Minocycline
- Generic Name
- Minocycline
- Brand Names
- Amzeeq, Arestin, Dynacin, Minocin, Minolira, Solodyn, Ximino, Zilxi
- Drug Type
- Small Molecule
- Chemical Formula
- C23H27N3O7
- CAS Number
- 10118-90-8
- Unique Ingredient Identifier
- FYY3R43WGO
- Background
Minocycline was first described in the literacture in 1966. It is a second generation tetracycline antibiotic that is active against gram-negative and gram-positive bacteria. Like other semisynthetic tetracyclines, minocycline has modifications to carbons 7-9 on the D ring to generate higher efficacy than previous tetracyclines.
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- Indication
Oral and topical minocycline are indicated to treat inflammatory lesions of acne vulgaris. Subgingival microspheres are indicated as an adjunct treatment in the reduction of pocket depth in adults with periodontitis. Oral and intravenous formulations are indicated to treat infections of susceptible microorganisms. These include rickettsiae, Mycoplasma pneumo...
- Associated Conditions
- Bartonellosis, Brucellosis, Campylobacter fetus, Chancroid, Cholera (Disorder), Conjunctivitis, Inclusion, Granuloma Inguinale, Lymphogranuloma Venereum, Nongonococcal urethritis, Periodontitis, Plague, Psittacosis, Q Fever, Relapsing Fever, Respiratory Tract Infections (RTI), Rickettsia Infections, Rickettsialpox, Rocky Mountain Spotted Fever, Trachoma, Tularemia, Typhus infections, Inflammatory lesions
- Associated Therapies
- -
Study to Evaluate the Efficacy and Safety of Minocycline in Angelman Syndrome
- Conditions
- Interventions
- First Posted Date
- 2014-02-06
- Last Posted Date
- 2015-10-21
- Lead Sponsor
- Puerta de Hierro University Hospital
- Target Recruit Count
- 32
- Registration Number
- NCT02056665
- Locations
- 🇪🇸
Puerta de Hierro University Hospital, Madrid, Spain
Minocycline for Postsurgical Symptom Reduction in Head and Neck Cancer
- Conditions
- Interventions
- First Posted Date
- 2014-02-05
- Last Posted Date
- 2022-10-20
- Lead Sponsor
- M.D. Anderson Cancer Center
- Target Recruit Count
- 30
- Registration Number
- NCT02055963
- Locations
- 🇺🇸
University of Texas MD Anderson Cancer Center, Houston, Texas, United States
Minocycline to Reduce Pain After Carpal Tunnel Release
- Conditions
- Interventions
- First Posted Date
- 2014-01-31
- Last Posted Date
- 2018-06-11
- Lead Sponsor
- VA Palo Alto Health Care System
- Target Recruit Count
- 131
- Registration Number
- NCT02051296
- Locations
- 🇺🇸
Palo Alto VA, Palo Alto, California, United States
Minocycline Bioequivalence Study
- First Posted Date
- 2013-09-10
- Last Posted Date
- 2013-11-18
- Lead Sponsor
- GlaxoSmithKline
- Target Recruit Count
- 28
- Registration Number
- NCT01938508
- Locations
- 🇲🇽
GSK Investigational Site, Mexico City, Mexico
Phase II Study of Minocycline for Reducing Symptom Burden in Colorectal Patients
- Conditions
- Interventions
- First Posted Date
- 2013-07-23
- Last Posted Date
- 2020-03-17
- Lead Sponsor
- M.D. Anderson Cancer Center
- Target Recruit Count
- 122
- Registration Number
- NCT01906008
- Locations
- 🇺🇸
LBJ Hospital, Houston, Texas, United States
🇺🇸University of Texas MD Anderson Cancer Center, Houston, Texas, United States
Effect of Minocycline on Pain Caused by Nerve Damage
- Conditions
- Interventions
- First Posted Date
- 2013-06-05
- Last Posted Date
- 2015-01-27
- Lead Sponsor
- Ziekenhuis Oost-Limburg
- Target Recruit Count
- 60
- Registration Number
- NCT01869907
- Locations
- 🇧🇪
Ziekenhuis Oost-Limburg, Genk, Limburg, Belgium
Minocycline in Acute Spinal Cord Injury (MASC)
- First Posted Date
- 2013-04-10
- Last Posted Date
- 2014-10-30
- Lead Sponsor
- Rick Hansen Institute
- Target Recruit Count
- 248
- Registration Number
- NCT01828203
- Locations
- 🇦🇺
Princess Alexandra Hospital, Brisbane, Queensland, Australia
🇨🇦University of Alberta & Royal Alexandra Hospitals, Edmonton, Alberta, Canada
🇨🇦Foothills Medical Centre, Calgary, Alberta, Canada
Prevention of Imminent Paralysis Following Spinal Cord Trauma or Ischemia by Minocycline: A Multi-center Study in Israel With IDF Primary Care Involvement
- Conditions
- Interventions
- First Posted Date
- 2013-03-18
- Last Posted Date
- 2013-03-18
- Lead Sponsor
- Hadassah Medical Organization
- Target Recruit Count
- 444
- Registration Number
- NCT01813240
- Locations
- 🇮🇱
Hadassah Medical Organization, Jerusalem, Israel
The Effect of Minocycline on Relapse After Successful Intravenous Ketamine/Minocycline-induced Symptoms Response in Subjects With Depression
- Conditions
- Interventions
- First Posted Date
- 2013-03-12
- Last Posted Date
- 2015-06-30
- Lead Sponsor
- Janssen Research & Development, LLC
- Target Recruit Count
- 29
- Registration Number
- NCT01809340
Minocycline for Schizophrenia
- First Posted Date
- 2013-03-12
- Last Posted Date
- 2016-06-30
- Lead Sponsor
- Addis Ababa University
- Target Recruit Count
- 150
- Registration Number
- NCT01809158
- Locations
- 🇪🇹
Amanuel Psychiatric Hospital, Addis Ababa, Ethiopia
Drug Development Updates
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