Adefovir dipivoxil
- Generic Name
- Adefovir dipivoxil
- Brand Names
- Hepsera
- Drug Type
- Small Molecule
- Chemical Formula
- C20H32N5O8P
- CAS Number
- 142340-99-6
- Unique Ingredient Identifier
- U6Q8Z01514
- Background
Adefovir dipivoxil, previously called bis-POM PMEA, with trade names Preveon and Hepsera, is an orally-administered acyclic nucleotide analog reverse transcriptase inhibitor (ntRTI) used for treatment of hepatitis B. It is ineffective against HIV-1. Adefovir dipivoxil is the diester prodrug of adefovir.
- Indication
Indicated for the treatment of chronic hepatitis B in adult patients with evidence of active viral replication and either evidence of persistent elevations in serum aminotransferases (ALT or AST) or histologically active disease; this is based on histological, virological, biochemical, and serological responses in adult patients with HBeAg+ and HBeAg- chroni...
- Associated Conditions
- Chronic Hepatitis B Infection
- Associated Therapies
- -
EFFORT Further Extension Study
- Conditions
- Interventions
- First Posted Date
- 2016-07-07
- Last Posted Date
- 2016-07-07
- Lead Sponsor
- Nanfang Hospital, Southern Medical University
- Target Recruit Count
- 130
- Registration Number
- NCT02826070
- Locations
- 🇨🇳
Beijing Ditan Hospital, Beijing, Beijing, China
🇨🇳People's Hospital of Beijing University, Beijing, Beijing, China
🇨🇳The Third Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, China
A Study to Evaluate Efficacy and Safety of Peginterferon Alfa-2a (Pegasys) and Adeforvir Dipivoxil (ADV) in Participants With Lamivudine-Resistant Hepatitis B e Antigen (HBeAg)-Positive Chronic Hepatitis B
- Conditions
- Interventions
- First Posted Date
- 2015-11-05
- Last Posted Date
- 2016-02-02
- Lead Sponsor
- Hoffmann-La Roche
- Target Recruit Count
- 255
- Registration Number
- NCT02598063
Study of Effects and Safety Between Adefovir Dipivoxil Plus Polyene Phosphatidylcholine Versus Adefovir Dipivoxil Alone in Chronic Hepatitis B Patients
- Conditions
- Interventions
- First Posted Date
- 2011-09-19
- Last Posted Date
- 2011-09-19
- Lead Sponsor
- Jun Cheng
- Target Recruit Count
- 300
- Registration Number
- NCT01436539
- Locations
- 🇨🇳
Beijing Ditan Hospital, Capital Medical University, Beijing, China
Lamivudine and Adefovir Dipivoxil Fixed Dose Combination
- Conditions
- Interventions
- First Posted Date
- 2011-05-16
- Last Posted Date
- 2017-08-04
- Lead Sponsor
- GlaxoSmithKline
- Target Recruit Count
- 40
- Registration Number
- NCT01353742
- Locations
- 🇭🇰
GSK Investigational Site, Shatin, New Territories, Hong Kong
HEPSERA Post Marketing Surveillance
- First Posted Date
- 2011-04-05
- Last Posted Date
- 2017-07-05
- Lead Sponsor
- GlaxoSmithKline
- Target Recruit Count
- 4393
- Registration Number
- NCT01329419
A Phase II Study to Determine the Safety and Efficacy of Interferon-gamma in Patients With Chronic Hepatitis B
- Conditions
- Interventions
- First Posted Date
- 2008-09-16
- Last Posted Date
- 2010-10-21
- Lead Sponsor
- Huntington Medical Research Institutes
- Target Recruit Count
- 30
- Registration Number
- NCT00753467
- Locations
- 🇺🇸
Huntington Medical Research Institutes, Pasadena, California, United States
A Pilot Study to Evaluate the Safety and Efficacy of Clevudine or Adefovir Patients With LC-B
- First Posted Date
- 2008-05-06
- Last Posted Date
- 2014-12-18
- Lead Sponsor
- Bukwang Pharmaceutical
- Target Recruit Count
- 102
- Registration Number
- NCT00672867
- Locations
- 🇰🇷
Samsung Medical Center, Seoul, Korea, Republic of
ADVANCE Study: A Study of PEGASYS (Peginterferon Alfa-2a (40KD)) + Adefovir Dipivoxil in Patients With Hbe(-) Chronic Hepatitis B
- Conditions
- Interventions
- First Posted Date
- 2008-04-18
- Last Posted Date
- 2016-11-02
- Lead Sponsor
- Hoffmann-La Roche
- Target Recruit Count
- 10
- Registration Number
- NCT00661076
PK Study of Tacrolimus and Cyclosporine When Co-Administered With Adefovir Dipivoxil in Post-Liver Transplant Patients
- First Posted Date
- 2008-03-27
- Last Posted Date
- 2008-04-10
- Lead Sponsor
- Gilead Sciences
- Target Recruit Count
- 16
- Registration Number
- NCT00644761
- Locations
- 🇺🇸
University of Miami, Miami, Florida, United States
🇺🇸University of California, San Francisco, San Francisco, California, United States
🇺🇸University of Pittsburgh, Pittsburgh, Pennsylvania, United States
Open Label Study of Pharmacokinetics and Safety of Dose of Adefovir Dipivoxil in Children and Adolescents With HBV
- First Posted Date
- 2008-03-27
- Last Posted Date
- 2008-03-27
- Lead Sponsor
- Gilead Sciences
- Target Recruit Count
- 47
- Registration Number
- NCT00645294
- Locations
- 🇬🇧
King's College Hospital, London, England, United Kingdom
🇩🇪Standort Lindwurmstrasse, Munchen, Germany
🇵🇱Klinika Gastroenterologii, Warszawa, Poland
Drug Development Updates
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