Minocycline
- Generic Name
- Minocycline
- Brand Names
- Amzeeq, Arestin, Dynacin, Minocin, Minolira, Solodyn, Ximino, Zilxi
- Drug Type
- Small Molecule
- Chemical Formula
- C23H27N3O7
- CAS Number
- 10118-90-8
- Unique Ingredient Identifier
- FYY3R43WGO
- Background
Minocycline was first described in the literacture in 1966. It is a second generation tetracycline antibiotic that is active against gram-negative and gram-positive bacteria. Like other semisynthetic tetracyclines, minocycline has modifications to carbons 7-9 on the D ring to generate higher efficacy than previous tetracyclines.
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- Indication
Oral and topical minocycline are indicated to treat inflammatory lesions of acne vulgaris. Subgingival microspheres are indicated as an adjunct treatment in the reduction of pocket depth in adults with periodontitis. Oral and intravenous formulations are indicated to treat infections of susceptible microorganisms. These include rickettsiae, Mycoplasma pneumo...
- Associated Conditions
- Bartonellosis, Brucellosis, Campylobacter fetus, Chancroid, Cholera (Disorder), Conjunctivitis, Inclusion, Granuloma Inguinale, Lymphogranuloma Venereum, Nongonococcal urethritis, Periodontitis, Plague, Psittacosis, Q Fever, Relapsing Fever, Respiratory Tract Infections (RTI), Rickettsia Infections, Rickettsialpox, Rocky Mountain Spotted Fever, Trachoma, Tularemia, Typhus infections, Inflammatory lesions
- Associated Therapies
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A Pilot Study of Minocycline in Intracerebral Hemorrhage Patients
- First Posted Date
- 2013-03-06
- Last Posted Date
- 2018-04-26
- Lead Sponsor
- Augusta University
- Target Recruit Count
- 16
- Registration Number
- NCT01805895
- Locations
- 🇺🇸
Georgia Health Sciences University, Augusta, Georgia, United States
Kidney and Periodontal Disease Study
- Conditions
- Interventions
- First Posted Date
- 2013-03-01
- Last Posted Date
- 2019-04-30
- Lead Sponsor
- University of California, San Francisco
- Target Recruit Count
- 51
- Registration Number
- NCT01802216
Intervention for Symptom Burden During Maintenance Therapy for Multiple Myeloma
- Conditions
- Interventions
- First Posted Date
- 2013-02-15
- Last Posted Date
- 2021-11-24
- Lead Sponsor
- M.D. Anderson Cancer Center
- Target Recruit Count
- 88
- Registration Number
- NCT01793051
- Locations
- 🇺🇸
University of Texas MD Anderson Cancer Center, Houston, Texas, United States
A Phase II Study of Minocycline and Armodafinil for Reducing the Symptom Burden Produced by Chemoradiation Treatment for Esophageal Cancer
- Conditions
- Interventions
- First Posted Date
- 2012-12-10
- Last Posted Date
- 2018-06-06
- Lead Sponsor
- M.D. Anderson Cancer Center
- Target Recruit Count
- 22
- Registration Number
- NCT01746043
- Locations
- 🇺🇸
University of Texas MD Anderson Cancer Center, Houston, Texas, United States
Novel Medication Strategies Targeting Brain Mechanisms in Pediatric OCD
- First Posted Date
- 2012-09-27
- Last Posted Date
- 2019-11-13
- Lead Sponsor
- New York State Psychiatric Institute
- Target Recruit Count
- 31
- Registration Number
- NCT01695291
- Locations
- 🇺🇸
Weill Cornell Medical Center, New York, New York, United States
🇺🇸New York State Psychiatric Institute, New York, New York, United States
Minocycline Study in Pancreatic Cancer Patients
- Conditions
- Interventions
- First Posted Date
- 2012-09-26
- Last Posted Date
- 2020-03-09
- Lead Sponsor
- M.D. Anderson Cancer Center
- Target Recruit Count
- 80
- Registration Number
- NCT01693523
- Locations
- 🇺🇸
University of Texas MD Anderson Cancer Center, Houston, Texas, United States
Open Treatment of Minocycline in Geriatric Depression
- First Posted Date
- 2012-08-07
- Last Posted Date
- 2017-05-12
- Lead Sponsor
- Weill Medical College of Cornell University
- Target Recruit Count
- 16
- Registration Number
- NCT01659320
- Locations
- 🇺🇸
Institute of Geriatric Psychiatry, White Plains, New York, United States
Minocycline Study in Non Small Cell Lung Cancer (NSCLC) Patients for Chemoradiation Therapy
- Conditions
- Interventions
- First Posted Date
- 2012-07-10
- Last Posted Date
- 2020-07-17
- Lead Sponsor
- M.D. Anderson Cancer Center
- Target Recruit Count
- 51
- Registration Number
- NCT01636934
- Locations
- 🇺🇸
University of Texas MD Anderson Cancer Center, Houston, Texas, United States
Repeat Radiation, Minocycline and Bevacizumab in Patients With Recurrent Glioma
- Conditions
- Interventions
- First Posted Date
- 2012-04-19
- Last Posted Date
- 2019-08-16
- Lead Sponsor
- University of Utah
- Target Recruit Count
- 22
- Registration Number
- NCT01580969
- Locations
- 🇺🇸
Huntsman Cancer Institute, Salt Lake City, Utah, United States
Open Study Assessing the Feasibility of Minocycline in Patients With Unipolar Depression
- First Posted Date
- 2012-04-10
- Last Posted Date
- 2012-07-04
- Lead Sponsor
- Shalvata Mental Health Center
- Target Recruit Count
- 30
- Registration Number
- NCT01574742
- Locations
- 🇮🇱
Shalvata Medical Health Center, Hod-HaSharon, Israel
Drug Development Updates
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