A semisynthetic derivative of podophyllotoxin that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent entry into the mitotic phase of cell division, and lead to ce...
For use in combination with other chemotherapeutic agents in the treatment of refractory testicular tumors and as first line treatment in patients with small cell lung cancer. Also used to treat other malignancies such as lymphoma, non-lymphocytic leukemia, and glioblastoma multiforme.
The Children's Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, China
Chengdu Third People's Hospital, Chendu, Sichuan, China
People's Hospital of Deyang City, Deyang, Deyang, China
West China Hospital, Sichuan University, Chendu, Sichuan, China
Fred Hutch/University of Washington Cancer Consortium, Seattle, Washington, United States
Zhongda Hospital, Nanjing, Jiangsu, China
National Institutes of Health Clinical Center, Bethesda, Maryland, United States
Hospital General Universitario de Valencia, Valencia, Spain
ICO Badalona, Hospital Germans Trias i Pujol, Badalona, Barcelona, Spain
Hospitalario Universitario A Coruña, A Coruña, La Coruña, Spain
CHU de MONTPELLIER - Hôpital Arnaud de Villeneuve, Montpellier, France
Centre Léon Bérard, Lyon, France
CHRU NANCY - Hôpital d'Enfants, Vandœuvre-lès-Nancy, France
The First Affiliated Hospital of Medical College of Zhejiang University, Hangzhou, Zhejiang, China
Chao Family Comprehensive Cancer Center UCI, Orange, California, United States
Memorial Cancer Institute at Memorial West, Pembroke Pines, Florida, United States
The University of Chicago, Chicago, Illinois, United States
University of Southern California, Norris Comprehensive Cancer Center, Los Angeles, California, United States
Christiana Care Health Services, Newark, Delaware, United States
Henry Ford Health System, Detroit, Michigan, United States
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