Xevinapant
- Generic Name
- Xevinapant
- Drug Type
- Small Molecule
- Chemical Formula
- C32H43N5O4
- CAS Number
- 1071992-99-8
- Unique Ingredient Identifier
- N65WC8PXDD
Study to Assess Safety and Efficacy of the Second Mitochondrial-derived Activator of Caspases (SMAC) Mimetic Debio 1143
- First Posted Date
- 2019-10-10
- Last Posted Date
- 2023-06-12
- Lead Sponsor
- Debiopharm International SA
- Target Recruit Count
- 46
- Registration Number
- NCT04122625
- Locations
- 🇺🇸
Rush University Medical Center, Chicago, Illinois, United States
🇺🇸Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States
🇺🇸Dana-Farber/Partners Cancer Care, Boston, Massachusetts, United States
Pembrolizumab In Combination With Debio 1143 In Pancreatic and Colorectal Advanced/Metastatic Adenocarcinoma
- Conditions
- Adenocarcinoma of the PancreasAdenocarcinoma of the ColonAdenocarcinoma of the Rectum
- Interventions
- First Posted Date
- 2019-03-12
- Last Posted Date
- 2023-02-17
- Lead Sponsor
- Centre Leon Berard
- Target Recruit Count
- 54
- Registration Number
- NCT03871959
- Locations
- 🇫🇷
Centre Léon Bérard, Lyon, France
A Dose-Finding Study of the Second Mitochondrial Activator of Caspases (SMAC) Mimetic Debio 1143 When Given in Combination With Avelumab to Participants With Advanced Solid Malignancies and to Participants With Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC) After Platinum-Based Therapy
- Conditions
- Carcinoma, Non-Small-Cell LungNeoplasms
- Interventions
- First Posted Date
- 2017-09-01
- Last Posted Date
- 2022-06-01
- Lead Sponsor
- Debiopharm International SA
- Target Recruit Count
- 54
- Registration Number
- NCT03270176
- Locations
- 🇨🇦
British Columbia Cancer Agency, Vancouver, British Columbia, Canada
🇷🇴Institutul Oncologic "Prof. Dr. Ion Chiricuţă" Cluj Napoca, Cluj-Napoca, Romania
🇷🇴Centrul de Oncologie, S.C. Centrul de Oncologie Sf. Nectarie S.R.L, Oncologie Medicala, Craiova, Romania
Debio 1143-201 Dose-finding and Efficacy Phase I/II Trial
- Conditions
- Squamous Cell Carcinoma of the Head and Neck
- Interventions
- First Posted Date
- 2013-12-27
- Last Posted Date
- 2022-06-23
- Lead Sponsor
- Debiopharm International SA
- Target Recruit Count
- 144
- Registration Number
- NCT02022098
- Locations
- 🇫🇷
C.H.U. Sud Amiens, Amiens, France
🇫🇷Centre Jean Perrin, Clermont-Ferrand Cedex 01, France
🇫🇷Centre Hospitalier de Bretagne Sud - HÔPITAL DU SCORFF, Lorient, Bp 2233, France
Drug Development Updates
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