Dapsone
- Generic Name
- Dapsone
- Brand Names
- Aczone
- Drug Type
- Small Molecule
- Chemical Formula
- C12H12N2O2S
- CAS Number
- 80-08-0
- Unique Ingredient Identifier
- 8W5C518302
- Background
A sulfone active against a wide range of bacteria but mainly employed for its actions against mycobacterium leprae. Its mechanism of action is probably similar to that of the sulfonamides which involves inhibition of folic acid synthesis in susceptible organisms. It is also used with pyrimethamine in the treatment of malaria. (From Martindale, The Extra Pharmacopoeia, 30th ed, p157-8)
- Indication
For the treatment and management of leprosy and dermatitis herpetiformis.
- Associated Conditions
- Acne Vulgaris, Bullous Systemic Lupus Erythematosus, Bullous dermatitis herpetiformis, Hansen's Disease, Pemphigus Vulgaris (PV), Relapsing Polychondritis, Mild Pneumocystis pneumonia, Mild Toxoplasma gondii encephalitis, Moderate Pneumocystis pneumonia, Moderate Toxoplasma gondii encephalitis, Refractory Idiopathic thrombocytopenic purpura
Phase IV Study to Gather More Information About the Safety of ACZONE Gel, 5% in Treating Subjects With Acne Who Have G6PD Deficiency
- Conditions
- Acne Vulgaris
- First Posted Date
- 2005-10-24
- Last Posted Date
- 2011-05-30
- Lead Sponsor
- Allergan
- Target Recruit Count
- 64
- Registration Number
- NCT00243542
- Locations
- 🇺🇸
Okatie Research Center, LLC, Beaufort, South Carolina, United States
🇺🇸Dermatology Associates, PC at the Washington Hospital Center, Washington, District of Columbia, United States
🇺🇸Dermatology Associates of Knoxville, Knoxville, Tennessee, United States
Metabolic Capacity of Israeli Populations
- Conditions
- Healthy Volunteers
- Interventions
- First Posted Date
- 2005-09-13
- Last Posted Date
- 2018-06-12
- Lead Sponsor
- Hadassah Medical Organization
- Target Recruit Count
- 1200
- Registration Number
- NCT00162383
- Locations
- 🇮🇱
Hadassah Medical Organization, Jerusalem, Israel
A Phase 3 Study to Compare the Safety and Efficacy of 5% Dapsone Topical Gel, (DTG) Twice Daily in Combination With Once Daily Vehicle Control, Adapalene Gel 0.1% or Benzoyl Peroxide Gel 4%
- Conditions
- Acne Vulgaris
- First Posted Date
- 2005-09-09
- Last Posted Date
- 2011-05-30
- Lead Sponsor
- Allergan
- Target Recruit Count
- 301
- Registration Number
- NCT00151541
Randomized Phase I Study of Trimetrexate Glucuronate (TMTX) With Leucovorin (LCV) Protection Plus Dapsone Versus Trimethoprim / Sulfamethoxazole (TMP/SMX) for Treatment of Moderately Severe Episodes of Pneumocystis Carinii Pneumonia
- Conditions
- HIV InfectionsPneumonia, Pneumocystis Carinii
- First Posted Date
- 2001-08-31
- Last Posted Date
- 2005-06-24
- Lead Sponsor
- U.S. Bioscience
- Target Recruit Count
- 20
- Registration Number
- NCT00002120
- Locations
- 🇺🇸
Los Angeles County / Health Research Assoc / Drew Med Ctr, Los Angeles, California, United States
Effect of Fluconazole, Clarithromycin, and Rifabutin on the Pharmacokinetics of Sulfamethoxazole-Trimethoprim and Dapsone and Their Hydroxylamine Metabolites
- Conditions
- Bacterial InfectionsMycosesHIV Infections
- First Posted Date
- 2001-08-31
- Last Posted Date
- 2021-10-29
- Target Recruit Count
- 48
- Registration Number
- NCT00000826
- Locations
- 🇺🇸
University of Washington AIDS CRS, Seattle, Washington, United States
🇺🇸Ucsf Aids Crs, San Francisco, California, United States
A Study of Three Drugs Plus Zidovudine in the Prevention of Infections in HIV-Infected Patients
- Conditions
- HIV InfectionsPneumonia, Pneumocystis Carinii
- First Posted Date
- 2001-08-31
- Last Posted Date
- 2021-11-04
- Target Recruit Count
- 600
- Registration Number
- NCT00000991
- Locations
- 🇺🇸
Chicago Children's CRS, Chicago, Illinois, United States
🇺🇸Johns Hopkins Adult AIDS CRS, Baltimore, Maryland, United States
🇺🇸Case CRS, Cleveland, Ohio, United States
Comparison of Two Dosage Regimens of Oral Dapsone for Prophylaxis of Pneumocystis Carinii Pneumonia in Pediatric HIV Infection
- Conditions
- Pneumonia, Pneumocystis CariniiHIV Infections
- First Posted Date
- 2001-08-31
- Last Posted Date
- 2021-11-04
- Target Recruit Count
- 96
- Registration Number
- NCT00000739
- Locations
- 🇺🇸
Usc La Nichd Crs, Los Angeles, California, United States
🇺🇸Univ. of Chicago - Dept. of Peds., Div. of Infectious Disease, Chicago, Illinois, United States
🇺🇸Emory Univ. School of Medicine, Dept. of Peds., Div. of Infectious Diseases, Atlanta, Georgia, United States
Dapsone 100 Mg Versus 50 as Primary Prophylaxis for Pneumocystis Carinii Pneumonia (PCP) in Patients With AIDS-Related Complex (ARC)
- Conditions
- Pneumonia, Pneumocystis CariniiHIV Infections
- First Posted Date
- 2001-08-31
- Last Posted Date
- 2005-06-24
- Lead Sponsor
- Jacobus Pharmaceutical
- Registration Number
- NCT00002043
- Locations
- 🇺🇸
UCLA CARE Ctr, Los Angeles, California, United States
A Comparison of Dapsone and Trimethoprim-Sulfamethoxazole in the Treatment of Pneumocystis Carinii Pneumonia (PCP) in Patients With AIDS
- Conditions
- Pneumonia, Pneumocystis CariniiHIV Infections
- First Posted Date
- 2001-08-31
- Last Posted Date
- 2005-06-24
- Lead Sponsor
- Jacobus Pharmaceutical
- Registration Number
- NCT00002283
- Locations
- 🇺🇸
Jacobus Pharmaceutical Co, Princeton, New Jersey, United States
A Phase III Comparative Study of Dapsone / Trimethoprim and Clindamycin / Primaquine Versus Sulfamethoxazole / Trimethoprim in the Treatment of Mild-to-Moderate PCP in Patients With AIDS
- Conditions
- HIV InfectionsPneumonia, Pneumocystis Carinii
- First Posted Date
- 2001-08-31
- Last Posted Date
- 2021-11-03
- Target Recruit Count
- 290
- Registration Number
- NCT00000640
- Locations
- 🇺🇸
Johns Hopkins Adult AIDS CRS, Baltimore, Maryland, United States
🇺🇸Methodist Hosp. of Indiana, Indianapolis, Indiana, United States
🇺🇸Massachusetts General Hospital ACTG CRS, Boston, Massachusetts, United States
Drug Development Updates
Stay informed with timely notifications on clinical trials, regulatory changes, and research advancements related to this medication.