic purpura
A Randomized, Comparative Study of Daily Dapsone and Daily Atovaquone for Prophylaxis Against PCP in HIV-Infected Patients Who Are Intolerant of Trimethoprim and/or Sulfonamides
- Conditions
- Pneumonia, Pneumocystis CariniiHIV Infections
- First Posted Date
- 2001-08-31
- Last Posted Date
- 2021-11-04
- Target Recruit Count
- 700
- Registration Number
- NCT00000802
- Locations
- 🇺🇸
Case CRS, Cleveland, Ohio, United States
🇺🇸Ucsd, Avrc Crs, San Diego, California, United States
🇺🇸Univ. of Miami AIDS CRS, Miami, Florida, United States
A Study of Pentamidine Plus Dapsone in the Prevention of Pneumocystis Carinii Pneumonia (PCP) in HIV-Infected Patients Who Cannot Take Trimethoprim or Sulfonamides
- Conditions
- Pneumonia, Pneumocystis CariniiHIV Infections
- First Posted Date
- 2001-08-31
- Last Posted Date
- 2021-11-01
- Target Recruit Count
- 400
- Registration Number
- NCT00001028
- Locations
- 🇺🇸
Community Consortium of San Francisco, San Francisco, California, United States
🇺🇸Denver CPCRA / Denver Public Hlth, Denver, Colorado, United States
🇺🇸Wilmington Hosp / Med Ctr of Delaware, Wilmington, Delaware, United States
Diffuse Fibrotic Lung Disease
- Conditions
- Pulmonary FibrosisSarcoidosisLung Diseases
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