A semisynthetic derivative of podophyllotoxin that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent entry into the mitotic phase of cell division, and lead to cell death. Etoposide acts primarily in the G2 and S phases of the cell cycle.
For use in combination with other chemotherapeutic agents in the treatment of refractory testicular tumors and as first line treatment in patients with small cell lung cancer. Also used to treat other malignancies such as lymphoma, non-lymphocytic leukemia, and glioblastoma multiforme.
McDowell Cancer Center at Akron General Medical Center, Akron, Ohio, United States
Charles M. Barrett Cancer Center at University Hospital, Cincinnati, Ohio, United States
Cleveland Clinic Taussig Cancer Center, Cleveland, Ohio, United States
Children's Healthcare of Atlanta - Arthur M Blank Hospital, Atlanta, Georgia, United States
Children's Hospital of Alabama, Birmingham, Alabama, United States
University of Alabama at Birmingham Cancer Center, Birmingham, Alabama, United States
University Hospital Motol, Prague, Czechia
CHR Hotel Dieu, Nantes, France
Children's Hospital and Regional Medical Center - Seattle, Seattle, Washington, United States
UW Health Oncology - 1 South Park, Madison, Wisconsin, United States
University of Wisconsin Hospital and Clinics, Madison, Wisconsin, United States
Sanford Cancer Center-Oncology Clinic, Sioux Falls, South Dakota, United States
City of Hope, Duarte, California, United States
UT MD Anderson Cancer Center, Houston, Texas, United States
Pennsylvania State University, Hershey, Pennsylvania, United States
Ireland Cancer Center, Case Western Reserve University, Division of Hematology/Oncology, Cleveland, Ohio, United States
University of Texas Southwestern Medical Center, Dallas, Texas, United States
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